(23 nodes) Wnt, and Frizzled/Smoothened, transmembrane domain network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RYK	Receptor like tyrosine kinase. (542 aa)
	H2ZYH3_LATCH	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	WNT7A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
	WNT9B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	SFRP2	Secreted frizzled related protein 2. (294 aa)
	WNT16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
	WIF1	WNT inhibitory factor 1. (379 aa)
	FZD3	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (604 aa)
	FZD1	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (557 aa)
	SFRP5	Secreted frizzled related protein 5. (309 aa)
	FZD6	Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
	WNT4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	H3B5C9_LATCH	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
	LOC102363206	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (575 aa)
	WNT10A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (387 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa)
	WNT5B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (378 aa)
	FZD2	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (552 aa)
	FZD10	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (580 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (373 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FZD1	FZD3	ENSLACP00000014874	ENSLACP00000012917	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	0.436
FZD1	FZD6	ENSLACP00000014874	ENSLACP00000016182	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family.	0.509
FZD1	H2ZYH3_LATCH	ENSLACP00000014874	ENSLACP00000002444	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.837
FZD1	H3B5C9_LATCH	ENSLACP00000014874	ENSLACP00000017100	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.795
FZD1	RYK	ENSLACP00000014874	ENSLACP00000001511	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Receptor like tyrosine kinase.	0.918
FZD1	SFRP2	ENSLACP00000014874	ENSLACP00000007301	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled related protein 2.	0.692
FZD1	SFRP5	ENSLACP00000014874	ENSLACP00000015584	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled related protein 5.	0.665
FZD1	WNT1	ENSLACP00000014874	ENSLACP00000021628	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.889
FZD1	WNT10A	ENSLACP00000014874	ENSLACP00000019163	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.761
FZD1	WNT11	ENSLACP00000014874	ENSLACP00000006775	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.968
FZD1	WNT16	ENSLACP00000014874	ENSLACP00000008361	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.787
FZD1	WNT2	ENSLACP00000014874	ENSLACP00000017997	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.862
FZD1	WNT3A	ENSLACP00000014874	ENSLACP00000019786	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.850
FZD1	WNT4	ENSLACP00000014874	ENSLACP00000017017	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.837
FZD1	WNT5A	ENSLACP00000014874	ENSLACP00000006595	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.870
FZD1	WNT5B	ENSLACP00000014874	ENSLACP00000020257	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.892
FZD1	WNT7A	ENSLACP00000014874	ENSLACP00000006054	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.806
FZD1	WNT9B	ENSLACP00000014874	ENSLACP00000006321	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.762
FZD10	FZD3	ENSLACP00000021475	ENSLACP00000012917	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	0.481
FZD10	FZD6	ENSLACP00000021475	ENSLACP00000016182	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family.	0.504