(118 nodes) Protein folding, and DnaJ molecular chaperone homology domain network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PLAAT1	Phospholipase A and acyltransferase 1. (168 aa)
	PJA2	Uncharacterized protein. (546 aa)
	LOC102357218	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1. (730 aa)
	LOC102367489	Uncharacterized protein. (173 aa)
	DNAJC2	DnaJ heat shock protein family (Hsp40) member C2. (620 aa)
	HSPA8	Uncharacterized protein; Belongs to the heat shock protein 70 family. (645 aa)
	LOC102367553	Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family. (646 aa)
	DNAJB1	DnaJ heat shock protein family (Hsp40) member B1. (341 aa)
	HSCB	HscB mitochondrial iron-sulfur cluster cochaperone. (257 aa)
	BBS10	Bardet-Biedl syndrome 10. (714 aa)
	DNAJB13	DnaJ heat shock protein family (Hsp40) member B13. (319 aa)
	NKTR	Natural killer cell triggering receptor. (1510 aa)
	CCT5	Chaperonin containing TCP1 subunit 5. (554 aa)
	DNAJA2	DnaJ heat shock protein family (Hsp40) member A2. (366 aa)
	DNAJC3	DnaJ heat shock protein family (Hsp40) member C3. (513 aa)
	H3A382_LATCH	Reverse transcriptase domain-containing protein. (680 aa)
	HSPBP1	HSPA (Hsp70) binding protein 1. (328 aa)
	DNAJA1	DnaJ heat shock protein family (Hsp40) member A1. (359 aa)
	DNAJC8	DnaJ heat shock protein family (Hsp40) member C8. (276 aa)
	SUGT1	SGT1 homolog, MIS12 kinetochore complex assembly cochaperone. (336 aa)
	DNAJA3	DnaJ heat shock protein family (Hsp40) member A3. (480 aa)
	H3A6Y2_LATCH	Uncharacterized protein. (564 aa)
	LOC102359772	DnaJ (Hsp40) homolog, subfamily C, member 3b. (478 aa)
	BAG2	BCL2 associated athanogene 2. (212 aa)
	CCT2	Chaperonin containing TCP1 subunit 2. (535 aa)
	HSP90B1	Heat shock protein 90 beta family member 1. (800 aa)
	CDC37L1	Cell division cycle 37 like 1. (326 aa)
	DNAJB14	DnaJ heat shock protein family (Hsp40) member B14. (381 aa)
	HSPA12A	Heat shock protein family A (Hsp70) member 12A. (665 aa)
	DNAJA4	DnaJ heat shock protein family (Hsp40) member A4. (396 aa)
	DNAJC5B	DnaJ heat shock protein family (Hsp40) member C5 beta. (197 aa)
	MKKS	McKusick-Kaufman syndrome. (575 aa)
	DNAJC1	DnaJ heat shock protein family (Hsp40) member C1. (540 aa)
	LOC102353228	Uncharacterized protein; Belongs to the heat shock protein 70 family. (648 aa)
	BAG1	BCL2 associated athanogene 1. (207 aa)
	GRPEL2	GrpE like 2, mitochondrial; Belongs to the GrpE family. (225 aa)
	HSPA12B	Heat shock protein family A (Hsp70) member 12B. (680 aa)
	DNAJB2	DnaJ heat shock protein family (Hsp40) member B2. (299 aa)
	TMEM59L	Transmembrane protein 59 like. (340 aa)
	CCT8	Chaperonin containing TCP1 subunit 8. (557 aa)
	H3AFR4_LATCH	Peptidylprolyl isomerase. (467 aa)
	DNAJC7	DnaJ heat shock protein family (Hsp40) member C7. (492 aa)
	PFDN2	Prefoldin subunit 2. (109 aa)
	DNAJC25	DnaJ (Hsp40) homolog, subfamily C, member 25. (353 aa)
	DNAJC9	DnaJ heat shock protein family (Hsp40) member C9. (261 aa)
	HSPA13	Heat shock protein family A (Hsp70) member 13. (326 aa)
	DNAJB11	DnaJ heat shock protein family (Hsp40) member B11. (299 aa)
	PFDN6	Prefoldin subunit 6. (126 aa)
	CLPB	ClpB homolog, mitochondrial AAA ATPase chaperonin. (425 aa)
	CDC37	Cell division cycle 37. (382 aa)
	PDCL3	Phosducin like 3. (237 aa)
	ERMARD	Uncharacterized protein. (108 aa)
	HSPA9	Heat shock protein family A (Hsp70) member 9; Belongs to the heat shock protein 70 family. (647 aa)
	CCT3	T-complex protein 1 subunit gamma. (548 aa)
