(43 nodes) Epithelial to mesenchymal transition network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EOMES	Eomesodermin. (419 aa)
	MSX1	Msh homeobox 1. (256 aa)
	DLG5	Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1821 aa)
	LEF1	Lymphoid enhancer binding factor 1. (397 aa)
	GSC	Goosecoid homeobox. (243 aa)
	SNAI2	Snail family zinc finger 2. (268 aa)
	EDNRA	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (424 aa)
	TASOR	Transcription activation suppressor. (1626 aa)
	TGFBR3	Transforming growth factor beta receptor 3. (808 aa)
	DDX17	Uncharacterized protein; Belongs to the DEAD box helicase family. (699 aa)
	FGFR2	Fibroblast growth factor receptor. (810 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	TGFBR1	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
	PDCD6	Programmed cell death 6. (121 aa)
	WNT16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
	SMAD4	MH2 domain-containing protein. (412 aa)
	POLR1B	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1135 aa)
	LOXL4	Lysyl oxidase like 4. (765 aa)
	EFNA1	Ephrin A1; Belongs to the ephrin family. (176 aa)
	KBTBD8	Kelch repeat and BTB domain containing 8. (601 aa)
	TMEM100	Transmembrane protein 100. (134 aa)
	PEF1	Penta-EF-hand domain containing 1. (263 aa)
	KLHL12	Kelch like family member 12. (564 aa)
	LOXL2	Lysyl oxidase like 2. (773 aa)
	H3AVL9_LATCH	Lysyl oxidase-like 3b. (475 aa)
	FGFR1	Fibroblast growth factor receptor. (824 aa)
	ROCK1	Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1350 aa)
	EPB41L5	Erythrocyte membrane protein band 4.1 like 5. (506 aa)
	NOLC1	Nucleolar and coiled-body phosphoprotein 1. (954 aa)
	H3B4Z7_LATCH	Uncharacterized protein; Belongs to the cullin family. (1385 aa)
	DDX5	DEAD-box helicase 5; Belongs to the DEAD box helicase family. (512 aa)
	FAM83D	Family with sequence similarity 83 member D. (587 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
	EDN1	Endothelin 1. (216 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	LOC102352268	Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
	SNAI1	Snail family transcriptional repressor 1. (257 aa)
	WNT2B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
	LRP6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1615 aa)
	LOC102358988	Mothers against decapentaplegic homolog. (614 aa)
	ENG	Endoglin. (674 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DDX17	DDX5	ENSLACP00000007440	ENSLACP00000017080	Uncharacterized protein; Belongs to the DEAD box helicase family.	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	0.920
DDX17	NOLC1	ENSLACP00000007440	ENSLACP00000016958	Uncharacterized protein; Belongs to the DEAD box helicase family.	Nucleolar and coiled-body phosphoprotein 1.	0.415
DDX17	POLR1B	ENSLACP00000007440	ENSLACP00000010768	Uncharacterized protein; Belongs to the DEAD box helicase family.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.668
DDX5	DDX17	ENSLACP00000017080	ENSLACP00000007440	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Uncharacterized protein; Belongs to the DEAD box helicase family.	0.920
DDX5	NOLC1	ENSLACP00000017080	ENSLACP00000016958	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Nucleolar and coiled-body phosphoprotein 1.	0.441
DDX5	POLR1B	ENSLACP00000017080	ENSLACP00000010768	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.668
EDN1	EDNRA	ENSLACP00000018825	ENSLACP00000006100	Endothelin 1.	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	0.999
EDN1	FGF8	ENSLACP00000018825	ENSLACP00000007843	Endothelin 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.633
EDNRA	EDN1	ENSLACP00000006100	ENSLACP00000018825	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	Endothelin 1.	0.999
ENG	TGFB1	ENSLACP00000023030	ENSLACP00000020652	Endoglin.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.781
ENG	TGFBR1	ENSLACP00000023030	ENSLACP00000008197	Endoglin.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.786
EOMES	SNAI1	ENSLACP00000003120	ENSLACP00000020148	Eomesodermin.	Snail family transcriptional repressor 1.	0.471
EOMES	SNAI2	ENSLACP00000003120	ENSLACP00000006099	Eomesodermin.	Snail family zinc finger 2.	0.471
FGF2	FGFR1	ENSLACP00000019200	ENSLACP00000015392	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.870
FGF2	FGFR2	ENSLACP00000019200	ENSLACP00000007448	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.915
FGF2	TGFB1	ENSLACP00000019200	ENSLACP00000020652	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.577
FGF8	EDN1	ENSLACP00000007843	ENSLACP00000018825	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Endothelin 1.	0.633
FGF8	FGFR1	ENSLACP00000007843	ENSLACP00000015392	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.939
FGF8	FGFR2	ENSLACP00000007843	ENSLACP00000007448	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.971
FGF8	LEF1	ENSLACP00000007843	ENSLACP00000005598	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Lymphoid enhancer binding factor 1.	0.486