(41 nodes) Wnt signaling pathway network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ROR2	Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (882 aa)
	RYK	Receptor like tyrosine kinase. (542 aa)
	H2ZYH3_LATCH	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	H3A4P0_LATCH	Ig-like domain-containing protein. (174 aa)
	WLS	Wnt ligand secretion mediator. (541 aa)
	WNT7A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
	WNT9B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	SFRP2	Secreted frizzled related protein 2. (294 aa)
	WNT16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
	PORCN	Porcupine O-acyltransferase; Belongs to the membrane-bound acyltransferase family. (463 aa)
	WNT3	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (331 aa)
	SFRP1	NTR domain-containing protein. (128 aa)
	ROR1	Receptor tyrosine kinase like orphan receptor 1. (769 aa)
	SFRP1-2	FZ domain-containing protein. (203 aa)
	WIF1	WNT inhibitory factor 1. (379 aa)
	FZD3	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (604 aa)
	H3AXS1_LATCH	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (313 aa)
	FZD1	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (557 aa)
	LOC102359071	Uncharacterized protein. (297 aa)
	SFRP5	Secreted frizzled related protein 5. (309 aa)
	FZD7	Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (555 aa)
	FZD6	Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
	WNT8A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
	WNT4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	H3B5C9_LATCH	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
	LOC102363206	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (575 aa)
	WNT9A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (341 aa)
	WNT10A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (387 aa)
	WNT6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (348 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa)
	WNT5B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (378 aa)
	FZD2	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (552 aa)
	WNT2B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	WNT8B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (432 aa)
	FZD10	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (580 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (373 aa)
	LOC102350297	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	WNT10B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FZD1	FZD3	ENSLACP00000014874	ENSLACP00000012917	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	0.436
FZD1	FZD6	ENSLACP00000014874	ENSLACP00000016182	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family.	0.509
FZD1	H2ZYH3_LATCH	ENSLACP00000014874	ENSLACP00000002444	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.837
FZD1	H3A4P0_LATCH	ENSLACP00000014874	ENSLACP00000004611	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Ig-like domain-containing protein.	0.462
FZD1	H3AXS1_LATCH	ENSLACP00000014874	ENSLACP00000014442	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.656
FZD1	H3B5C9_LATCH	ENSLACP00000014874	ENSLACP00000017100	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.795
FZD1	LOC102350297	ENSLACP00000014874	ENSLACP00000021630	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.801
FZD1	LOC102359071	ENSLACP00000014874	ENSLACP00000014878	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Uncharacterized protein.	0.650
FZD1	ROR1	ENSLACP00000014874	ENSLACP00000010024	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Receptor tyrosine kinase like orphan receptor 1.	0.943
FZD1	ROR2	ENSLACP00000014874	ENSLACP00000001497	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.	0.516
FZD1	RYK	ENSLACP00000014874	ENSLACP00000001511	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Receptor like tyrosine kinase.	0.918
FZD1	SFRP1-2	ENSLACP00000014874	ENSLACP00000011164	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	FZ domain-containing protein.	0.665
FZD1	SFRP2	ENSLACP00000014874	ENSLACP00000007301	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled related protein 2.	0.692
FZD1	SFRP5	ENSLACP00000014874	ENSLACP00000015584	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled related protein 5.	0.665
FZD1	WNT1	ENSLACP00000014874	ENSLACP00000021628	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.889
FZD1	WNT10A	ENSLACP00000014874	ENSLACP00000019163	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.761
FZD1	WNT10B	ENSLACP00000014874	ENSLACP00000021631	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.761
FZD1	WNT11	ENSLACP00000014874	ENSLACP00000006775	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.968
FZD1	WNT16	ENSLACP00000014874	ENSLACP00000008361	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.787
FZD1	WNT2	ENSLACP00000014874	ENSLACP00000017997	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.862