	ARHGAP28	Rho GTPase activating protein 28. (691 aa)
	H3ANH1_LATCH	Uncharacterized protein. (256 aa)
	BAG5	BCL2 associated athanogene 5. (460 aa)
	DNAJB9	DnaJ heat shock protein family (Hsp40) member B9. (219 aa)
	HSPA4	Heat shock protein family A (Hsp70) member 4. (783 aa)
	CCT7	T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. (561 aa)
	HSPA14	Heat shock protein 14; Belongs to the heat shock protein 70 family. (510 aa)
	HSP90AB1	Heat shock protein 90 alpha family class B member 1. (734 aa)
	STUB1	STIP1 homology and U-box containing protein 1. (289 aa)
	H3AQM4_LATCH	Uncharacterized protein. (301 aa)
	ITGB1BP2	Integrin subunit beta 1 binding protein 2. (354 aa)
	GRPEL1	GrpE protein homolog; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the GrpE family. (220 aa)
	VBP1-2	Prefoldin subunit 3; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins; Belongs to the prefoldin subunit alpha family. (204 aa)
	DNAJC5G	J domain-containing protein. (116 aa)
	C10orf71	DUF4585 domain-containing protein. (1398 aa)
	TTC28	TPR_REGION domain-containing protein. (2002 aa)
	PDCD5	Programmed cell death 5. (128 aa)
	LOC102357450	Uncharacterized protein; Belongs to the heat shock protein 70 family. (641 aa)
	LOC102350076	HSF_DOMAIN domain-containing protein. (453 aa)
	TXNDC9	Thioredoxin domain containing 9. (225 aa)
	TRAP1	TNF receptor associated protein 1. (718 aa)
	DNAJB4	DnaJ heat shock protein family (Hsp40) member B4. (343 aa)
	DNAJC27	DnaJ heat shock protein family (Hsp40) member C27. (273 aa)
	NR3C2	Uncharacterized protein. (611 aa)
	DNAJC24	DnaJ heat shock protein family (Hsp40) member C24. (149 aa)
	LOC102363778	J domain-containing protein. (211 aa)
	PFDN4	Prefoldin subunit 4; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins; Belongs to the prefoldin subunit beta family. (134 aa)
	H3B2N1_LATCH	NACHT domain-containing protein. (429 aa)
	H3B2N9_LATCH	Uncharacterized protein. (185 aa)
	PPID	Peptidylprolyl isomerase D. (309 aa)
	PDCL2	Phosducin like 2. (177 aa)
	HSP90AA1	Heat shock protein 90 alpha family class A member 1. (725 aa)
	PFDN5	Prefoldin subunit 5. (155 aa)
	MAPT	Microtubule-associated protein. (436 aa)
	LOC102351854	Uncharacterized protein; Belongs to the heat shock protein 70 family. (641 aa)
	TCP1	T-complex 1. (559 aa)
	AR	Androgen receptor. (412 aa)
	LOC102359148	Uncharacterized protein; Belongs to the heat shock protein 70 family. (584 aa)
	LOC102361687	Uncharacterized protein. (188 aa)
	HSPD1	Heat shock protein family D (Hsp60) member 1; Belongs to the chaperonin (HSP60) family. (565 aa)
	HSPE1	Heat shock protein family E (Hsp10) member 1; Belongs to the GroES chaperonin family. (114 aa)
	NR3C1	Nuclear receptor subfamily 3 group C member 1. (770 aa)
	DNAJC11	DnaJ heat shock protein family (Hsp40) member C11. (564 aa)
	H3B866_LATCH	TPR_REGION domain-containing protein. (110 aa)
	AHSA1	Activator of HSP90 ATPase activity 1. (341 aa)
	VBP1	Prefoldin subunit 3; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins; Belongs to the prefoldin subunit alpha family. (195 aa)
	HSPA4L	Heat shock protein family A (Hsp70) member 4 like. (845 aa)
	STIP1	Stress induced phosphoprotein 1. (576 aa)
	LOC102350613	Uncharacterized protein. (402 aa)
	DNAJB12	DnaJ heat shock protein family (Hsp40) member B12. (389 aa)
	HYOU1	Hypoxia up-regulated 1. (993 aa)
	CCT4	T-complex protein 1 subunit delta. (535 aa)
	HSPA5	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family. (654 aa)
