STRINGSTRING
LOC102349382 LOC102349382 LOC102361952 LOC102361952 IDI1 IDI1 LIPA LIPA LOC102346260 LOC102346260 HSD3B7 HSD3B7 LOC102363673 LOC102363673 H2ZVK5_LATCH H2ZVK5_LATCH SQLE SQLE LOC102363644 LOC102363644 NSDHL NSDHL PMVK PMVK LOC102363544 LOC102363544 LOC102357417 LOC102357417 SDR42E1 SDR42E1 H3A1M4_LATCH H3A1M4_LATCH CH25H CH25H SULT2B1 SULT2B1 CYP51A1 CYP51A1 SIGMAR1 SIGMAR1 LOC102352197 LOC102352197 CYP7B1 CYP7B1 HSD17B2 HSD17B2 HSD11B2 HSD11B2 LOC102354799 LOC102354799 MVD MVD DHCR24 DHCR24 H3AD94_LATCH H3AD94_LATCH HMGCS1 HMGCS1 CYP39A1 CYP39A1 TM7SF2 TM7SF2 CYP7A1 CYP7A1 LOC102346667 LOC102346667 FDFT1 FDFT1 STS STS H3AHQ6_LATCH H3AHQ6_LATCH CYP4V2 CYP4V2 LOC102364638 LOC102364638 AKR1D1 AKR1D1 HMGCR HMGCR LOC102347924 LOC102347924 CYP19A1 CYP19A1 LOC102362530 LOC102362530 CYP2R1 CYP2R1 H3APN0_LATCH H3APN0_LATCH RUSC1 RUSC1 LSS LSS LOC102350971 LOC102350971 SOAT1 SOAT1 LOC102360223 LOC102360223 LOC102347380 LOC102347380 AACS AACS H3AT94_LATCH H3AT94_LATCH LOC102363496 LOC102363496 HSD17B7 HSD17B7 LOC102363771 LOC102363771 GGPS1 GGPS1 SRD5A3 SRD5A3 LOC102364039 LOC102364039 H3AZM3_LATCH H3AZM3_LATCH LOC102364287 LOC102364287 UGT1A1 UGT1A1 LOC102345423 LOC102345423 LOC102346130 LOC102346130 H3B0V4_LATCH H3B0V4_LATCH CYP20A1 CYP20A1 LOC102357693 LOC102357693 CYP24A1 CYP24A1 LOC102364376 LOC102364376 CYP27C1 CYP27C1 LOC102354597 LOC102354597 LOC102349366 LOC102349366 ACAT2 ACAT2 LOC102345588 LOC102345588 DHCR7 DHCR7 CYP46A1 CYP46A1 H3B8W8_LATCH H3B8W8_LATCH LOC102362765 LOC102362765 R3HDM4 R3HDM4 LOC102363927 LOC102363927 SOAT2 SOAT2 LOC102349421 LOC102349421 PTGIS PTGIS LOC102357152 LOC102357152 CYP27A1 CYP27A1 CCDC160 CCDC160 CYP27B1 CYP27B1 POR POR HSD11B1 HSD11B1 FAXDC2 FAXDC2 ERG28 ERG28 MVK MVK SRD5A1 SRD5A1 LOC102365730 LOC102365730 EAF2-2 EAF2-2 HSD17B3 HSD17B3 SC5D SC5D SRD5A2 SRD5A2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC102349382Methyltransf_11 domain-containing protein. (238 aa)
LOC102361952Uncharacterized protein; Belongs to the cytochrome P450 family. (212 aa)
IDI1Isopentenyl-diphosphate delta isomerase 1. (278 aa)
LIPALipase; Belongs to the AB hydrolase superfamily. Lipase family. (398 aa)
LOC102346260UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (534 aa)
HSD3B7Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7; Belongs to the 3-beta-HSD family. (377 aa)
LOC102363673Sulfotransferase; Belongs to the sulfotransferase 1 family. (247 aa)
H2ZVK5_LATCHCytochrome P450, family 17, subfamily A, polypeptide 2; Belongs to the cytochrome P450 family. (402 aa)
SQLESE domain-containing protein. (506 aa)
LOC102363644Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. (262 aa)
NSDHLNAD(P) dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family. (340 aa)
PMVKPhosphomevalonate kinase. (188 aa)
LOC102363544Uncharacterized protein. (1162 aa)
LOC102357417Uncharacterized protein; Belongs to the cytochrome P450 family. (512 aa)
SDR42E1Short chain dehydrogenase/reductase family 42E, member 1. (409 aa)
H3A1M4_LATCHUncharacterized protein. (457 aa)
CH25HCholesterol 25-hydroxylase; Belongs to the sterol desaturase family. (284 aa)
SULT2B1Sulfotransferase; Belongs to the sulfotransferase 1 family. (296 aa)
CYP51A1Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family. (508 aa)
SIGMAR1Sigma non-opioid intracellular receptor 1. (223 aa)
LOC102352197Methyltranfer_dom domain-containing protein. (272 aa)
CYP7B1Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (480 aa)
HSD17B2Hydroxysteroid 17-beta dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (298 aa)
HSD11B2Hydroxysteroid (11-beta) dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (303 aa)
LOC102354799Uncharacterized protein; Belongs to the cytochrome P450 family. (483 aa)
MVDDiphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. (400 aa)
DHCR2424-dehydrocholesterol reductase. (516 aa)
H3AD94_LATCHZgc:194242. (210 aa)
HMGCS13-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (525 aa)
CYP39A1Cytochrome P450 family 39 subfamily A member 1; Belongs to the cytochrome P450 family. (457 aa)
TM7SF2Transmembrane 7 superfamily member 2. (354 aa)
CYP7A1Cytochrome P450 family 7 subfamily A member 1. (514 aa)
LOC102346667Uncharacterized protein; Belongs to the cytochrome P450 family. (497 aa)
FDFT1Farnesyl-diphosphate farnesyltransferase 1. (416 aa)
STSSteroid sulfatase. (471 aa)
H3AHQ6_LATCHEBP cholestenol delta-isomerase. (131 aa)
CYP4V2Cytochrome P450 family 4 subfamily V member 2; Belongs to the cytochrome P450 family. (521 aa)
