(57 nodes) Mixed, incl. Sterol biosynthetic process, and Synthesis of bile acids and bile salts via 27-hydroxycholesterol network (Latimeria chalumnae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	LOC102349382	Methyltransf_11 domain-containing protein. (238 aa)
	LOC102361952	Uncharacterized protein; Belongs to the cytochrome P450 family. (212 aa)
	IDI1	Isopentenyl-diphosphate delta isomerase 1. (278 aa)
	LIPA	Lipase; Belongs to the AB hydrolase superfamily. Lipase family. (398 aa)
	HSD3B7	Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7; Belongs to the 3-beta-HSD family. (377 aa)
	LOC102363673	Sulfotransferase; Belongs to the sulfotransferase 1 family. (247 aa)
	SQLE	SE domain-containing protein. (506 aa)
	NSDHL	NAD(P) dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family. (340 aa)
	PMVK	Phosphomevalonate kinase. (188 aa)
	LOC102357417	Uncharacterized protein; Belongs to the cytochrome P450 family. (512 aa)
	SDR42E1	Short chain dehydrogenase/reductase family 42E, member 1. (409 aa)
	CH25H	Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. (284 aa)
	SULT2B1	Sulfotransferase; Belongs to the sulfotransferase 1 family. (296 aa)
	CYP51A1	Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family. (508 aa)
	SIGMAR1	Sigma non-opioid intracellular receptor 1. (223 aa)
	LOC102352197	Methyltranfer_dom domain-containing protein. (272 aa)
	CYP7B1	Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (480 aa)
	LOC102354799	Uncharacterized protein; Belongs to the cytochrome P450 family. (483 aa)
	MVD	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. (400 aa)
	DHCR24	24-dehydrocholesterol reductase. (516 aa)
	H3AD94_LATCH	Zgc:194242. (210 aa)
	HMGCS1	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (525 aa)
	TM7SF2	Transmembrane 7 superfamily member 2. (354 aa)
	CYP7A1	Cytochrome P450 family 7 subfamily A member 1. (514 aa)
	FDFT1	Farnesyl-diphosphate farnesyltransferase 1. (416 aa)
	STS	Steroid sulfatase. (471 aa)
	H3AHQ6_LATCH	EBP cholestenol delta-isomerase. (131 aa)
	HMGCR	3-hydroxy-3-methylglutaryl coenzyme A reductase. (882 aa)
	LOC102347924	Si:ch211-113j14.1; Belongs to the cytochrome P450 family. (520 aa)
	RUSC1	RUN and SH3 domain containing 1. (800 aa)
	LSS	Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family. (735 aa)
	SOAT1	O-acyltransferase. (545 aa)
	LOC102360223	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (509 aa)
	AACS	Acetoacetyl-CoA synthetase. (670 aa)
	LOC102363496	SE domain-containing protein. (479 aa)
	HSD17B7	Hydroxysteroid 17-beta dehydrogenase 7. (330 aa)
	LOC102363771	SE domain-containing protein. (566 aa)
	GGPS1	Geranylgeranyl diphosphate synthase 1; Belongs to the FPP/GGPP synthase family. (338 aa)
	LOC102364039	SE domain-containing protein. (552 aa)
	LOC102364287	SE domain-containing protein. (433 aa)
	LOC102364376	Uncharacterized protein; Belongs to the cytochrome P450 family. (513 aa)
	LOC102354597	Cholesterol 25-hydroxylase like 1, tandem duplicate 2; Belongs to the sterol desaturase family. (293 aa)
	LOC102349366	Cholesterol 25-hydroxylase like 1, tandem duplicate 1; Belongs to the sterol desaturase family. (271 aa)
	ACAT2	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (401 aa)
	LOC102345588	Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1; Belongs to the 3-beta-HSD family. (377 aa)
	DHCR7	7-dehydrocholesterol reductase. (478 aa)
	CYP46A1	Cytochrome P450 family 46 subfamily A member 1. (505 aa)
