STRINGSTRING
H2ZRI4_LATCH H2ZRI4_LATCH WWTR1 WWTR1 CCN2 CCN2 CHRD CHRD LOC102361521 LOC102361521 LOC102351518 LOC102351518 LOC102353315 LOC102353315 LOC102361851 LOC102361851 LOC102360469 LOC102360469 BMPR1B BMPR1B FAM181B FAM181B LOC102353671 LOC102353671 LOC102346204 LOC102346204 BMPR1A BMPR1A DDR1 DDR1 LOC102348752 LOC102348752 BMP3 BMP3 BMP10 BMP10 ACVR2A ACVR2A DTX4 DTX4 WWC3 WWC3 DCHS2 DCHS2 STK4 STK4 NEDD4L NEDD4L LOC102350164 LOC102350164 ARRDC3 ARRDC3 WWP1 WWP1 RNF111 RNF111 YAP1 YAP1 CBLN2 CBLN2 WWTR1-2 WWTR1-2 TGFBR2 TGFBR2 KCNA5 KCNA5 H3A5S4_LATCH H3A5S4_LATCH H3A657_LATCH H3A657_LATCH WFIKKN2 WFIKKN2 LOC102356523 LOC102356523 INHBA INHBA RNF13 RNF13 SMAD6 SMAD6 FNDC9 FNDC9 GDF7 GDF7 SMAD7 SMAD7 PLEKHH1 PLEKHH1 GDF6 GDF6 TMEFF2 TMEFF2 GREM1 GREM1 TGFBR3 TGFBR3 H3AC83_LATCH H3AC83_LATCH H3ACJ0_LATCH H3ACJ0_LATCH LOC102350981 LOC102350981 KIAA0513 KIAA0513 H3ADJ9_LATCH H3ADJ9_LATCH TGFB2 TGFB2 TDGF1 TDGF1 TGFBR1 TGFBR1 SMAD5 SMAD5 WWP2 WWP2 NOG NOG TBX15 TBX15 VGLL4 VGLL4 LOC102365261 LOC102365261 LOC102351081 LOC102351081 GRAMD2B GRAMD2B LOC102359411 LOC102359411 ACVR1C ACVR1C H3AIA4_LATCH H3AIA4_LATCH LOC102357009 LOC102357009 ANKFN1 ANKFN1 SCNN1A SCNN1A TWSG1 TWSG1 LOC102357456 LOC102357456 LATS2 LATS2 ZFYVE16 ZFYVE16 HECW2 HECW2 TEAD2 TEAD2 GDF5 GDF5 FSTL3 FSTL3 H3AMK9_LATCH H3AMK9_LATCH H3AN17_LATCH H3AN17_LATCH LOC102350996 LOC102350996 MOB1B MOB1B LATS1 LATS1 ACVR1 ACVR1 NBL1 NBL1 SMAD3 SMAD3 SYNJ2BP SYNJ2BP IVNS1ABP IVNS1ABP ANGPTL1 ANGPTL1 BMP6 BMP6 SMAD9 SMAD9 ZFYVE9 ZFYVE9 SMAD1 SMAD1 PTPN14 PTPN14 LOC102357384 LOC102357384 AMOTL2 AMOTL2 METTL21C-2 METTL21C-2 LOC102358054 LOC102358054 SCNN1G SCNN1G ANKRD1 ANKRD1 H3AV24_LATCH H3AV24_LATCH LOC102358352 LOC102358352 ACVR2B ACVR2B SCNN1B SCNN1B H3AVW8_LATCH H3AVW8_LATCH ATP13A3 ATP13A3 LOC102365514 LOC102365514 FST FST SAV1 SAV1 AMOTL1 AMOTL1 ASIC4 ASIC4 SIM2 SIM2 AMOT AMOT TEAD1 TEAD1 GREM2 GREM2 SKI SKI PEBP4 PEBP4 WWC2 WWC2 SH2D3C SH2D3C LOC102363737 LOC102363737 SLC25A37 SLC25A37 BMP2 BMP2 GDF3 GDF3 LOC102357703 LOC102357703 STK3 STK3 SMURF2 SMURF2 ZIC3 ZIC3 SKIL SKIL ARRDC1 ARRDC1 BMPR2 BMPR2 MSTN MSTN RNF44 RNF44 INHA INHA NEDD4 NEDD4 INHBB INHBB H3B8I8_LATCH H3B8I8_LATCH NODAL NODAL SYNGR2 SYNGR2 FIBCD1 FIBCD1 FEZ1 FEZ1 GDF2 GDF2 GDF10 GDF10 TGFB3 TGFB3 PPM1D PPM1D H3BBK8_LATCH H3BBK8_LATCH IRF2BP2 IRF2BP2 LOC102352268 LOC102352268 LOC102361854 LOC102361854 BMP7 BMP7 FGFBP3 FGFBP3 H3BEX6_LATCH H3BEX6_LATCH SDF2 SDF2 DTX2 DTX2 LOC102356073 LOC102356073 UBE2J2 UBE2J2 SCNN1D SCNN1D ACAP3 ACAP3 LOC102355265 LOC102355265 LOC102355609 LOC102355609 LOC102355877 LOC102355877 ITCH ITCH BMP4 BMP4 ACVRL1 ACVRL1 ACVR1B ACVR1B GAS2L3 GAS2L3 SLC25A39 SLC25A39 LOC102358988 LOC102358988 CENPT CENPT BMPER BMPER ACP4 ACP4 LOC102356233 LOC102356233 LOC102364358 LOC102364358 NF2 NF2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
H2ZRI4_LATCHUncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (213 aa)
WWTR1WW domain containing transcription regulator 1. (264 aa)
CCN2Cellular communication network factor 2. (344 aa)
