(115 nodes) U2-type spliceosomal complex, and mRNA Splicing - Major Pathway network (Latimeria chalumnae)

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Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	H2ZRU8_LATCH	RRM domain-containing protein. (441 aa)
	SNRNP200	Small nuclear ribonucleoprotein U5 subunit 200. (1764 aa)
	TXNL4A	Thioredoxin like 4A. (63 aa)
	TXNL4A-2	Uncharacterized protein. (105 aa)
	PLRG1	Pleiotropic regulator 1. (514 aa)
	SF3B5	Splicing factor 3B subunit 5; Belongs to the SF3B5 family. (86 aa)
	ZMAT2	Zinc finger matrin-type 2. (199 aa)
	CRNKL1	Crooked neck pre-mRNA splicing factor 1. (684 aa)
	H2ZW06_LATCH	RRM domain-containing protein. (1590 aa)
	CWC25	CWC25 spliceosome associated protein homolog. (319 aa)
	DHX8	DEAH-box helicase 8. (1211 aa)
	TXNL4B	Thioredoxin-like protein; Plays role in pre-mRNA splicing. Belongs to the DIM1 family. (149 aa)
	SNRPD1	Small nuclear ribonucleoprotein Sm D1; Essential for pre-mRNA splicing. Implicated in the formation of stable, biologically active snRNP structures. Belongs to the snRNP core protein family. (121 aa)
	DHX16	DEAH-box helicase 16. (593 aa)
	SDE2	SDE2 telomere maintenance homolog. (418 aa)
	H2ZZC6_LATCH	Sm domain-containing protein. (117 aa)
	USP39	Ubiquitin specific peptidase 39. (522 aa)
	XAB2	XPA binding protein 2. (848 aa)
	H3A2E3_LATCH	G patch domain and KOW motifs. (273 aa)
	PRPF19	Pre-mRNA processing factor 19. (504 aa)
	FAM32A	Family with sequence similarity 32 member A. (97 aa)
	SF3A1	Splicing factor 3a subunit 1. (787 aa)
	SF3B4	Splicing factor 3b subunit 4. (363 aa)
	LOC102356421	ISY1 splicing factor homolog. (282 aa)
	SNRPD2	Small nuclear ribonucleoprotein Sm D2. (108 aa)
	SMU1	SMU1 DNA replication regulator and spliceosomal factor. (513 aa)
	CWC27	CWC27 spliceosome associated cyclophilin. (473 aa)
	CTNNBL1	Catenin beta like 1. (563 aa)
	WDR25	WD repeat domain 25. (288 aa)
	IK	IK cytokine. (571 aa)
	DAW1	Dynein assembly factor with WD repeats 1. (415 aa)
	CWC22	CWC22 spliceosome associated protein homolog. (1120 aa)
	C9orf78	Chromosome 9 open reading frame 78. (287 aa)
	TCERG1	Transcription elongation regulator 1. (1012 aa)
	YJU2	YJU2 splicing factor homolog. (346 aa)
	RBMX2	RRM domain-containing protein. (400 aa)
	LSM6	LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated. (80 aa)
	DHX15	DEAH-box helicase 15. (765 aa)
	SNRPB2	Small nuclear ribonucleoprotein polypeptide B2. (229 aa)
	SART3	Spliceosome associated factor 3, U4/U6 recycling protein. (720 aa)
	SF3A3	Splicing factor 3a subunit 3. (354 aa)
	DDX46	DEAD-box helicase 46. (1026 aa)
	SRRM3	Serine/arginine repetitive matrix 3. (594 aa)
	CDC5L	Cell division cycle 5 like. (803 aa)
	NKAPL	NFKB activating protein like. (385 aa)
	SF3A2	Splicing factor 3a subunit 2. (313 aa)
	WBP4	WW domain binding protein 4. (402 aa)
	TFIP11	Tuftelin-interacting protein 11; Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Belongs to the TFP11/STIP family. (832 aa)
	PRPF31	Pre-mRNA processing factor 31. (496 aa)
	CWF19L2	CWF19 like cell cycle control factor 2. (905 aa)
	PRPF18	PRP18 pre-mRNA processing factor 18 homolog (yeast). (351 aa)
	SLU7	SLU7 homolog, splicing factor. (586 aa)
