(108 nodes) Mixed, incl. Protein-protein interactions at synapses, and Apical junction complex network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GRIP1	Glutamate receptor interacting protein 1. (938 aa)
	LOC102354725	Glutamate receptor, ionotropic, AMPA 3a. (823 aa)
	GRIA2	Glutamate ionotropic receptor AMPA type subunit 2; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (242 aa)
	SLC16A12	Solute carrier family 16 member 12. (303 aa)
	LOC102347948	Uncharacterized protein. (290 aa)
	PATJ	PATJ crumbs cell polarity complex component. (2073 aa)
	CGN	Cingulin. (1381 aa)
	FAM78B	Family with sequence similarity 78 member B. (183 aa)
	LRFN2	Leucine rich repeat and fibronectin type III domain containing 2. (762 aa)
	GRIN2A	Glutamate ionotropic receptor NMDA type subunit 2A; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1088 aa)
	DLGAP2	DLG associated protein 2. (1003 aa)
	CFTR	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1491 aa)
	USP46	Ubiquitin specific peptidase 46; Belongs to the peptidase C19 family. (366 aa)
	LOC102356557	Neurexin 3a. (835 aa)
	SHANK1	SH3 and multiple ankyrin repeat domains 1. (1849 aa)
	APCDD1	APC down-regulated 1. (516 aa)
	PARD3B	Uncharacterized protein. (1094 aa)
	CARD10	Caspase recruitment domain family member 10. (1063 aa)
	H3A3Q1_LATCH	Uncharacterized protein. (252 aa)
	CNIH4	Cornichon family AMPA receptor auxiliary protein 4. (131 aa)
	NLGN1	Neuroligin 1. (635 aa)
	GRIP2	Glutamate receptor interacting protein 2. (1064 aa)
	SHANK3	SH3 and multiple ankyrin repeat domains 3. (1187 aa)
	LOC102349972	Uncharacterized protein. (246 aa)
	SHANK2	SH3 and multiple ankyrin repeat domains 2. (1161 aa)
	MDGA2	MAM domain-containing protein. (288 aa)
	MDGA1	MAM domain containing glycosylphosphatidylinositol anchor 1. (518 aa)
	LLGL1	LLGL scribble cell polarity complex component 1. (997 aa)
	LOC102355148	Si:cabz01090165.1. (617 aa)
	LOC102354107	Neuroligin 4 X-linked a. (835 aa)
	EZR	Ezrin. (591 aa)
	CACNG8	Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (367 aa)
	LOC102360693	FERM domain-containing protein. (560 aa)
	JAM2	Junctional adhesion molecule 2. (292 aa)
	DLGAP1	DLG associated protein 1. (999 aa)
	MPP7	Membrane palmitoylated protein 7; Belongs to the MAGUK family. (576 aa)
	PICK1	Protein interacting with PRKCA 1. (409 aa)
	H3ACT9_LATCH	PDZ domain-containing protein. (264 aa)
	GOPC	Golgi-associated PDZ and coiled-coil motif containing. (456 aa)
	LOC102363797	Uncharacterized protein. (603 aa)
	H3AG75_LATCH	Uncharacterized protein. (90 aa)
	H3AGA4_LATCH	Uncharacterized protein. (409 aa)
	PACS2	Phosphofurin acidic cluster sorting protein 2. (853 aa)
	H3AHQ4_LATCH	PB1 domain-containing protein. (116 aa)
	GRIN2B	Glutamate ionotropic receptor NMDA type subunit 2B. (1450 aa)
	H3AI01_LATCH	Uncharacterized protein. (436 aa)
	GRIA4	Glutamate ionotropic receptor AMPA type subunit 4. (903 aa)
	PARD6B	Par-6 family cell polarity regulator beta. (369 aa)
	MPDZ	Multiple PDZ domain crumbs cell polarity complex component. (1679 aa)
	APCDD1L	APC down-regulated 1 like. (497 aa)
	H3AM13_LATCH	COesterase domain-containing protein. (139 aa)
	H3AMQ8_LATCH	Uncharacterized protein. (228 aa)
	NLGN2	Neuroligin 2. (802 aa)
	MPP5	Membrane palmitoylated protein 5; Belongs to the MAGUK family. (678 aa)
	LLGL2	LLGL scribble cell polarity complex component 2. (1030 aa)
	H3AP17_LATCH	MAM domain containing glycosylphosphatidylinositol anchor 2a. (531 aa)
	MAP4K3	Mitogen-activated protein kinase kinase kinase kinase 3; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (869 aa)
	NLGN3	Neuroligin 3. (855 aa)
	H3ARN6_LATCH	Uncharacterized protein. (239 aa)
	SLC16A14	Solute carrier family 16 member 14. (549 aa)
	GRIN3A	Glutamate ionotropic receptor NMDA type subunit 3A. (1109 aa)
	TJP2	Tight junction protein 2a (zona occludens 2). (1241 aa)
	EPB41L3	Erythrocyte membrane protein band 4.1 like 3. (1092 aa)
	LOC102364024	Ligand of numb-protein X 2b. (690 aa)
	DLG2	Guanylate kinase-like domain-containing protein. (215 aa)
	DLGAP3	DLG associated protein 3. (975 aa)
	GRIN2C	Glutamate ionotropic receptor NMDA type subunit 2C. (1375 aa)
	JAM3	Junctional adhesion molecule 3. (208 aa)
	MPP3	Membrane palmitoylated protein 3; Belongs to the MAGUK family. (586 aa)
	SERPINI1	Serpin family I member 1; Belongs to the serpin family. (409 aa)
	H3AXP8_LATCH	Uncharacterized protein. (86 aa)
	LRRTM2	Leucine rich repeat transmembrane neuronal 2. (522 aa)
	H3AYT1_LATCH	Uncharacterized protein. (238 aa)
	H3AYY9_LATCH	Uncharacterized protein. (127 aa)
	DLG4	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (828 aa)
	NRXN2	Uncharacterized protein. (740 aa)
	TJP3	Tight junction protein 3; Belongs to the MAGUK family. (859 aa)
