(12 nodes) Voltage-gated sodium channel complex network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	H2ZUL4_LATCH	Uncharacterized protein. (1374 aa)
	SCN10A	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1202 aa)
	SCN1B	Sodium voltage-gated channel beta subunit 1. (221 aa)
	SCN2A	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1702 aa)
	H3AG91_LATCH	Uncharacterized protein. (537 aa)
	SCN4A	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1836 aa)
	SCN3B	Sodium voltage-gated channel beta subunit 3. (216 aa)
	LOC102354872	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1673 aa)
	NAV1	AAA domain-containing protein. (1482 aa)
	SCN4B	Sodium voltage-gated channel beta subunit 4. (210 aa)
	SCN2B	Sodium voltage-gated channel beta subunit 2. (215 aa)
	SCN8A	Sodium voltage-gated channel alpha subunit 8. (1587 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
H2ZUL4_LATCH	LOC102354872	ENSLACP00000001085	ENSLACP00000014236	Uncharacterized protein.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.470
H2ZUL4_LATCH	SCN1B	ENSLACP00000001085	ENSLACP00000005402	Uncharacterized protein.	Sodium voltage-gated channel beta subunit 1.	0.874
H2ZUL4_LATCH	SCN2B	ENSLACP00000001085	ENSLACP00000021243	Uncharacterized protein.	Sodium voltage-gated channel beta subunit 2.	0.902
H2ZUL4_LATCH	SCN3B	ENSLACP00000001085	ENSLACP00000012591	Uncharacterized protein.	Sodium voltage-gated channel beta subunit 3.	0.637
H2ZUL4_LATCH	SCN4A	ENSLACP00000001085	ENSLACP00000010984	Uncharacterized protein.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.560
H2ZUL4_LATCH	SCN4B	ENSLACP00000001085	ENSLACP00000021221	Uncharacterized protein.	Sodium voltage-gated channel beta subunit 4.	0.641
H2ZUL4_LATCH	SCN8A	ENSLACP00000001085	ENSLACP00000021496	Uncharacterized protein.	Sodium voltage-gated channel alpha subunit 8.	0.423
H3AG91_LATCH	LOC102354872	ENSLACP00000008662	ENSLACP00000014236	Uncharacterized protein.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.893
H3AG91_LATCH	SCN1B	ENSLACP00000008662	ENSLACP00000005402	Uncharacterized protein.	Sodium voltage-gated channel beta subunit 1.	0.811
H3AG91_LATCH	SCN2B	ENSLACP00000008662	ENSLACP00000021243	Uncharacterized protein.	Sodium voltage-gated channel beta subunit 2.	0.853
H3AG91_LATCH	SCN3B	ENSLACP00000008662	ENSLACP00000012591	Uncharacterized protein.	Sodium voltage-gated channel beta subunit 3.	0.456
H3AG91_LATCH	SCN4B	ENSLACP00000008662	ENSLACP00000021221	Uncharacterized protein.	Sodium voltage-gated channel beta subunit 4.	0.641
LOC102354872	H2ZUL4_LATCH	ENSLACP00000014236	ENSLACP00000001085	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Uncharacterized protein.	0.470
LOC102354872	H3AG91_LATCH	ENSLACP00000014236	ENSLACP00000008662	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Uncharacterized protein.	0.893
LOC102354872	SCN10A	ENSLACP00000014236	ENSLACP00000003463	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.402
LOC102354872	SCN1B	ENSLACP00000014236	ENSLACP00000005402	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Sodium voltage-gated channel beta subunit 1.	0.526
LOC102354872	SCN2A	ENSLACP00000014236	ENSLACP00000008553	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.424
LOC102354872	SCN2B	ENSLACP00000014236	ENSLACP00000021243	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Sodium voltage-gated channel beta subunit 2.	0.641
LOC102354872	SCN3B	ENSLACP00000014236	ENSLACP00000012591	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Sodium voltage-gated channel beta subunit 3.	0.458
LOC102354872	SCN4A	ENSLACP00000014236	ENSLACP00000010984	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.424