	LSM8	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. (96 aa)
	SF3B2	Splicing factor 3b subunit 2. (892 aa)
	PRPF8	Pre-mRNA processing factor 8. (2213 aa)
	PRPF3	Pre-mRNA processing factor 3. (631 aa)
	HFM1	Helicase for meiosis 1. (1059 aa)
	LSM1	U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs. (121 aa)
	SART1	Spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP. (649 aa)
	PPIE	Peptidyl-prolyl cis-trans isomerase E; Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins; Belongs to the cyclophilin-type PPIase family. PPIase E subfamily. (302 aa)
	CDC40	Cell division cycle 40. (574 aa)
	BUD31	BUD31 homolog. (238 aa)
	SNRPB	Small nuclear ribonucleoprotein-associated protein. (240 aa)
	PRPF38A	Pre-mRNA processing factor 38A. (312 aa)
	AQR	Aquarius intron-binding spliceosomal factor. (1464 aa)
	SYF2	SYF2 pre-mRNA splicing factor. (238 aa)
	PHF5A	PHD finger protein 5A. (93 aa)
	CWC15	CWC15 spliceosome associated protein homolog. (232 aa)
	LOC102358785	Uncharacterized protein. (196 aa)
	SF3B3	Splicing factor 3b subunit 3. (1205 aa)
	SNRPE	Small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family. (93 aa)
	PPIG	Peptidylprolyl isomerase G. (677 aa)
	EFTUD2	Elongation factor Tu GTP binding domain containing 2. (971 aa)
	DHX38	DEAH-box helicase 38. (1221 aa)
	SRRM2	Cwf21 domain-containing protein. (909 aa)
	RNF113A	Ring finger protein 113A. (346 aa)
	FAM50A	Family with sequence similarity 50 member A. (343 aa)
	SNW1	SNW domain containing 1. (536 aa)
	DDX42	DEAD-box helicase 42. (923 aa)
	PPWD1	Peptidylprolyl isomerase domain and WD repeat containing 1. (629 aa)
	SF3B6	Splicing factor 3b subunit 6. (125 aa)
	DHX34	DExH-box helicase 34. (989 aa)
	BUD13	BUD13 homolog. (812 aa)
	PPIL2	Peptidylprolyl isomerase like 2. (525 aa)
	NSRP1	Nuclear speckle splicing regulatory protein 1. (552 aa)
	CACTIN	Cactin, spliceosome C complex subunit. (768 aa)
	SRRM1	Serine and arginine repetitive matrix 1. (924 aa)
	SF3B1	Splicing factor 3b subunit 1. (1308 aa)
	MFAP1	Microfibril associated protein 1. (442 aa)
	LSM2	U6 snRNA-associated Sm-like protein LSm2; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (95 aa)
	SNRPD3	Small nuclear ribonucleoprotein Sm D3. (126 aa)
	UBL5	Ubiquitin like 5. (73 aa)
	PPIL3	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (185 aa)
	LSM11	LSM11, U7 small nuclear RNA associated. (338 aa)
	LSM7	LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated. (103 aa)
	LSM4	U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (140 aa)
	LSM10	LSM10, U7 small nuclear RNA associated. (130 aa)
	PRPF4	Pre-mRNA processing factor 4. (523 aa)
	PPIL4	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. (495 aa)
	ZCCHC17	Zinc finger CCHC-type containing 17. (234 aa)
	SNRNP40	Small nuclear ribonucleoprotein U5 subunit 40. (350 aa)
	DDX23	DEAD-box helicase 23; Belongs to the DEAD box helicase family. (751 aa)
	SNIP1	Smad nuclear interacting protein 1. (376 aa)
	SNRNP27	Small nuclear ribonucleoprotein U4/U6.U5 subunit 27. (133 aa)
	PRKRIP1	PRKR interacting protein 1. (184 aa)
	C19orf54	Chromosome 19 open reading frame 54. (311 aa)
	SNRPA	Small nuclear ribonucleoprotein polypeptide A. (279 aa)