	DNAJC16	DnaJ heat shock protein family (Hsp40) member C16. (782 aa)
	DNAJC30	DnaJ heat shock protein family (Hsp40) member C30. (218 aa)
	PTGES3	Prostaglandin E synthase 3. (161 aa)
	DNAJC14	J domain-containing protein. (603 aa)
	CCT6B	Chaperonin containing TCP1 subunit 6B. (536 aa)
	DNAJC22	DnaJ heat shock protein family (Hsp40) member C22. (340 aa)
	DNAJB5	DnaJ heat shock protein family (Hsp40) member B5. (348 aa)
	FKBP5	Peptidylprolyl isomerase. (460 aa)
	ZPBP2	Ig-like domain-containing protein. (330 aa)
	FAM161A	FAM161 centrosomal protein A. (680 aa)
	M3XLG5_LATCH	Uncharacterized protein. (384 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AHSA1	C10orf71	ENSLACP00000018090	ENSLACP00000012714	Activator of HSP90 ATPase activity 1.	DUF4585 domain-containing protein.	0.406
AHSA1	CCT2	ENSLACP00000018090	ENSLACP00000005828	Activator of HSP90 ATPase activity 1.	Chaperonin containing TCP1 subunit 2.	0.402
AHSA1	CCT3	ENSLACP00000018090	ENSLACP00000010673	Activator of HSP90 ATPase activity 1.	T-complex protein 1 subunit gamma.	0.402
AHSA1	CCT5	ENSLACP00000018090	ENSLACP00000002511	Activator of HSP90 ATPase activity 1.	Chaperonin containing TCP1 subunit 5.	0.486
AHSA1	CCT7	ENSLACP00000018090	ENSLACP00000011702	Activator of HSP90 ATPase activity 1.	T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.	0.671
AHSA1	CCT8	ENSLACP00000018090	ENSLACP00000008299	Activator of HSP90 ATPase activity 1.	Chaperonin containing TCP1 subunit 8.	0.471
AHSA1	CDC37	ENSLACP00000018090	ENSLACP00000009880	Activator of HSP90 ATPase activity 1.	Cell division cycle 37.	0.757
AHSA1	CDC37L1	ENSLACP00000018090	ENSLACP00000005854	Activator of HSP90 ATPase activity 1.	Cell division cycle 37 like 1.	0.619
AHSA1	CLPB	ENSLACP00000018090	ENSLACP00000009565	Activator of HSP90 ATPase activity 1.	ClpB homolog, mitochondrial AAA ATPase chaperonin.	0.740
AHSA1	DNAJA1	ENSLACP00000018090	ENSLACP00000004746	Activator of HSP90 ATPase activity 1.	DnaJ heat shock protein family (Hsp40) member A1.	0.556
AHSA1	DNAJA2	ENSLACP00000018090	ENSLACP00000002651	Activator of HSP90 ATPase activity 1.	DnaJ heat shock protein family (Hsp40) member A2.	0.556
AHSA1	DNAJA3	ENSLACP00000018090	ENSLACP00000005367	Activator of HSP90 ATPase activity 1.	DnaJ heat shock protein family (Hsp40) member A3.	0.581
AHSA1	DNAJA4	ENSLACP00000018090	ENSLACP00000006389	Activator of HSP90 ATPase activity 1.	DnaJ heat shock protein family (Hsp40) member A4.	0.556
AHSA1	DNAJB1	ENSLACP00000018090	ENSLACP00000001606	Activator of HSP90 ATPase activity 1.	DnaJ heat shock protein family (Hsp40) member B1.	0.613
AHSA1	DNAJB13	ENSLACP00000018090	ENSLACP00000002136	Activator of HSP90 ATPase activity 1.	DnaJ heat shock protein family (Hsp40) member B13.	0.613
AHSA1	DNAJB2	ENSLACP00000018090	ENSLACP00000007287	Activator of HSP90 ATPase activity 1.	DnaJ heat shock protein family (Hsp40) member B2.	0.458
AHSA1	DNAJB4	ENSLACP00000018090	ENSLACP00000014689	Activator of HSP90 ATPase activity 1.	DnaJ heat shock protein family (Hsp40) member B4.	0.613
AHSA1	DNAJB5	ENSLACP00000018090	ENSLACP00000022000	Activator of HSP90 ATPase activity 1.	DnaJ heat shock protein family (Hsp40) member B5.	0.611
AHSA1	DNAJB9	ENSLACP00000018090	ENSLACP00000011504	Activator of HSP90 ATPase activity 1.	DnaJ heat shock protein family (Hsp40) member B9.	0.611
AHSA1	DNAJC16	ENSLACP00000018090	ENSLACP00000020804	Activator of HSP90 ATPase activity 1.	DnaJ heat shock protein family (Hsp40) member C16.	0.435