(57 nodes) Glycine, serine and threonine metabolism, and One-carbon metabolic process network (Latimeria chalumnae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

Your Input:
	GCAT	Glycine C-acetyltransferase. (311 aa)
	MTHFD2L	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like. (322 aa)
	H2ZWH9_LATCH	Uncharacterized protein. (219 aa)
	DAO	D-amino acid oxidase. (347 aa)
	SRR	Serine racemase. (337 aa)
	LOC102360660	Aminotran_5 domain-containing protein. (368 aa)
	LOC102346076	Aminotran_5 domain-containing protein. (349 aa)
	IBA57	Iron-sulfur cluster assembly factor IBA57. (314 aa)
	THNSL1	Threonine synthase like 1. (746 aa)
	SARDH	Sarcosine dehydrogenase. (876 aa)
	BCAT2	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (417 aa)
	CTH	Uncharacterized protein. (410 aa)
	SDSL	Serine dehydratase like. (325 aa)
	LOC102361022	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (391 aa)
	AGXT2	Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (516 aa)
	ALDH1L2	10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (924 aa)
	H3A556_LATCH	THF_DHG_CYH domain-containing protein. (63 aa)
	LOC102345272	Phosphoserine aminotransferase. (368 aa)
	MAT2A	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (391 aa)
	GCSH	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (177 aa)
	MTHFD1L	Uncharacterized protein. (90 aa)
	LOC102363271	5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (213 aa)
	AGXT	Serine--pyruvate aminotransferase. (426 aa)
	DHFR	Dihydrofolate reductase. (206 aa)
	CBS	Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (563 aa)
	LOC102346348	Zgc:153031; Belongs to the dihydrofolate reductase family. (198 aa)
	LOC102353169	Uncharacterized protein. (245 aa)
	PIPOX	Pipecolic acid and sarcosine oxidase. (394 aa)
	GNMT	Glycine N-methyltransferase. (295 aa)
	GLDC	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (914 aa)
	MTHFR	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (650 aa)
	SHMT1	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (474 aa)
	MAT2B	Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. (341 aa)
	LOC102347529	Zgc:172121. (301 aa)
	MTHFD2	Uncharacterized protein. (338 aa)
	FTCD	Formimidoyltransferase cyclodeaminase. (547 aa)
	PHGDH	Phosphoglycerate dehydrogenase. (522 aa)
	ALAS2	5-aminolevulinate synthase. (615 aa)
	AMT	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (422 aa)
	TYMS	Thymidylate synthetase. (309 aa)
	MTR	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1252 aa)
	MTHFD1	Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1. (930 aa)
	MTFMT	Mitochondrial methionyl-tRNA formyltransferase. (402 aa)
	BCAT1	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (385 aa)
	FPGS	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (595 aa)
	LOC102346865	Threonine aldolase 1. (417 aa)
	LOC102354684	Immunoresponsive gene 1, like. (506 aa)
	LOC102348032	Zgc:153901. (333 aa)
	LOC102351553	Betaine-homocysteine methyltransferase; Involved in the regulation of homocysteine metabolism. (276 aa)
	DMGDH	Dimethylglycine dehydrogenase. (750 aa)
	ALAS1	5-aminolevulinate synthase. (642 aa)
	AHCY	Adenosylhomocysteinase; Belongs to the adenosylhomocysteinase family. (507 aa)
	SHMT2	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (542 aa)
	AHCYL1	Adenosylhomocysteinase like 1; Belongs to the adenosylhomocysteinase family. (521 aa)
	AHCYL2	Adenosylhomocysteinase like 2; Belongs to the adenosylhomocysteinase family. (525 aa)
	GART	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (1031 aa)
	PSPH	Phosphoserine phosphatase. (248 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGXT	AGXT2	ENSLACP00000007350	ENSLACP00000004295	Serine--pyruvate aminotransferase.	Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.981
AGXT	ALAS1	ENSLACP00000007350	ENSLACP00000021401	Serine--pyruvate aminotransferase.	5-aminolevulinate synthase.	0.924
AGXT	ALAS2	ENSLACP00000007350	ENSLACP00000016314	Serine--pyruvate aminotransferase.	5-aminolevulinate synthase.	0.924
AGXT	ALDH1L2	ENSLACP00000007350	ENSLACP00000004726	Serine--pyruvate aminotransferase.	10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.	0.498
AGXT	AMT	ENSLACP00000007350	ENSLACP00000017424	Serine--pyruvate aminotransferase.	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	0.979
AGXT	BCAT1	ENSLACP00000007350	ENSLACP00000019159	Serine--pyruvate aminotransferase.	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	0.428
AGXT	BCAT2	ENSLACP00000007350	ENSLACP00000002299	Serine--pyruvate aminotransferase.	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	0.428
AGXT	CBS	ENSLACP00000007350	ENSLACP00000007861	Serine--pyruvate aminotransferase.	Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family.	0.950
AGXT	DAO	ENSLACP00000007350	ENSLACP00000001851	Serine--pyruvate aminotransferase.	D-amino acid oxidase.	0.981
AGXT	DMGDH	ENSLACP00000007350	ENSLACP00000020572	Serine--pyruvate aminotransferase.	Dimethylglycine dehydrogenase.	0.595
AGXT	FTCD	ENSLACP00000007350	ENSLACP00000014032	Serine--pyruvate aminotransferase.	Formimidoyltransferase cyclodeaminase.	0.720
AGXT	GART	ENSLACP00000007350	ENSLACP00000022410	Serine--pyruvate aminotransferase.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.859
AGXT	GCAT	ENSLACP00000007350	ENSLACP00000000288	Serine--pyruvate aminotransferase.	Glycine C-acetyltransferase.	0.943
AGXT	GCSH	ENSLACP00000007350	ENSLACP00000006340	Serine--pyruvate aminotransferase.	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	0.969
AGXT	GLDC	ENSLACP00000007350	ENSLACP00000010100	Serine--pyruvate aminotransferase.	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.	0.973
AGXT	GNMT	ENSLACP00000007350	ENSLACP00000009830	Serine--pyruvate aminotransferase.	Glycine N-methyltransferase.	0.921
AGXT	H2ZWH9_LATCH	ENSLACP00000007350	ENSLACP00000001750	Serine--pyruvate aminotransferase.	Uncharacterized protein.	0.577
AGXT	LOC102345272	ENSLACP00000007350	ENSLACP00000005032	Serine--pyruvate aminotransferase.	Phosphoserine aminotransferase.	0.446
AGXT	LOC102346076	ENSLACP00000007350	ENSLACP00000002048	Serine--pyruvate aminotransferase.	Aminotran_5 domain-containing protein.	0.446
AGXT	LOC102346865	ENSLACP00000007350	ENSLACP00000019944	Serine--pyruvate aminotransferase.	Threonine aldolase 1.	0.996