	SNRPG	Small nuclear ribonucleoprotein G. (76 aa)
	PPIL1	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (166 aa)
	PPIH	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (174 aa)
	DHX33	DEAH-box helicase 33. (680 aa)
	SNRPA1	Small nuclear ribonucleoprotein polypeptide A. (256 aa)
	BCAS2	BCAS2 pre-mRNA processing factor. (248 aa)
	LSM5	U6 snRNA-associated Sm-like protein LSm5; Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA. (91 aa)
	LOC106703418	Ig-like domain-containing protein. (335 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AQR	BCAS2	ENSLACP00000013678	ENSLACP00000020905	Aquarius intron-binding spliceosomal factor.	BCAS2 pre-mRNA processing factor.	0.978
AQR	BUD13	ENSLACP00000013678	ENSLACP00000016543	Aquarius intron-binding spliceosomal factor.	BUD13 homolog.	0.558
AQR	BUD31	ENSLACP00000013678	ENSLACP00000012914	Aquarius intron-binding spliceosomal factor.	BUD31 homolog.	0.997
AQR	CACTIN	ENSLACP00000013678	ENSLACP00000016783	Aquarius intron-binding spliceosomal factor.	Cactin, spliceosome C complex subunit.	0.547
AQR	CDC40	ENSLACP00000013678	ENSLACP00000012800	Aquarius intron-binding spliceosomal factor.	Cell division cycle 40.	0.997
AQR	CDC5L	ENSLACP00000013678	ENSLACP00000009131	Aquarius intron-binding spliceosomal factor.	Cell division cycle 5 like.	0.998
AQR	CRNKL1	ENSLACP00000013678	ENSLACP00000001259	Aquarius intron-binding spliceosomal factor.	Crooked neck pre-mRNA splicing factor 1.	0.998
AQR	CTNNBL1	ENSLACP00000013678	ENSLACP00000005558	Aquarius intron-binding spliceosomal factor.	Catenin beta like 1.	0.547
AQR	CWC15	ENSLACP00000013678	ENSLACP00000013903	Aquarius intron-binding spliceosomal factor.	CWC15 spliceosome associated protein homolog.	0.926
AQR	CWC22	ENSLACP00000013678	ENSLACP00000006671	Aquarius intron-binding spliceosomal factor.	CWC22 spliceosome associated protein homolog.	0.871
AQR	CWC25	ENSLACP00000013678	ENSLACP00000001952	Aquarius intron-binding spliceosomal factor.	CWC25 spliceosome associated protein homolog.	0.555
AQR	CWC27	ENSLACP00000013678	ENSLACP00000005544	Aquarius intron-binding spliceosomal factor.	CWC27 spliceosome associated cyclophilin.	0.707
AQR	CWF19L2	ENSLACP00000013678	ENSLACP00000011140	Aquarius intron-binding spliceosomal factor.	CWF19 like cell cycle control factor 2.	0.900
AQR	DHX15	ENSLACP00000013678	ENSLACP00000008161	Aquarius intron-binding spliceosomal factor.	DEAH-box helicase 15.	0.836
AQR	DHX16	ENSLACP00000013678	ENSLACP00000002740	Aquarius intron-binding spliceosomal factor.	DEAH-box helicase 16.	0.732
AQR	DHX33	ENSLACP00000013678	ENSLACP00000020684	Aquarius intron-binding spliceosomal factor.	DEAH-box helicase 33.	0.542
AQR	DHX34	ENSLACP00000013678	ENSLACP00000016367	Aquarius intron-binding spliceosomal factor.	DExH-box helicase 34.	0.749
AQR	DHX38	ENSLACP00000013678	ENSLACP00000014777	Aquarius intron-binding spliceosomal factor.	DEAH-box helicase 38.	0.584
AQR	DHX8	ENSLACP00000013678	ENSLACP00000001975	Aquarius intron-binding spliceosomal factor.	DEAH-box helicase 8.	0.934
AQR	EFTUD2	ENSLACP00000013678	ENSLACP00000014679	Aquarius intron-binding spliceosomal factor.	Elongation factor Tu GTP binding domain containing 2.	0.998