(36 nodes) Endothelial cell development network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RAPGEF1	Rap guanine nucleotide exchange factor 1. (1217 aa)
	LOC102347948	Uncharacterized protein. (290 aa)
	MYADM	Myeloid associated differentiation marker. (314 aa)
	H3A5Z5_LATCH	Hyaluronan and proteoglycan link protein 2. (306 aa)
	EDNRA	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (424 aa)
	H3AA95_LATCH	FZ domain-containing protein. (361 aa)
	EZR	Ezrin. (591 aa)
	PDE2A	Phosphodiesterase. (705 aa)
	COL18A1	LAM_G_DOMAIN domain-containing protein. (1308 aa)
	LOC102358221	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (439 aa)
	LOC102350832	Zgc:77748. (293 aa)
	RAPGEF2	Rap guanine nucleotide exchange factor 2. (1514 aa)
	MARVELD2	MARVEL domain containing 2. (563 aa)
	RAP1B	RAP1B, member of RAS oncogene family. (184 aa)
	H3ATS1_LATCH	Uncharacterized protein. (1079 aa)
	TJP2	Tight junction protein 2a (zona occludens 2). (1241 aa)
	FASN	Fatty acid synthase. (2502 aa)
	EDNRB	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (440 aa)
	MET	MET proto-oncogene, receptor tyrosine kinase. (1385 aa)
	AFDN	Afadin, adherens junction formation factor. (1854 aa)
	TJP3	Tight junction protein 3; Belongs to the MAGUK family. (859 aa)
	CLIC4	Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (252 aa)
	MSN	Moesin. (583 aa)
	H3B5Z8_LATCH	Uncharacterized protein. (606 aa)
	LOC102354417	Uncharacterized protein. (723 aa)
	CLDN1	Claudin 1. (210 aa)
	ARHGEF26	Rho guanine nucleotide exchange factor 26. (899 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (286 aa)
	HOXA13	Homeobox A13b. (295 aa)
	RAP1A	RAP1A, member of RAS oncogene family b. (185 aa)
	TJP1	Tight junction protein 1; Belongs to the MAGUK family. (1782 aa)
	RAPGEF3	Ras-GEF domain-containing protein. (459 aa)
	LOC102365550	Uncharacterized protein. (218 aa)
	HPSE	Heparanase. (544 aa)
	UBIAD1	UbiA prenyltransferase domain containing 1. (368 aa)
	CCM2	CCM2 scaffold protein. (447 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFDN	LOC102347948	ENSLACP00000015429	ENSLACP00000001081	Afadin, adherens junction formation factor.	Uncharacterized protein.	0.969
AFDN	LOC102365550	ENSLACP00000015429	ENSLACP00000021954	Afadin, adherens junction formation factor.	Uncharacterized protein.	0.969
AFDN	MARVELD2	ENSLACP00000015429	ENSLACP00000012466	Afadin, adherens junction formation factor.	MARVEL domain containing 2.	0.443
AFDN	RAP1A	ENSLACP00000015429	ENSLACP00000021077	Afadin, adherens junction formation factor.	RAP1A, member of RAS oncogene family b.	0.960
AFDN	RAP1B	ENSLACP00000015429	ENSLACP00000012966	Afadin, adherens junction formation factor.	RAP1B, member of RAS oncogene family.	0.622
AFDN	RAPGEF2	ENSLACP00000015429	ENSLACP00000010647	Afadin, adherens junction formation factor.	Rap guanine nucleotide exchange factor 2.	0.487
AFDN	TJP1	ENSLACP00000015429	ENSLACP00000021216	Afadin, adherens junction formation factor.	Tight junction protein 1; Belongs to the MAGUK family.	0.982
AFDN	TJP2	ENSLACP00000015429	ENSLACP00000013056	Afadin, adherens junction formation factor.	Tight junction protein 2a (zona occludens 2).	0.981
AFDN	TJP3	ENSLACP00000015429	ENSLACP00000015979	Afadin, adherens junction formation factor.	Tight junction protein 3; Belongs to the MAGUK family.	0.749
CLDN1	LOC102347948	ENSLACP00000017569	ENSLACP00000001081	Claudin 1.	Uncharacterized protein.	0.476
CLDN1	LOC102365550	ENSLACP00000017569	ENSLACP00000021954	Claudin 1.	Uncharacterized protein.	0.476
CLDN1	MARVELD2	ENSLACP00000017569	ENSLACP00000012466	Claudin 1.	MARVEL domain containing 2.	0.553
CLDN1	MYD88	ENSLACP00000017569	ENSLACP00000019094	Claudin 1.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.428
CLDN1	TJP1	ENSLACP00000017569	ENSLACP00000021216	Claudin 1.	Tight junction protein 1; Belongs to the MAGUK family.	0.908
CLDN1	TJP2	ENSLACP00000017569	ENSLACP00000013056	Claudin 1.	Tight junction protein 2a (zona occludens 2).	0.729
CLDN1	TJP3	ENSLACP00000017569	ENSLACP00000015979	Claudin 1.	Tight junction protein 3; Belongs to the MAGUK family.	0.729
CLIC4	EZR	ENSLACP00000016536	ENSLACP00000006611	Chloride intracellular channel protein; Belongs to the chloride channel CLIC family.	Ezrin.	0.460
EDNRA	EDNRB	ENSLACP00000006100	ENSLACP00000014962	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family.	0.970
EDNRA	LOC102358221	ENSLACP00000006100	ENSLACP00000008101	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.969
EDNRB	EDNRA	ENSLACP00000014962	ENSLACP00000006100	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family.	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	0.970