(95 nodes) Mixed, incl. Cadherin conserved site, and Formation of the cornified envelope network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102351486	Uncharacterized protein. (614 aa)
	CALHM6	Calcium homeostasis modulator family member 6. (322 aa)
	H2ZTV2_LATCH	Uncharacterized protein. (383 aa)
	CCBE1	Collagen and calcium binding EGF domains 1. (357 aa)
	CDH8	Cadherin 8; Cadherins are calcium-dependent cell adhesion proteins. (713 aa)
	CDH18	Cadherin 18; Cadherins are calcium-dependent cell adhesion proteins. (791 aa)
	CLCA4	Chloride channel accessory 1. (866 aa)
	ACOT11	Acyl-CoA thioesterase 11. (569 aa)
	RNF152	Ring finger protein 152. (203 aa)
	H2ZY56_LATCH	Uncharacterized protein. (127 aa)
	CALHM5	Calcium homeostasis modulator family member 5. (309 aa)
	CDH6	Cadherin 6; Cadherins are calcium-dependent cell adhesion proteins. (791 aa)
	FAT3	Uncharacterized protein. (3096 aa)
	LOC102361492	Uncharacterized protein. (1086 aa)
	LIX1	Limb and CNS expressed 1. (282 aa)
	H3A003_LATCH	Uncharacterized protein. (1739 aa)
	H3A0S9_LATCH	Uncharacterized protein; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (898 aa)
	CDH12	Cadherin 12; Cadherins are calcium-dependent cell adhesion proteins. (727 aa)
	LOC102357073	Uncharacterized protein. (927 aa)
	PCDH9	Protocadherin 9. (1032 aa)
	H3A3F8_LATCH	Uncharacterized protein. (381 aa)
	H3A4U8_LATCH	Uncharacterized protein. (2171 aa)
	CTNNA3	Uncharacterized protein. (213 aa)
	CDH4	Cadherin 4; Cadherins are calcium-dependent cell adhesion proteins. (724 aa)
	KAZN-2	Uncharacterized protein. (125 aa)
	ARHGAP21	Rho GTPase activating protein 21. (1978 aa)
	LOC102361769	Uncharacterized protein. (924 aa)
	H3A7F2_LATCH	Uncharacterized protein. (620 aa)
	CDH11	Cadherin 11; Cadherins are calcium-dependent cell adhesion proteins. (800 aa)
	DSP	Desmoplakin. (2623 aa)
	CDH1	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (829 aa)
	JUP	Junction plakoglobin. (694 aa)
	ISLR	Immunoglobulin superfamily containing leucine rich repeat. (673 aa)
	H3ABH6_LATCH	Uncharacterized protein. (808 aa)
	PCDH7	Protocadherin 7b. (1051 aa)
	LOC102346231	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (714 aa)
	H3ADZ2_LATCH	Si:dkey-78a14.4; Belongs to the arylamine N-acetyltransferase family. (294 aa)
	H3AEB9_LATCH	Cadherin_tail domain-containing protein. (123 aa)
	TMEM215	Transmembrane protein 215. (225 aa)
	CDH15	Cadherin 15; Cadherins are calcium-dependent cell adhesion proteins. (797 aa)
	CTF1	Cardiotrophin 1. (183 aa)
	H3AHF5_LATCH	Uncharacterized protein. (1088 aa)
	LOC102354257	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (789 aa)
	C5orf22	Chromosome 5 open reading frame 22. (459 aa)
	H3AIL3_LATCH	Uncharacterized protein. (1683 aa)
	BRINP3	BMP/retinoic acid inducible neural specific 3. (766 aa)
	KAZN	Uncharacterized protein. (640 aa)
	RUBCNL	Rubicon like autophagy enhancer. (468 aa)
	FAT4	FAT atypical cadherin 4. (3207 aa)
	PIEZO1	Piezo-type mechanosensitive ion channel component. (2125 aa)
	H3AQR1_LATCH	Uncharacterized protein. (586 aa)
	PCDH20	Uncharacterized protein. (875 aa)
	H3ARS9_LATCH	Uncharacterized protein. (86 aa)
	C1orf109	Chromosome 1 open reading frame 109. (204 aa)
	RIPPLY2	Ripply transcriptional repressor 2. (131 aa)
	CDH5	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (772 aa)
	CDH16	Cadherin 16, KSP-cadherin. (839 aa)
	H3AU51_LATCH	Uncharacterized protein. (706 aa)
	PKP1	Plakophilin 1. (744 aa)
	CTNND2	Uncharacterized protein. (368 aa)
	H3AUF0_LATCH	Fibrinogen C-terminal domain-containing protein. (239 aa)
	DCHS1	Uncharacterized protein. (608 aa)
	H3AWS2_LATCH	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (310 aa)
	SNED1-2	Uncharacterized protein. (271 aa)
	H3AXL4_LATCH	Uncharacterized protein. (953 aa)
	UGT3A2	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (422 aa)
	H3AZ26_LATCH	Uncharacterized protein. (79 aa)
	CTNNAL1	Catenin alpha like 1. (674 aa)
	LOC102361707	P53 apoptosis effector related to pmp22. (183 aa)
	LOC102361982	Uncharacterized protein. (182 aa)