CHRDChordin; Belongs to the chordin family. (948 aa)
LOC102361521Uncharacterized protein. (123 aa)
LOC102351518Left-right determination factor. (364 aa)
LOC102353315Uncharacterized protein. (381 aa)
LOC102361851Paraoxonase 1. (364 aa)
LOC102360469Noggin; Belongs to the noggin family. (211 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
FAM181BFamily with sequence similarity 181 member B. (328 aa)
LOC102353671Uncharacterized protein. (1052 aa)
LOC102346204Protein kinase domain-containing protein. (227 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (530 aa)
DDR1Discoidin domain receptor tyrosine kinase 1. (964 aa)
LOC102348752Microtubule associated tumor suppressor 1a. (330 aa)
BMP3Bone morphogenetic protein 3. (365 aa)
BMP10Bone morphogenetic protein 10. (405 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
DTX4Deltex E3 ubiquitin ligase 4. (599 aa)
WWC3WWC family member 3. (1172 aa)
DCHS2Uncharacterized protein. (3211 aa)
STK4Serine/threonine kinase 4. (488 aa)
NEDD4LE3 ubiquitin-protein ligase. (876 aa)
LOC102350164Uncharacterized protein. (364 aa)
ARRDC3Arrestin domain containing 3. (414 aa)
WWP1E3 ubiquitin-protein ligase. (922 aa)
RNF111Ring finger protein 111. (966 aa)
YAP1Yes associated protein 1. (324 aa)
CBLN2Cerebellin 2 precursor. (203 aa)
WWTR1-2WW domain-containing protein. (159 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (585 aa)
KCNA5Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (573 aa)
H3A5S4_LATCHUncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (200 aa)
H3A657_LATCHPH domain-containing protein. (1101 aa)
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2. (575 aa)
LOC102356523Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (510 aa)
INHBAInhibin subunit beta A. (390 aa)
RNF13Ring finger protein 13. (381 aa)
SMAD6Mothers against decapentaplegic homolog. (485 aa)
FNDC9Uncharacterized protein. (197 aa)
GDF7Growth differentiation factor 7. (416 aa)
SMAD7Mothers against decapentaplegic homolog. (377 aa)
PLEKHH1Pleckstrin homology, MyTH4 and FERM domain containing H1. (1450 aa)
GDF6Growth differentiation factor 6a. (408 aa)
TMEFF2Transmembrane protein with EGF like and two follistatin like domains 2. (372 aa)
GREM1Gremlin 1, DAN family BMP antagonist. (189 aa)
TGFBR3Transforming growth factor beta receptor 3. (808 aa)
H3AC83_LATCHUncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (202 aa)
H3ACJ0_LATCHCellular communication network factor 2b. (348 aa)
LOC102350981Uncharacterized protein. (695 aa)
KIAA0513KIAA0513. (412 aa)
H3ADJ9_LATCHUncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (189 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
TDGF1EGF-like domain-containing protein. (154 aa)
TGFBR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
SMAD5Mothers against decapentaplegic homolog. (467 aa)
WWP2E3 ubiquitin-protein ligase. (883 aa)
NOGNoggin; Belongs to the noggin family. (223 aa)
TBX15T-box transcription factor 15. (566 aa)
VGLL4Vestigial like family member 4. (293 aa)
LOC102365261Fibrinogen silencer binding protein. (307 aa)