	R3HDM4	R3H domain containing 4. (259 aa)
	SOAT2	O-acyltransferase. (507 aa)
	PTGIS	Prostaglandin I2 synthase; Belongs to the cytochrome P450 family. (506 aa)
	CYP27A1	Cytochrome P450 family 27 subfamily A member 1; Belongs to the cytochrome P450 family. (539 aa)
	CCDC160	Coiled-coil domain containing 160. (326 aa)
	FAXDC2	Fatty acid hydroxylase domain containing 2; Belongs to the sterol desaturase family. (337 aa)
	ERG28	Ergosterol biosynthesis 28 homolog. (143 aa)
	MVK	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (401 aa)
	EAF2-2	Si:dkey-91i10.3; Belongs to the cytochrome P450 family. (555 aa)
	SC5D	Sterol-C5-desaturase; Belongs to the sterol desaturase family. (299 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AACS	ACAT2	ENSLACP00000012849	ENSLACP00000017009	Acetoacetyl-CoA synthetase.	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	0.754
AACS	CYP51A1	ENSLACP00000012849	ENSLACP00000004316	Acetoacetyl-CoA synthetase.	Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family.	0.408
AACS	HMGCR	ENSLACP00000012849	ENSLACP00000010356	Acetoacetyl-CoA synthetase.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.519
AACS	HMGCS1	ENSLACP00000012849	ENSLACP00000007791	Acetoacetyl-CoA synthetase.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.594
AACS	LOC102363496	ENSLACP00000012849	ENSLACP00000012939	Acetoacetyl-CoA synthetase.	SE domain-containing protein.	0.418
AACS	LOC102363771	ENSLACP00000012849	ENSLACP00000013829	Acetoacetyl-CoA synthetase.	SE domain-containing protein.	0.418
AACS	LOC102364039	ENSLACP00000012849	ENSLACP00000014761	Acetoacetyl-CoA synthetase.	SE domain-containing protein.	0.418
AACS	LOC102364287	ENSLACP00000012849	ENSLACP00000015136	Acetoacetyl-CoA synthetase.	SE domain-containing protein.	0.418
AACS	LSS	ENSLACP00000012849	ENSLACP00000011792	Acetoacetyl-CoA synthetase.	Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family.	0.613
AACS	MVK	ENSLACP00000012849	ENSLACP00000022534	Acetoacetyl-CoA synthetase.	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.495
AACS	PMVK	ENSLACP00000012849	ENSLACP00000002032	Acetoacetyl-CoA synthetase.	Phosphomevalonate kinase.	0.458
AACS	RUSC1	ENSLACP00000012849	ENSLACP00000011787	Acetoacetyl-CoA synthetase.	RUN and SH3 domain containing 1.	0.586
AACS	SQLE	ENSLACP00000012849	ENSLACP00000001476	Acetoacetyl-CoA synthetase.	SE domain-containing protein.	0.418
ACAT2	AACS	ENSLACP00000017009	ENSLACP00000012849	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	Acetoacetyl-CoA synthetase.	0.754
ACAT2	CH25H	ENSLACP00000017009	ENSLACP00000003985	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family.	0.423
ACAT2	CYP51A1	ENSLACP00000017009	ENSLACP00000004316	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family.	0.576
ACAT2	DHCR24	ENSLACP00000017009	ENSLACP00000007383	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	24-dehydrocholesterol reductase.	0.691
ACAT2	DHCR7	ENSLACP00000017009	ENSLACP00000017855	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	7-dehydrocholesterol reductase.	0.714
ACAT2	FDFT1	ENSLACP00000017009	ENSLACP00000008630	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	Farnesyl-diphosphate farnesyltransferase 1.	0.580
ACAT2	GGPS1	ENSLACP00000017009	ENSLACP00000014085	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	Geranylgeranyl diphosphate synthase 1; Belongs to the FPP/GGPP synthase family.	0.420