	H3B296_LATCH	Uncharacterized protein. (380 aa)
	LIX1L	Limb and CNS expressed 1 like. (345 aa)
	CDH7	Cadherin 7; Cadherins are calcium-dependent cell adhesion proteins. (785 aa)
	CDH24	Cadherin 24; Cadherins are calcium-dependent cell adhesion proteins. (784 aa)
	H3B4B5_LATCH	Uncharacterized protein. (534 aa)
	PIR	Pirin; Belongs to the pirin family. (171 aa)
	LGALSL	Galectin. (170 aa)
	PCDH11Y	Protocadherin 11. (1013 aa)
	ARVCF	ARVCF delta catenin family member. (870 aa)
	GMIP	GEM interacting protein. (962 aa)
	EVPL	Envoplakin a. (2004 aa)
	LOC102358216	Uncharacterized protein. (809 aa)
	FAT2	Uncharacterized protein. (1744 aa)
	LOC102357400	Uncharacterized protein. (814 aa)
	FAM20B	FAM20B glycosaminoglycan xylosylkinase. (409 aa)
	CEP162	Centrosomal protein 162. (1442 aa)
	VEGFC	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (410 aa)
	M3XIR5_LATCH	Uncharacterized protein. (217 aa)
	CDH2	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (894 aa)
	M3XJ81_LATCH	Uncharacterized protein. (117 aa)
	ADAMTS3	ADAM metallopeptidase with thrombospondin type 1 motif 3. (1195 aa)
	SLC36A1	Solute carrier family 36 member 1. (390 aa)
	LOC102345355	Uncharacterized protein. (276 aa)
	PKP2	Uncharacterized protein. (815 aa)
	PKP4	Plakophilin 4. (1190 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACOT11	C1orf109	ENSLACP00000001570	ENSLACP00000012455	Acyl-CoA thioesterase 11.	Chromosome 1 open reading frame 109.	0.665
ACOT11	C5orf22	ENSLACP00000001570	ENSLACP00000009362	Acyl-CoA thioesterase 11.	Chromosome 5 open reading frame 22.	0.448
ACOT11	CALHM5	ENSLACP00000001570	ENSLACP00000002401	Acyl-CoA thioesterase 11.	Calcium homeostasis modulator family member 5.	0.476
ACOT11	CALHM6	ENSLACP00000001570	ENSLACP00000000768	Acyl-CoA thioesterase 11.	Calcium homeostasis modulator family member 6.	0.476
ACOT11	CLCA4	ENSLACP00000001570	ENSLACP00000001529	Acyl-CoA thioesterase 11.	Chloride channel accessory 1.	0.455
ACOT11	H3A3F8_LATCH	ENSLACP00000001570	ENSLACP00000004179	Acyl-CoA thioesterase 11.	Uncharacterized protein.	0.455
ACOT11	LIX1	ENSLACP00000001570	ENSLACP00000002774	Acyl-CoA thioesterase 11.	Limb and CNS expressed 1.	0.543
ACOT11	LIX1L	ENSLACP00000001570	ENSLACP00000016190	Acyl-CoA thioesterase 11.	Limb and CNS expressed 1 like.	0.543
ACOT11	RUBCNL	ENSLACP00000001570	ENSLACP00000011793	Acyl-CoA thioesterase 11.	Rubicon like autophagy enhancer.	0.665
ADAMTS3	CCBE1	ENSLACP00000023080	ENSLACP00000001053	ADAM metallopeptidase with thrombospondin type 1 motif 3.	Collagen and calcium binding EGF domains 1.	0.613
ADAMTS3	FAT4	ENSLACP00000023080	ENSLACP00000011804	ADAM metallopeptidase with thrombospondin type 1 motif 3.	FAT atypical cadherin 4.	0.520
ADAMTS3	PIEZO1	ENSLACP00000023080	ENSLACP00000011837	ADAM metallopeptidase with thrombospondin type 1 motif 3.	Piezo-type mechanosensitive ion channel component.	0.476
ADAMTS3	VEGFC	ENSLACP00000023080	ENSLACP00000022599	ADAM metallopeptidase with thrombospondin type 1 motif 3.	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family.	0.425
ARHGAP21	CEP162	ENSLACP00000005209	ENSLACP00000022092	Rho GTPase activating protein 21.	Centrosomal protein 162.	0.576
ARHGAP21	PIEZO1	ENSLACP00000005209	ENSLACP00000011837	Rho GTPase activating protein 21.	Piezo-type mechanosensitive ion channel component.	0.573
ARVCF	CDH1	ENSLACP00000019051	ENSLACP00000006055	ARVCF delta catenin family member.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.832
ARVCF	CDH11	ENSLACP00000019051	ENSLACP00000005664	ARVCF delta catenin family member.	Cadherin 11; Cadherins are calcium-dependent cell adhesion proteins.	0.662
ARVCF	CDH12	ENSLACP00000019051	ENSLACP00000003276	ARVCF delta catenin family member.	Cadherin 12; Cadherins are calcium-dependent cell adhesion proteins.	0.619
ARVCF	CDH15	ENSLACP00000019051	ENSLACP00000008616	ARVCF delta catenin family member.	Cadherin 15; Cadherins are calcium-dependent cell adhesion proteins.	0.681
ARVCF	CDH16	ENSLACP00000019051	ENSLACP00000013008	ARVCF delta catenin family member.	Cadherin 16, KSP-cadherin.	0.678