(9 nodes) Cytokine production network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	H2ZS97_LATCH	TNF_2 domain-containing protein. (143 aa)
	ITGB6	Integrin beta; Belongs to the integrin beta chain family. (675 aa)
	ITGAV	Integrin_alpha2 domain-containing protein. (597 aa)
	H3AES2_LATCH	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (354 aa)
	H3AEV1_LATCH	TNF_2 domain-containing protein. (230 aa)
	NRROS	Negative regulator of reactive oxygen species. (691 aa)
	IL6	Uncharacterized protein. (149 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (766 aa)
	IL6R	Interleukin 6 receptor. (469 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
H2ZS97_LATCH	IL6	ENSLACP00000000268	ENSLACP00000009318	TNF_2 domain-containing protein.	Uncharacterized protein.	0.470
H3AEV1_LATCH	IL6	ENSLACP00000008172	ENSLACP00000009318	TNF_2 domain-containing protein.	Uncharacterized protein.	0.470
IL6	H2ZS97_LATCH	ENSLACP00000009318	ENSLACP00000000268	Uncharacterized protein.	TNF_2 domain-containing protein.	0.470
IL6	H3AEV1_LATCH	ENSLACP00000009318	ENSLACP00000008172	Uncharacterized protein.	TNF_2 domain-containing protein.	0.470
IL6	IL6R	ENSLACP00000009318	ENSLACP00000022612	Uncharacterized protein.	Interleukin 6 receptor.	0.999
IL6	TLR3	ENSLACP00000009318	ENSLACP00000012956	Uncharacterized protein.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.674
IL6R	IL6	ENSLACP00000022612	ENSLACP00000009318	Interleukin 6 receptor.	Uncharacterized protein.	0.999
ITGAV	ITGB6	ENSLACP00000000513	ENSLACP00000000457	Integrin_alpha2 domain-containing protein.	Integrin beta; Belongs to the integrin beta chain family.	0.999
ITGB6	ITGAV	ENSLACP00000000457	ENSLACP00000000513	Integrin beta; Belongs to the integrin beta chain family.	Integrin_alpha2 domain-containing protein.	0.999
TLR3	IL6	ENSLACP00000012956	ENSLACP00000009318	Toll like receptor 3; Belongs to the Toll-like receptor family.	Uncharacterized protein.	0.674