LOC102364638Uncharacterized protein; Belongs to the cytochrome P450 family. (536 aa)
AKR1D1Aldo-keto reductase family 1 member D1. (326 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (882 aa)
LOC102347924Si:ch211-113j14.1; Belongs to the cytochrome P450 family. (520 aa)
CYP19A1Cytochrome P450 family 19 subfamily A member 1. (443 aa)
LOC102362530Uncharacterized protein; Belongs to the cytochrome P450 family. (540 aa)
CYP2R1Cytochrome P450 family 2 subfamily R member 1; Belongs to the cytochrome P450 family. (439 aa)
H3APN0_LATCHUncharacterized protein; Belongs to the cytochrome P450 family. (491 aa)
RUSC1RUN and SH3 domain containing 1. (800 aa)
LSSTerpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family. (735 aa)
LOC102350971Uncharacterized protein; Belongs to the cytochrome P450 family. (504 aa)
SOAT1O-acyltransferase. (545 aa)
LOC102360223Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (509 aa)
LOC102347380Cytochrome P450, family 1, subfamily D, polypeptide 1; Belongs to the cytochrome P450 family. (520 aa)
AACSAcetoacetyl-CoA synthetase. (670 aa)
H3AT94_LATCHUncharacterized protein; Belongs to the cytochrome P450 family. (381 aa)
LOC102363496SE domain-containing protein. (479 aa)
HSD17B7Hydroxysteroid 17-beta dehydrogenase 7. (330 aa)
LOC102363771SE domain-containing protein. (566 aa)
GGPS1Geranylgeranyl diphosphate synthase 1; Belongs to the FPP/GGPP synthase family. (338 aa)
SRD5A3Steroid 5 alpha-reductase 3. (314 aa)
LOC102364039SE domain-containing protein. (552 aa)
H3AZM3_LATCHUncharacterized protein. (349 aa)
LOC102364287SE domain-containing protein. (433 aa)
UGT1A1UDP glucuronosyltransferase family 1 member A1; Belongs to the UDP-glycosyltransferase family. (538 aa)
LOC102345423Uncharacterized protein; Belongs to the cytochrome P450 family. (474 aa)
LOC102346130Uncharacterized protein; Belongs to the cytochrome P450 family. (518 aa)
H3B0V4_LATCHUncharacterized protein. (518 aa)
CYP20A1Cytochrome P450 family 20 subfamily A member 1. (463 aa)
LOC102357693Cytochrome P450, family 1, subfamily A; Belongs to the cytochrome P450 family. (520 aa)
CYP24A1Cytochrome P450 family 24 subfamily A member 1; Belongs to the cytochrome P450 family. (505 aa)
LOC102364376Uncharacterized protein; Belongs to the cytochrome P450 family. (513 aa)
CYP27C1Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family. (466 aa)
LOC102354597Cholesterol 25-hydroxylase like 1, tandem duplicate 2; Belongs to the sterol desaturase family. (293 aa)
LOC102349366Cholesterol 25-hydroxylase like 1, tandem duplicate 1; Belongs to the sterol desaturase family. (271 aa)
ACAT2Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (401 aa)
LOC102345588Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1; Belongs to the 3-beta-HSD family. (377 aa)
DHCR77-dehydrocholesterol reductase. (478 aa)
CYP46A1Cytochrome P450 family 46 subfamily A member 1. (505 aa)
H3B8W8_LATCHUncharacterized protein; Belongs to the cytochrome P450 family. (214 aa)
LOC102362765Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (537 aa)
R3HDM4R3H domain containing 4. (259 aa)
LOC102363927Uncharacterized protein. (461 aa)
SOAT2O-acyltransferase. (507 aa)
LOC102349421Cytochrome P450, family 1, subfamily C, polypeptide 2; Belongs to the cytochrome P450 family. (528 aa)
PTGISProstaglandin I2 synthase; Belongs to the cytochrome P450 family. (506 aa)
LOC102357152Uncharacterized protein; Belongs to the cytochrome P450 family. (479 aa)
CYP27A1Cytochrome P450 family 27 subfamily A member 1; Belongs to the cytochrome P450 family. (539 aa)
CCDC160Coiled-coil domain containing 160. (326 aa)
CYP27B1Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (502 aa)
PORNADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (676 aa)
HSD11B1Hydroxysteroid 11-beta dehydrogenase 1. (293 aa)
FAXDC2Fatty acid hydroxylase domain containing 2; Belongs to the sterol desaturase family. (337 aa)
ERG28Ergosterol biosynthesis 28 homolog. (143 aa)
MVKMevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (401 aa)
SRD5A13-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (261 aa)
LOC102365730Uncharacterized protein; Belongs to the cytochrome P450 family. (503 aa)
EAF2-2Si:dkey-91i10.3; Belongs to the cytochrome P450 family. (555 aa)
HSD17B3Hydroxysteroid 17-beta dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (315 aa)
SC5DSterol-C5-desaturase; Belongs to the sterol desaturase family. (299 aa)
SRD5A23-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (254 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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