(90 nodes) Mixed, incl. Cellular amino acid biosynthetic process, and One-carbon metabolic process network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TMEM109	Uncharacterized protein. (257 aa)
	GCAT	Glycine C-acetyltransferase. (311 aa)
	MTHFD2L	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like. (322 aa)
	GLUL	Glutamine synthetase. (408 aa)
	H2ZWH9_LATCH	Uncharacterized protein. (219 aa)
	DAO	D-amino acid oxidase. (347 aa)
	LOC102358398	CN hydrolase domain-containing protein. (451 aa)
	SRR	Serine racemase. (337 aa)
	LOC102360660	Aminotran_5 domain-containing protein. (368 aa)
	LOC102346076	Aminotran_5 domain-containing protein. (349 aa)
	IBA57	Iron-sulfur cluster assembly factor IBA57. (314 aa)
	THNSL1	Threonine synthase like 1. (746 aa)
	SARDH	Sarcosine dehydrogenase. (876 aa)
	BCAT2	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (417 aa)
	CTH	Uncharacterized protein. (410 aa)
	SDSL	Serine dehydratase like. (325 aa)
	BTD	Biotinidase. (394 aa)
	LGSN	Lengsin, lens protein with glutamine synthetase domain; Belongs to the glutamine synthetase family. (451 aa)
	LOC102361022	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (391 aa)
	AGXT2	Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (516 aa)
	ALDH1L2	10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (924 aa)
	H3A556_LATCH	THF_DHG_CYH domain-containing protein. (63 aa)
	ALDH5A1	Succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (511 aa)
	LOC102345272	Phosphoserine aminotransferase. (368 aa)
	LOC102358421	Uncharacterized protein. (548 aa)
	MAT2A	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (391 aa)
	GCSH	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (177 aa)
	MTHFD1L	Uncharacterized protein. (90 aa)
	AASS	Aminoadipate-semialdehyde synthase. (935 aa)
	ABAT	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (490 aa)
	LOC102363271	5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (213 aa)
	AGXT	Serine--pyruvate aminotransferase. (426 aa)
	GLUD1	Glutamate dehydrogenase 1b; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (541 aa)
	DHFR	Dihydrofolate reductase. (206 aa)
	CBS	Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (563 aa)
	LOC102346348	Zgc:153031; Belongs to the dihydrofolate reductase family. (198 aa)
	LOC102353169	Uncharacterized protein. (245 aa)
	CPS1	Carbamoyl-phosphate synthase 1. (1332 aa)
	PIPOX	Pipecolic acid and sarcosine oxidase. (394 aa)
	GNMT	Glycine N-methyltransferase. (295 aa)
	ACY1	Aminoacylase 1. (428 aa)
	GLDC	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (914 aa)
	MTHFR	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (650 aa)
	SHMT1	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (474 aa)
	AADACL4	Arylacetamide deacetylase-like 4. (421 aa)
	MAT2B	Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. (341 aa)
	LOC102347529	Zgc:172121. (301 aa)
	MTHFD2	Uncharacterized protein. (338 aa)
	LOC102354530	Aminotran_1_2 domain-containing protein. (422 aa)
	ALDH18A1	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. (796 aa)
	FDXR	NADPH:adrenodoxin oxidoreductase, mitochondrial. (485 aa)
	CAD	Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. (2203 aa)
	FTCD	Formimidoyltransferase cyclodeaminase. (547 aa)
	GAD1	Glutamate decarboxylase 1. (590 aa)
	ASNSD1	Asparagine synthetase domain containing 1. (642 aa)
	PHGDH	Phosphoglycerate dehydrogenase. (522 aa)
	ALAS2	5-aminolevulinate synthase. (615 aa)
	FAAH2	Fatty acid amide hydrolase 2. (534 aa)
	PHYKPL	5-phosphohydroxy-L-lysine phospho-lyase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (462 aa)
	OTC	Ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (354 aa)
	LOC102361837	Glutamine synthetase. (370 aa)
	AMT	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (422 aa)
	OAT	Ornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (443 aa)
	TYMS	Thymidylate synthetase. (309 aa)
	GLS	Glutaminase. (577 aa)
	MTR	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1252 aa)
	MTHFD1	Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1. (930 aa)
	MTFMT	Mitochondrial methionyl-tRNA formyltransferase. (402 aa)
