(15 nodes) Delta serrate ligand, and Notch network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102353790	Uncharacterized protein. (899 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1220 aa)
	MAML2	Mastermind like transcriptional coactivator 2. (954 aa)
	NOTCH3	Notch receptor 3. (1577 aa)
	RBPJL	Recombination signal binding protein for immunoglobulin kappa J region like. (512 aa)
	RBPJ	Recombination signal binding protein for immunoglobulin kappa J region. (487 aa)
	DLL3	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (699 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
	MAML3	Mastermind like transcriptional coactivator 3. (943 aa)
	MAML1	Mastermind like transcriptional coactivator 1. (1039 aa)
	DLL4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (688 aa)
	LOC102357987	Uncharacterized protein. (2519 aa)
	JAG2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1106 aa)
	NOTCH1	Notch receptor 1. (2494 aa)
	NOTCH2	Notch receptor 2. (2489 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DLL1	DLL3	ENSLACP00000009351	ENSLACP00000008690	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.904
DLL1	DLL4	ENSLACP00000009351	ENSLACP00000013765	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.937
DLL1	JAG1	ENSLACP00000009351	ENSLACP00000001302	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.524
DLL1	JAG2	ENSLACP00000009351	ENSLACP00000014617	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.417
DLL1	LOC102353790	ENSLACP00000009351	ENSLACP00000000182	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.974
DLL1	LOC102357987	ENSLACP00000009351	ENSLACP00000014598	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.984
DLL1	MAML1	ENSLACP00000009351	ENSLACP00000012398	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Mastermind like transcriptional coactivator 1.	0.411
DLL1	MAML2	ENSLACP00000009351	ENSLACP00000003327	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Mastermind like transcriptional coactivator 2.	0.413
DLL1	NOTCH1	ENSLACP00000009351	ENSLACP00000020474	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 1.	0.848
DLL1	NOTCH2	ENSLACP00000009351	ENSLACP00000022069	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 2.	0.962
DLL1	NOTCH3	ENSLACP00000009351	ENSLACP00000003701	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 3.	0.974
DLL1	RBPJ	ENSLACP00000009351	ENSLACP00000008245	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Recombination signal binding protein for immunoglobulin kappa J region.	0.637
DLL1	RBPJL	ENSLACP00000009351	ENSLACP00000006489	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Recombination signal binding protein for immunoglobulin kappa J region like.	0.454
DLL3	DLL1	ENSLACP00000008690	ENSLACP00000009351	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.904
DLL3	DLL4	ENSLACP00000008690	ENSLACP00000013765	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.938
DLL3	JAG1	ENSLACP00000008690	ENSLACP00000001302	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.486
DLL3	LOC102353790	ENSLACP00000008690	ENSLACP00000000182	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.973
DLL3	LOC102357987	ENSLACP00000008690	ENSLACP00000014598	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.984
DLL3	MAML1	ENSLACP00000008690	ENSLACP00000012398	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Mastermind like transcriptional coactivator 1.	0.411
DLL3	MAML2	ENSLACP00000008690	ENSLACP00000003327	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Mastermind like transcriptional coactivator 2.	0.413