	PARD6A	Par-6 family cell polarity regulator alpha. (307 aa)
	GRIN2D	Glutamate ionotropic receptor NMDA type subunit 2D. (1276 aa)
	AATK	Apoptosis associated tyrosine kinase. (1576 aa)
	PRKCZ	Protein kinase C; Belongs to the protein kinase superfamily. (479 aa)
	SLC9A3R1	SLC9A3 regulator 1. (389 aa)
	LOC102354703	Nicotinamide nucleotide transhydrogenase 2. (1089 aa)
	DLGAP4	DLG associated protein 4. (951 aa)
	PRKCI	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (589 aa)
	TSPAN7	Tetraspanin. (254 aa)
	PARD3	Par-3 family cell polarity regulator. (1214 aa)
	MSN	Moesin. (583 aa)
	DLG1	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (928 aa)
	H3BB64_LATCH	Uncharacterized protein. (81 aa)
	CYTH1	Cytohesin 1. (321 aa)
	AK1	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. (211 aa)
	H3BBQ1_LATCH	Uncharacterized protein. (1715 aa)
	LOC102352021	LAM_G_DOMAIN domain-containing protein. (696 aa)
	H3BCA3_LATCH	Uncharacterized protein. (386 aa)
	H3BDY0_LATCH	PDZ domain-containing protein. (885 aa)
	PDZD3	PDZ domain containing 3. (459 aa)
	NAALADL1	N-acetylated alpha-linked acidic dipeptidase like 1. (742 aa)
	GRIA1	Glutamate ionotropic receptor AMPA type subunit 1. (835 aa)
	CRB2	Uncharacterized protein. (1473 aa)
	LOC102350038	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (597 aa)
	LOC102360602	Si:ch211-71n6.4. (572 aa)
	LOC102365550	Uncharacterized protein. (218 aa)
	EPB41L1	Erythrocyte membrane protein band 4.1 like 1. (795 aa)
	GRIN3B	Glutamate ionotropic receptor NMDA type subunit 3B. (907 aa)
	LOC102358289	Uncharacterized protein. (379 aa)
	DLG3	Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family. (901 aa)
	EPB41L2	Erythrocyte membrane protein band 4.1 like 2. (905 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AATK	CYTH1	ENSLACP00000016387	ENSLACP00000019136	Apoptosis associated tyrosine kinase.	Cytohesin 1.	0.671
AATK	GRIN2A	ENSLACP00000016387	ENSLACP00000002756	Apoptosis associated tyrosine kinase.	Glutamate ionotropic receptor NMDA type subunit 2A; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.	0.499
AATK	GRIN2C	ENSLACP00000016387	ENSLACP00000013360	Apoptosis associated tyrosine kinase.	Glutamate ionotropic receptor NMDA type subunit 2C.	0.668
AATK	GRIN2D	ENSLACP00000016387	ENSLACP00000016385	Apoptosis associated tyrosine kinase.	Glutamate ionotropic receptor NMDA type subunit 2D.	0.657
AK1	LOC102350038	ENSLACP00000019168	ENSLACP00000021606	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	0.701
AK1	PACS2	ENSLACP00000019168	ENSLACP00000008924	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.	Phosphofurin acidic cluster sorting protein 2.	0.654
CACNG8	CNIH4	ENSLACP00000006684	ENSLACP00000004300	Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	Cornichon family AMPA receptor auxiliary protein 4.	0.653
CACNG8	DLG1	ENSLACP00000006684	ENSLACP00000018954	Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family.	0.463
CACNG8	DLG2	ENSLACP00000006684	ENSLACP00000013231	Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	Guanylate kinase-like domain-containing protein.	0.455
CACNG8	DLG3	ENSLACP00000006684	ENSLACP00000022891	Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family.	0.463
CACNG8	DLG4	ENSLACP00000006684	ENSLACP00000015101	Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	0.463
CACNG8	GRIA1	ENSLACP00000006684	ENSLACP00000021016	Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	Glutamate ionotropic receptor AMPA type subunit 1.	0.965
CACNG8	GRIA2	ENSLACP00000006684	ENSLACP00000000770	Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	Glutamate ionotropic receptor AMPA type subunit 2; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.	0.955
CACNG8	GRIA4	ENSLACP00000006684	ENSLACP00000009506	Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	Glutamate ionotropic receptor AMPA type subunit 4.	0.814
CACNG8	H3BB64_LATCH	ENSLACP00000006684	ENSLACP00000019135	Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	Uncharacterized protein.	0.740
CACNG8	LOC102349972	ENSLACP00000006684	ENSLACP00000004967	Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	Uncharacterized protein.	0.463
CACNG8	LOC102354725	ENSLACP00000006684	ENSLACP00000000717	Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	Glutamate receptor, ionotropic, AMPA 3a.	0.809
CARD10	DLGAP1	ENSLACP00000004260	ENSLACP00000006811	Caspase recruitment domain family member 10.	DLG associated protein 1.	0.401
CARD10	DLGAP2	ENSLACP00000004260	ENSLACP00000003053	Caspase recruitment domain family member 10.	DLG associated protein 2.	0.401
CARD10	DLGAP3	ENSLACP00000004260	ENSLACP00000013348	Caspase recruitment domain family member 10.	DLG associated protein 3.	0.401