LOC102351081Bone morphogenetic protein 16. (396 aa)
GRAMD2BGRAM domain containing 2B. (433 aa)
LOC102359411Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (322 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (453 aa)
H3AIA4_LATCHUncharacterized protein. (405 aa)
LOC102357009Southpaw. (414 aa)
ANKFN1Ankyrin repeat and fibronectin type III domain containing 1. (558 aa)
SCNN1ASodium channel epithelial 1 alpha subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (653 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (220 aa)
LOC102357456Uncharacterized protein. (202 aa)
LATS2Large tumor suppressor kinase 2. (1108 aa)
ZFYVE16Zinc finger FYVE domain-containing protein. (1493 aa)
HECW2HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2. (1586 aa)
TEAD2TEA domain-containing protein. (356 aa)
GDF5Growth differentiation factor 5. (501 aa)
FSTL3Follistatin like 3. (248 aa)
H3AMK9_LATCHUncharacterized protein. (229 aa)
H3AN17_LATCHUncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (158 aa)
LOC102350996MOB kinase activator 1A. (216 aa)
MOB1BMOB kinase activator 1B. (217 aa)
LATS1Large tumor suppressor kinase 1. (1140 aa)
ACVR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
NBL1NBL1, DAN family BMP antagonist. (184 aa)
SMAD3Mothers against decapentaplegic homolog. (358 aa)
SYNJ2BPPDZ domain-containing protein. (107 aa)
IVNS1ABPInfluenza virus NS1A binding protein. (645 aa)
ANGPTL1Angiopoietin like 1. (493 aa)
BMP6Bone morphogenetic protein 6. (428 aa)
SMAD9Mothers against decapentaplegic homolog. (467 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1429 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
PTPN14Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (1086 aa)
LOC102357384Noggin; Belongs to the noggin family. (216 aa)
AMOTL2Angiomotin like 2. (766 aa)
METTL21C-2Zgc:92518. (241 aa)
LOC102358054Bone morphogenetic protein 8a. (420 aa)
SCNN1GSodium channel epithelial 1 gamma subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (661 aa)
ANKRD1Ankyrin repeat domain 1. (319 aa)
H3AV24_LATCHUncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (195 aa)
LOC102358352TGF_BETA_2 domain-containing protein. (365 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (515 aa)
SCNN1BSodium channel epithelial 1 beta subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (650 aa)
H3AVW8_LATCHMothers against decapentaplegic homolog. (369 aa)
ATP13A3Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1232 aa)
LOC102365514Uncharacterized protein. (375 aa)
FSTFollistatin. (319 aa)
SAV1Salvador family WW domain containing protein 1. (393 aa)
AMOTL1Angiomotin like 1. (940 aa)
ASIC4Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (351 aa)
SIM2SIM bHLH transcription factor 2. (708 aa)
AMOTAngiomotin. (855 aa)
TEAD1TEA domain transcription factor 1. (458 aa)
GREM2Gremlin 2, DAN family BMP antagonist. (167 aa)
SKISKI proto-oncogene. (702 aa)
PEBP4Phosphatidylethanolamine binding protein 4. (204 aa)
WWC2WW and C2 domain containing 2. (1138 aa)
SH2D3CSH2 domain containing 3C. (730 aa)
