(57 nodes) Cell fate specification network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TBX5	T-box transcription factor 5. (522 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (820 aa)
	MGA	MAX dimerization protein MGA. (2907 aa)
	EOMES	Eomesodermin. (419 aa)
	PTCH1	Patched 1. (1287 aa)
	GLI3	GLI family zinc finger 3. (1456 aa)
	TBR1	T-box brain transcription factor 1. (673 aa)
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
	TBX6	Uncharacterized protein. (101 aa)
	LOC102357940	Uncharacterized protein. (440 aa)
	SOX18	SRY-box transcription factor 18. (427 aa)
	PRDM14	PR/SET domain 14. (599 aa)
	APC	APC regulator of WNT signaling pathway. (2802 aa)
	GSC	Goosecoid homeobox. (243 aa)
	TBX3	T-box transcription factor 3. (713 aa)
	TBX22	T-box transcription factor 22. (509 aa)
	FKBP8	Peptidylprolyl isomerase. (443 aa)
	SFRP2	Secreted frizzled related protein 2. (294 aa)
	DLL3	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (699 aa)
	TBX15	T-box transcription factor 15. (566 aa)
	GSX2	GS homeobox 2. (279 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
	APC2	APC regulator of WNT signaling pathway 2. (2366 aa)
	TBX19	T-box transcription factor 19. (373 aa)
	SUFU	SUFU negative regulator of hedgehog signaling. (422 aa)
	HOXD10	Homeobox D10. (337 aa)
	TBX20	T-box transcription factor 20. (441 aa)
	LOC102355848	Uncharacterized protein. (306 aa)
	LOC102365298	Uncharacterized protein. (427 aa)
	ISL2	ISL LIM homeobox 2. (360 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (465 aa)
	DBX1	Developing brain homeobox 1. (326 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (421 aa)
	DMRT3	Doublesex and mab-3 related transcription factor 3. (484 aa)
	ISL1	ISL LIM homeobox 1. (356 aa)
	MNX1	Motor neuron and pancreas homeobox 1. (313 aa)
	LOC102345533	T-box transcription factor 16. (438 aa)
	H3B181_LATCH	Teneurin transmembrane protein 4. (1031 aa)
	FEV	FEV transcription factor, ETS family member. (230 aa)
	PTCH2	Patched 2. (1134 aa)
	TBX4	T-box transcription factor 4. (541 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	SOX17	SRY-box transcription factor 17. (381 aa)
	PAX6	Paired box 6. (463 aa)
	MYL2	Myosin light chain 2. (148 aa)
	TBX2	T-box transcription factor 2. (689 aa)
	TBXT	T-box transcription factor T. (434 aa)
	H3B6N2_LATCH	Teneurin N-terminal domain-containing protein. (214 aa)
	TBX18	T-box transcription factor 18. (568 aa)
	H3B938_LATCH	Teneurin N-terminal domain-containing protein. (181 aa)
	TBX1	T-box transcription factor 1. (457 aa)
	HOXC10	Homeobox C10. (339 aa)
	TBX21	T-box transcription factor 21. (570 aa)
	HOXA13	Homeobox A13b. (295 aa)
	HNF1A	HNF1 homeobox A. (624 aa)
	H3BF30_LATCH	Uncharacterized protein. (199 aa)
	DHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (424 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APC	CTNNB1	ENSLACP00000005734	ENSLACP00000017209	APC regulator of WNT signaling pathway.	Catenin beta 1.	0.963
APC2	CTNNB1	ENSLACP00000009395	ENSLACP00000017209	APC regulator of WNT signaling pathway 2.	Catenin beta 1.	0.963
CTNNB1	APC	ENSLACP00000017209	ENSLACP00000005734	Catenin beta 1.	APC regulator of WNT signaling pathway.	0.963
CTNNB1	APC2	ENSLACP00000017209	ENSLACP00000009395	Catenin beta 1.	APC regulator of WNT signaling pathway 2.	0.963
CTNNB1	EOMES	ENSLACP00000017209	ENSLACP00000003120	Catenin beta 1.	Eomesodermin.	0.544
CTNNB1	LOC102345533	ENSLACP00000017209	ENSLACP00000014635	Catenin beta 1.	T-box transcription factor 16.	0.471
CTNNB1	PSEN1	ENSLACP00000017209	ENSLACP00000012775	Catenin beta 1.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.888
CTNNB1	SFRP2	ENSLACP00000017209	ENSLACP00000007301	Catenin beta 1.	Secreted frizzled related protein 2.	0.568
CTNNB1	SMO	ENSLACP00000017209	ENSLACP00000002758	Catenin beta 1.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.483
CTNNB1	SOX17	ENSLACP00000017209	ENSLACP00000017352	Catenin beta 1.	SRY-box transcription factor 17.	0.700
CTNNB1	SOX18	ENSLACP00000017209	ENSLACP00000005708	Catenin beta 1.	SRY-box transcription factor 18.	0.700
CTNNB1	SUFU	ENSLACP00000017209	ENSLACP00000010491	Catenin beta 1.	SUFU negative regulator of hedgehog signaling.	0.454
CTNNB1	TBR1	ENSLACP00000017209	ENSLACP00000004379	Catenin beta 1.	T-box brain transcription factor 1.	0.436
CTNNB1	TBX4	ENSLACP00000017209	ENSLACP00000016704	Catenin beta 1.	T-box transcription factor 4.	0.480
CTNNB1	TBX5	ENSLACP00000017209	ENSLACP00000002614	Catenin beta 1.	T-box transcription factor 5.	0.480
DBX1	ISL2	ENSLACP00000012830	ENSLACP00000012674	Developing brain homeobox 1.	ISL LIM homeobox 2.	0.429
DHH	IHH	ENSLACP00000021608	ENSLACP00000004851	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.904
DHH	PTCH1	ENSLACP00000021608	ENSLACP00000004070	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Patched 1.	0.992
DHH	PTCH2	ENSLACP00000021608	ENSLACP00000016238	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Patched 2.	0.841
DHH	SHH	ENSLACP00000021608	ENSLACP00000013019	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.903