(5 nodes) Cellular ketone body metabolic process network (Latimeria chalumnae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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Predicted Interactions

gene neighborhood

gene fusions

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Your Input:
	ACAT1	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (422 aa)
	OXCT1	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. (530 aa)
	AUH	AU RNA binding methylglutaconyl-CoA hydratase. (282 aa)
	HMGCLL1	3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1. (262 aa)
	HMGCL	3-hydroxy-3-methylglutaryl-CoA lyase. (339 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACAT1	AUH	ENSLACP00000002727	ENSLACP00000008049	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	AU RNA binding methylglutaconyl-CoA hydratase.	0.706
ACAT1	HMGCL	ENSLACP00000002727	ENSLACP00000011773	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxy-3-methylglutaryl-CoA lyase.	0.950
ACAT1	HMGCLL1	ENSLACP00000002727	ENSLACP00000008800	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1.	0.950
ACAT1	OXCT1	ENSLACP00000002727	ENSLACP00000005497	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.	0.973
AUH	ACAT1	ENSLACP00000008049	ENSLACP00000002727	AU RNA binding methylglutaconyl-CoA hydratase.	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	0.706
AUH	HMGCL	ENSLACP00000008049	ENSLACP00000011773	AU RNA binding methylglutaconyl-CoA hydratase.	3-hydroxy-3-methylglutaryl-CoA lyase.	0.972
AUH	HMGCLL1	ENSLACP00000008049	ENSLACP00000008800	AU RNA binding methylglutaconyl-CoA hydratase.	3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1.	0.972
AUH	OXCT1	ENSLACP00000008049	ENSLACP00000005497	AU RNA binding methylglutaconyl-CoA hydratase.	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.	0.552
HMGCL	ACAT1	ENSLACP00000011773	ENSLACP00000002727	3-hydroxy-3-methylglutaryl-CoA lyase.	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	0.950
HMGCL	AUH	ENSLACP00000011773	ENSLACP00000008049	3-hydroxy-3-methylglutaryl-CoA lyase.	AU RNA binding methylglutaconyl-CoA hydratase.	0.972
HMGCL	HMGCLL1	ENSLACP00000011773	ENSLACP00000008800	3-hydroxy-3-methylglutaryl-CoA lyase.	3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1.	0.901
HMGCL	OXCT1	ENSLACP00000011773	ENSLACP00000005497	3-hydroxy-3-methylglutaryl-CoA lyase.	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.	0.963
HMGCLL1	ACAT1	ENSLACP00000008800	ENSLACP00000002727	3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1.	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	0.950
HMGCLL1	AUH	ENSLACP00000008800	ENSLACP00000008049	3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1.	AU RNA binding methylglutaconyl-CoA hydratase.	0.972
HMGCLL1	HMGCL	ENSLACP00000008800	ENSLACP00000011773	3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1.	3-hydroxy-3-methylglutaryl-CoA lyase.	0.901
HMGCLL1	OXCT1	ENSLACP00000008800	ENSLACP00000005497	3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1.	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.	0.963
OXCT1	ACAT1	ENSLACP00000005497	ENSLACP00000002727	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	0.973
OXCT1	AUH	ENSLACP00000005497	ENSLACP00000008049	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.	AU RNA binding methylglutaconyl-CoA hydratase.	0.552
OXCT1	HMGCL	ENSLACP00000005497	ENSLACP00000011773	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.	3-hydroxy-3-methylglutaryl-CoA lyase.	0.963
OXCT1	HMGCLL1	ENSLACP00000005497	ENSLACP00000008800	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.	3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1.	0.963