LOC102363737Uncharacterized protein. (229 aa)
SLC25A37Solute carrier family 25 member 37; Belongs to the mitochondrial carrier (TC 2.A.29) family. (268 aa)
BMP2Bone morphogenetic protein 2. (402 aa)
GDF3Growth differentiation factor 3. (381 aa)
LOC102357703Laminin, beta 2-like. (1836 aa)
STK3Serine/threonine kinase 3. (213 aa)
SMURF2E3 ubiquitin-protein ligase. (754 aa)
ZIC3Zic family member 3. (445 aa)
SKILSKI like proto-oncogene. (691 aa)
ARRDC1Arrestin domain containing 1. (427 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1037 aa)
MSTNMyostatin. (372 aa)
RNF44Ring finger protein 44. (446 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (345 aa)
NEDD4NEDD4 E3 ubiquitin protein ligase. (1313 aa)
INHBBInhibin subunit beta B. (393 aa)
H3B8I8_LATCHFibronectin type-III domain-containing protein. (174 aa)
NODALTGF_BETA_2 domain-containing protein. (409 aa)
SYNGR2Synaptogyrin. (223 aa)
FIBCD1Fibrinogen C domain containing 1. (438 aa)
FEZ1Fasciculation and elongation protein zeta 1. (393 aa)
GDF2Growth differentiation factor 2. (431 aa)
GDF10Growth differentiation factor 10. (440 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (409 aa)
PPM1DProtein phosphatase, Mg2+/Mn2+ dependent 1D. (636 aa)
H3BBK8_LATCHUncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (188 aa)
IRF2BP2Interferon regulatory factor 2 binding protein 2. (522 aa)
LOC102352268Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
LOC102361854Anti-dorsalizing morphogenic protein. (394 aa)
BMP7Bone morphogenetic protein 7. (425 aa)
FGFBP3Fibroblast growth factor binding protein 3. (239 aa)
H3BEX6_LATCHReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (307 aa)
SDF2Stromal cell derived factor 2. (225 aa)
DTX2Deltex E3 ubiquitin ligase 2. (628 aa)
LOC102356073CTCK domain-containing protein. (167 aa)
UBE2J2Ubiquitin conjugating enzyme E2 J2. (272 aa)
SCNN1DSodium channel epithelial 1 delta subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (565 aa)
ACAP3ArfGAP with coiled-coil, ankyrin repeat and PH domains 3. (558 aa)
LOC102355265Neurofibromin 2b (merlin). (577 aa)
LOC102355609TGF_BETA_2 domain-containing protein. (385 aa)
LOC102355877TGF_BETA_2 domain-containing protein. (359 aa)
ITCHE3 ubiquitin-protein ligase. (880 aa)
BMP4Bone morphogenetic protein 4. (460 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (497 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (489 aa)
GAS2L3Uncharacterized protein. (769 aa)
SLC25A39Solute carrier family 25 member 39; Belongs to the mitochondrial carrier (TC 2.A.29) family. (358 aa)
LOC102358988Mothers against decapentaplegic homolog. (614 aa)
CENPTUncharacterized protein. (809 aa)
BMPERBMP binding endothelial regulator. (682 aa)
ACP4Uncharacterized protein; Belongs to the histidine acid phosphatase family. (414 aa)
LOC102356233TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (574 aa)
LOC102364358TEA domain-containing protein. (362 aa)
NF2Neurofibromin 2. (595 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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