	BCAT1	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (385 aa)
	FPGS	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (595 aa)
	CNDP2	Carnosine dipeptidase 2. (474 aa)
	LOC102355447	Zgc:114181. (490 aa)
	LOC102346865	Threonine aldolase 1. (417 aa)
	LOC102354684	Immunoresponsive gene 1, like. (506 aa)
	ASS1	Argininosuccinate synthase 1. (441 aa)
	ARG2	Arginase. (363 aa)
	LOC102348032	Zgc:153901. (333 aa)
	LOC102351553	Betaine-homocysteine methyltransferase; Involved in the regulation of homocysteine metabolism. (276 aa)
	DMGDH	Dimethylglycine dehydrogenase. (750 aa)
	HDC	Histidine decarboxylase. (666 aa)
	ALAS1	5-aminolevulinate synthase. (642 aa)
	GLS2	Glutaminase 2. (601 aa)
	AHCY	Adenosylhomocysteinase; Belongs to the adenosylhomocysteinase family. (507 aa)
	SHMT2	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (542 aa)
	IAH1	Isoamyl acetate hydrolyzing esterase 1 (putative). (164 aa)
	AHCYL1	Adenosylhomocysteinase like 1; Belongs to the adenosylhomocysteinase family. (521 aa)
	AHCYL2	Adenosylhomocysteinase like 2; Belongs to the adenosylhomocysteinase family. (525 aa)
	GART	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (1031 aa)
	PSPH	Phosphoserine phosphatase. (248 aa)
	ERICH2	Glutamate rich 2. (143 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AADACL4	ABAT	ENSLACP00000011292	ENSLACP00000006938	Arylacetamide deacetylase-like 4.	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.709
AADACL4	AGXT	ENSLACP00000011292	ENSLACP00000007350	Arylacetamide deacetylase-like 4.	Serine--pyruvate aminotransferase.	0.452
AADACL4	ALDH5A1	ENSLACP00000011292	ENSLACP00000004782	Arylacetamide deacetylase-like 4.	Succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.702
AASS	AGXT	ENSLACP00000006766	ENSLACP00000007350	Aminoadipate-semialdehyde synthase.	Serine--pyruvate aminotransferase.	0.432
AASS	ALDH18A1	ENSLACP00000006766	ENSLACP00000012633	Aminoadipate-semialdehyde synthase.	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.	0.704
AASS	ALDH1L2	ENSLACP00000006766	ENSLACP00000004726	Aminoadipate-semialdehyde synthase.	10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.	0.505
AASS	AMT	ENSLACP00000006766	ENSLACP00000017424	Aminoadipate-semialdehyde synthase.	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	0.688
AASS	ASS1	ENSLACP00000006766	ENSLACP00000020235	Aminoadipate-semialdehyde synthase.	Argininosuccinate synthase 1.	0.720
AASS	GLDC	ENSLACP00000006766	ENSLACP00000010100	Aminoadipate-semialdehyde synthase.	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.	0.504
AASS	GLS	ENSLACP00000006766	ENSLACP00000018602	Aminoadipate-semialdehyde synthase.	Glutaminase.	0.511
AASS	GLS2	ENSLACP00000006766	ENSLACP00000021640	Aminoadipate-semialdehyde synthase.	Glutaminase 2.	0.511
AASS	GLUD1	ENSLACP00000006766	ENSLACP00000007586	Aminoadipate-semialdehyde synthase.	Glutamate dehydrogenase 1b; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	0.617
AASS	LOC102346865	ENSLACP00000006766	ENSLACP00000019944	Aminoadipate-semialdehyde synthase.	Threonine aldolase 1.	0.552
AASS	LOC102358398	ENSLACP00000006766	ENSLACP00000001881	Aminoadipate-semialdehyde synthase.	CN hydrolase domain-containing protein.	0.821
AASS	LOC102361022	ENSLACP00000006766	ENSLACP00000004110	Aminoadipate-semialdehyde synthase.	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	0.403
AASS	MAT2A	ENSLACP00000006766	ENSLACP00000005914	Aminoadipate-semialdehyde synthase.	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	0.403
AASS	OAT	ENSLACP00000006766	ENSLACP00000017508	Aminoadipate-semialdehyde synthase.	Ornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.735
AASS	OTC	ENSLACP00000006766	ENSLACP00000017385	Aminoadipate-semialdehyde synthase.	Ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily.	0.493
AASS	PHGDH	ENSLACP00000006766	ENSLACP00000015657	Aminoadipate-semialdehyde synthase.	Phosphoglycerate dehydrogenase.	0.623
AASS	PHYKPL	ENSLACP00000006766	ENSLACP00000017347	Aminoadipate-semialdehyde synthase.	5-phosphohydroxy-L-lysine phospho-lyase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.933