(11 nodes) Mixed, incl. DNA recombinase complex, and Protein adenylylation network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PTCHD1	Patched domain containing 1. (902 aa)
	GPR85	G protein-coupled receptor 85. (370 aa)
	SACS	Sacsin molecular chaperone. (4576 aa)
	RAG1	V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1045 aa)
	RAG2	Recombination activating 2. (522 aa)
	PLAGL2	PLAG1 like zinc finger 2. (507 aa)
	SVEP1	Sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1. (3259 aa)
	ENC1	Ectodermal-neural cortex 1. (591 aa)
	FICD	FIC domain containing. (458 aa)
	NWD2	NACHT and WD repeat domain containing 2. (1643 aa)
	RIPK4	Receptor interacting serine/threonine kinase 4. (566 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENC1	FICD	ENSLACP00000008649	ENSLACP00000009031	Ectodermal-neural cortex 1.	FIC domain containing.	0.543
ENC1	GPR85	ENSLACP00000008649	ENSLACP00000003878	Ectodermal-neural cortex 1.	G protein-coupled receptor 85.	0.439
ENC1	NWD2	ENSLACP00000008649	ENSLACP00000012043	Ectodermal-neural cortex 1.	NACHT and WD repeat domain containing 2.	0.545
ENC1	PLAGL2	ENSLACP00000008649	ENSLACP00000007312	Ectodermal-neural cortex 1.	PLAG1 like zinc finger 2.	0.773
ENC1	PTCHD1	ENSLACP00000008649	ENSLACP00000001332	Ectodermal-neural cortex 1.	Patched domain containing 1.	0.644
ENC1	RAG1	ENSLACP00000008649	ENSLACP00000004955	Ectodermal-neural cortex 1.	V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...]	0.747
ENC1	RIPK4	ENSLACP00000008649	ENSLACP00000018007	Ectodermal-neural cortex 1.	Receptor interacting serine/threonine kinase 4.	0.660
ENC1	SVEP1	ENSLACP00000008649	ENSLACP00000007544	Ectodermal-neural cortex 1.	Sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1.	0.401
FICD	ENC1	ENSLACP00000009031	ENSLACP00000008649	FIC domain containing.	Ectodermal-neural cortex 1.	0.543
FICD	GPR85	ENSLACP00000009031	ENSLACP00000003878	FIC domain containing.	G protein-coupled receptor 85.	0.755
FICD	NWD2	ENSLACP00000009031	ENSLACP00000012043	FIC domain containing.	NACHT and WD repeat domain containing 2.	0.638
FICD	PLAGL2	ENSLACP00000009031	ENSLACP00000007312	FIC domain containing.	PLAG1 like zinc finger 2.	0.679
FICD	PTCHD1	ENSLACP00000009031	ENSLACP00000001332	FIC domain containing.	Patched domain containing 1.	0.746
FICD	RAG1	ENSLACP00000009031	ENSLACP00000004955	FIC domain containing.	V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...]	0.611
FICD	RAG2	ENSLACP00000009031	ENSLACP00000005300	FIC domain containing.	Recombination activating 2.	0.635
FICD	RIPK4	ENSLACP00000009031	ENSLACP00000018007	FIC domain containing.	Receptor interacting serine/threonine kinase 4.	0.709
GPR85	ENC1	ENSLACP00000003878	ENSLACP00000008649	G protein-coupled receptor 85.	Ectodermal-neural cortex 1.	0.439
GPR85	FICD	ENSLACP00000003878	ENSLACP00000009031	G protein-coupled receptor 85.	FIC domain containing.	0.755
GPR85	NWD2	ENSLACP00000003878	ENSLACP00000012043	G protein-coupled receptor 85.	NACHT and WD repeat domain containing 2.	0.545
GPR85	PLAGL2	ENSLACP00000003878	ENSLACP00000007312	G protein-coupled receptor 85.	PLAG1 like zinc finger 2.	0.582