(24 nodes) Notch signaling pathway, and Presenilin, C-terminal network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102353790	Uncharacterized protein. (899 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1220 aa)
	H2ZYW6_LATCH	Uncharacterized protein. (543 aa)
	MAML2	Mastermind like transcriptional coactivator 2. (954 aa)
	NOTCH3	Notch receptor 3. (1577 aa)
	RBPJL	Recombination signal binding protein for immunoglobulin kappa J region like. (512 aa)
	RBPJ	Recombination signal binding protein for immunoglobulin kappa J region. (487 aa)
	DLL3	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (699 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
	H3AJI4_LATCH	Uncharacterized protein. (272 aa)
	PSENEN	Presenilin enhancer, gamma-secretase subunit. (101 aa)
	H3AML2_LATCH	Uncharacterized protein. (627 aa)
	NCSTN	Nicastrin. (680 aa)
	LOC102360420	Uncharacterized protein. (264 aa)
	MAML3	Mastermind like transcriptional coactivator 3. (943 aa)
	MAML1	Mastermind like transcriptional coactivator 1. (1039 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (465 aa)
	APH1B	Aph-1 homolog B, gamma-secretase subunit. (258 aa)
	DLL4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (688 aa)
	LOC102357987	Uncharacterized protein. (2519 aa)
	JAG2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1106 aa)
	PSEN2	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (458 aa)
	NOTCH1	Notch receptor 1. (2494 aa)
	NOTCH2	Notch receptor 2. (2489 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APH1B	LOC102353790	ENSLACP00000013738	ENSLACP00000000182	Aph-1 homolog B, gamma-secretase subunit.	Uncharacterized protein.	0.915
APH1B	LOC102357987	ENSLACP00000013738	ENSLACP00000014598	Aph-1 homolog B, gamma-secretase subunit.	Uncharacterized protein.	0.942
APH1B	LOC102360420	ENSLACP00000013738	ENSLACP00000011952	Aph-1 homolog B, gamma-secretase subunit.	Uncharacterized protein.	0.901
APH1B	NCSTN	ENSLACP00000013738	ENSLACP00000010981	Aph-1 homolog B, gamma-secretase subunit.	Nicastrin.	0.989
APH1B	NOTCH1	ENSLACP00000013738	ENSLACP00000020474	Aph-1 homolog B, gamma-secretase subunit.	Notch receptor 1.	0.446
APH1B	NOTCH2	ENSLACP00000013738	ENSLACP00000022069	Aph-1 homolog B, gamma-secretase subunit.	Notch receptor 2.	0.908
APH1B	NOTCH3	ENSLACP00000013738	ENSLACP00000003701	Aph-1 homolog B, gamma-secretase subunit.	Notch receptor 3.	0.915
APH1B	PSEN1	ENSLACP00000013738	ENSLACP00000012775	Aph-1 homolog B, gamma-secretase subunit.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.906
APH1B	PSEN2	ENSLACP00000013738	ENSLACP00000019297	Aph-1 homolog B, gamma-secretase subunit.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.885
APH1B	PSENEN	ENSLACP00000013738	ENSLACP00000010134	Aph-1 homolog B, gamma-secretase subunit.	Presenilin enhancer, gamma-secretase subunit.	0.988
DLL1	DLL3	ENSLACP00000009351	ENSLACP00000008690	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.904
DLL1	DLL4	ENSLACP00000009351	ENSLACP00000013765	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.937
DLL1	H2ZYW6_LATCH	ENSLACP00000009351	ENSLACP00000002587	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.633
DLL1	H3AML2_LATCH	ENSLACP00000009351	ENSLACP00000010883	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.579
DLL1	JAG1	ENSLACP00000009351	ENSLACP00000001302	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.524
DLL1	JAG2	ENSLACP00000009351	ENSLACP00000014617	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.417
DLL1	LOC102353790	ENSLACP00000009351	ENSLACP00000000182	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.974
DLL1	LOC102357987	ENSLACP00000009351	ENSLACP00000014598	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.984
DLL1	MAML1	ENSLACP00000009351	ENSLACP00000012398	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Mastermind like transcriptional coactivator 1.	0.411
DLL1	MAML2	ENSLACP00000009351	ENSLACP00000003327	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Mastermind like transcriptional coactivator 2.	0.413