(5 nodes) Delta serrate ligand, and Noncanonical activation of NOTCH3 network (Latimeria chalumnae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102353790	Uncharacterized protein. (899 aa)
	DLL3	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (699 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
	DLL4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (688 aa)
	NOTCH2	Notch receptor 2. (2489 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DLL1	DLL3	ENSLACP00000009351	ENSLACP00000008690	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.904
DLL1	DLL4	ENSLACP00000009351	ENSLACP00000013765	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.937
DLL1	LOC102353790	ENSLACP00000009351	ENSLACP00000000182	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.974
DLL1	NOTCH2	ENSLACP00000009351	ENSLACP00000022069	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 2.	0.962
DLL3	DLL1	ENSLACP00000008690	ENSLACP00000009351	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.904
DLL3	DLL4	ENSLACP00000008690	ENSLACP00000013765	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.938
DLL3	LOC102353790	ENSLACP00000008690	ENSLACP00000000182	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.973
DLL3	NOTCH2	ENSLACP00000008690	ENSLACP00000022069	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 2.	0.956
DLL4	DLL1	ENSLACP00000013765	ENSLACP00000009351	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.937
DLL4	DLL3	ENSLACP00000013765	ENSLACP00000008690	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.938
DLL4	LOC102353790	ENSLACP00000013765	ENSLACP00000000182	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.981
DLL4	NOTCH2	ENSLACP00000013765	ENSLACP00000022069	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 2.	0.960
LOC102353790	DLL1	ENSLACP00000000182	ENSLACP00000009351	Uncharacterized protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.974
LOC102353790	DLL3	ENSLACP00000000182	ENSLACP00000008690	Uncharacterized protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.973
LOC102353790	DLL4	ENSLACP00000000182	ENSLACP00000013765	Uncharacterized protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.981
NOTCH2	DLL1	ENSLACP00000022069	ENSLACP00000009351	Notch receptor 2.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.962
NOTCH2	DLL3	ENSLACP00000022069	ENSLACP00000008690	Notch receptor 2.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.956
NOTCH2	DLL4	ENSLACP00000022069	ENSLACP00000013765	Notch receptor 2.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.960