STRINGSTRING
MTHFD2L MTHFD2L H2ZWH9_LATCH H2ZWH9_LATCH IBA57 IBA57 CTH CTH LOC102361022 LOC102361022 ALDH1L2 ALDH1L2 H3A556_LATCH H3A556_LATCH MAT2A MAT2A GCSH GCSH MTHFD1L MTHFD1L LOC102363271 LOC102363271 DHFR DHFR CBS CBS LOC102346348 LOC102346348 LOC102353169 LOC102353169 GLDC GLDC MTHFR MTHFR SHMT1 SHMT1 MAT2B MAT2B LOC102347529 LOC102347529 MTHFD2 MTHFD2 FTCD FTCD AMT AMT TYMS TYMS MTR MTR MTHFD1 MTHFD1 MTFMT MTFMT FPGS FPGS LOC102354684 LOC102354684 LOC102348032 LOC102348032 LOC102351553 LOC102351553 DMGDH DMGDH AHCY AHCY SHMT2 SHMT2 AHCYL1 AHCYL1 AHCYL2 AHCYL2 GART GART
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MTHFD2LMethylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like. (322 aa)
H2ZWH9_LATCHUncharacterized protein. (219 aa)
IBA57Iron-sulfur cluster assembly factor IBA57. (314 aa)
CTHUncharacterized protein. (410 aa)
LOC102361022S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (391 aa)
ALDH1L210-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (924 aa)
H3A556_LATCHTHF_DHG_CYH domain-containing protein. (63 aa)
MAT2AS-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (391 aa)
GCSHGlycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (177 aa)
MTHFD1LUncharacterized protein. (90 aa)
LOC1023632715-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (213 aa)
DHFRDihydrofolate reductase. (206 aa)
CBSCystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (563 aa)
LOC102346348Zgc:153031; Belongs to the dihydrofolate reductase family. (198 aa)
LOC102353169Uncharacterized protein. (245 aa)
GLDCGlycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (914 aa)
MTHFRMethylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (650 aa)
SHMT1Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (474 aa)
MAT2BMethionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. (341 aa)
LOC102347529Zgc:172121. (301 aa)
MTHFD2Uncharacterized protein. (338 aa)
FTCDFormimidoyltransferase cyclodeaminase. (547 aa)
AMTAminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (422 aa)
TYMSThymidylate synthetase. (309 aa)
MTRMethionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1252 aa)
MTHFD1Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1. (930 aa)
MTFMTMitochondrial methionyl-tRNA formyltransferase. (402 aa)
FPGSFolylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (595 aa)
LOC102354684Immunoresponsive gene 1, like. (506 aa)
LOC102348032Zgc:153901. (333 aa)
LOC102351553Betaine-homocysteine methyltransferase; Involved in the regulation of homocysteine metabolism. (276 aa)
DMGDHDimethylglycine dehydrogenase. (750 aa)
AHCYAdenosylhomocysteinase; Belongs to the adenosylhomocysteinase family. (507 aa)
SHMT2Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (542 aa)
AHCYL1Adenosylhomocysteinase like 1; Belongs to the adenosylhomocysteinase family. (521 aa)
AHCYL2Adenosylhomocysteinase like 2; Belongs to the adenosylhomocysteinase family. (525 aa)
GARTTrifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (1031 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.