(20 nodes) Branching involved in ureteric bud morphogenesis network (Latimeria chalumnae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

gene neighborhood

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Your Input:
	CTNNB1	Catenin beta 1. (781 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (373 aa)
	LOC102350297	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	LOC102358988	Mothers against decapentaplegic homolog. (614 aa)
	WT1	WT1 transcription factor. (422 aa)
	WNT6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (348 aa)
	PTCH1	Patched 1. (1287 aa)
	GLI3	GLI family zinc finger 3. (1456 aa)
	PKD2	Polycystin 2, transient receptor potential cation channel. (890 aa)
	TCF21	Transcription factor 21. (179 aa)
	GREB1	Uncharacterized protein. (1948 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	GREB1L	GREB1 like retinoic acid receptor coactivator. (1842 aa)
	SMAD4	MH2 domain-containing protein. (412 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	TMEM59L	Transmembrane protein 59 like. (340 aa)
	CTNNBIP1	Catenin beta interacting protein 1. (81 aa)
	GDNF	Glial cell derived neurotrophic factor. (222 aa)
	ILK	Integrin linked kinase. (417 aa)
	WNT9B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTNNB1	CTNNBIP1	ENSLACP00000017209	ENSLACP00000007182	Catenin beta 1.	Catenin beta interacting protein 1.	0.999
CTNNB1	FGF8	ENSLACP00000017209	ENSLACP00000007843	Catenin beta 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.437
CTNNB1	ILK	ENSLACP00000017209	ENSLACP00000006792	Catenin beta 1.	Integrin linked kinase.	0.458
CTNNB1	LOC102350297	ENSLACP00000017209	ENSLACP00000021630	Catenin beta 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.473
CTNNB1	LOC102358988	ENSLACP00000017209	ENSLACP00000022115	Catenin beta 1.	Mothers against decapentaplegic homolog.	0.627
CTNNB1	SMAD4	ENSLACP00000017209	ENSLACP00000009312	Catenin beta 1.	MH2 domain-containing protein.	0.627
CTNNB1	WNT1	ENSLACP00000017209	ENSLACP00000021628	Catenin beta 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.840
CTNNB1	WNT6	ENSLACP00000017209	ENSLACP00000019459	Catenin beta 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.473
CTNNB1	WNT9B	ENSLACP00000017209	ENSLACP00000006321	Catenin beta 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.436
CTNNBIP1	CTNNB1	ENSLACP00000007182	ENSLACP00000017209	Catenin beta interacting protein 1.	Catenin beta 1.	0.999
FGF1	FGF8	ENSLACP00000015106	ENSLACP00000007843	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.581
FGF1	GLI3	ENSLACP00000015106	ENSLACP00000004224	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	GLI family zinc finger 3.	0.462
FGF8	CTNNB1	ENSLACP00000007843	ENSLACP00000017209	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Catenin beta 1.	0.437
FGF8	FGF1	ENSLACP00000007843	ENSLACP00000015106	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.581
FGF8	GDNF	ENSLACP00000007843	ENSLACP00000007058	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Glial cell derived neurotrophic factor.	0.578
FGF8	GLI3	ENSLACP00000007843	ENSLACP00000004224	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	GLI family zinc finger 3.	0.634
FGF8	PTCH1	ENSLACP00000007843	ENSLACP00000004070	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Patched 1.	0.554
FGF8	WNT1	ENSLACP00000007843	ENSLACP00000021628	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.716
GDNF	FGF8	ENSLACP00000007058	ENSLACP00000007843	Glial cell derived neurotrophic factor.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.578
GLI3	FGF1	ENSLACP00000004224	ENSLACP00000015106	GLI family zinc finger 3.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.462