(58 nodes) Liver development network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TST	Sulfurtransferase. (301 aa)
	CEBPG	CCAAT enhancer binding protein gamma. (150 aa)
	CPB2	Carboxypeptidase B2. (426 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (453 aa)
	ELK1	ETS transcription factor ELK1. (520 aa)
	FGL1	Fibrinogen like 1. (315 aa)
	H3AD77_LATCH	JunE proto-oncogene, AP-1 transcription factor subunit. (316 aa)
	RB1CC1	RB1-inducible coiled-coil 1. (1296 aa)
	CDK5RAP3	CDK5 regulatory subunit associated protein 3. (519 aa)
	JARID2	Jumonji and AT-rich interaction domain containing 2. (906 aa)
	IL6	Uncharacterized protein. (149 aa)
	LOC102354904	Uncharacterized protein. (648 aa)
	ACADM	Acyl-CoA dehydrogenase medium chain. (424 aa)
	HLX	H2.0 like homeobox. (384 aa)
	LOC102346566	Annexin. (343 aa)
	RHBDD3	Rhomboid domain containing 3. (379 aa)
	H3AM65_LATCH	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (472 aa)
	SMARCB1	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. (384 aa)
	H3AMM0_LATCH	ATG11 domain-containing protein. (241 aa)
	PCSK9	Proprotein convertase subtilisin/kexin type 9. (672 aa)
	SP3	Sp3 transcription factor. (785 aa)
	GFER	Sulfhydryl oxidase. (193 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1401 aa)
	LOC102351332	Zgc:158659; Belongs to the PI3/PI4-kinase family. (1067 aa)
	E2F7	Uncharacterized protein. (373 aa)
	H3B277_LATCH	Uncharacterized protein. (4290 aa)
	H3B2C8_LATCH	Uncharacterized protein. (389 aa)
	PTCD2	Pentatricopeptide repeat domain 2. (405 aa)
	SEC63	SEC63 homolog, protein translocation regulator. (763 aa)
	SLC7A5	Solute carrier family 7 member 5. (522 aa)
	CLDN1	Claudin 1. (210 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
	UPF2	UPF2 regulator of nonsense mediated mRNA decay. (1273 aa)
	E2F8	E2F transcription factor 8. (851 aa)
	H3BA30_LATCH	FHA domain-containing protein. (939 aa)
	PDX1	Pancreatic and duodenal homeobox 1. (257 aa)
	NF1	Neurofibromin 1. (2814 aa)
	CUL3	Cullin 3; Belongs to the cullin family. (769 aa)
	CCDC40	Coiled-coil domain containing 40. (859 aa)
	HNF1A	HNF1 homeobox A. (624 aa)
	TGFA	Transforming growth factor alpha. (140 aa)
	PCK1	Phosphoenolpyruvate carboxykinase 1. (622 aa)
	LOC102363355	ETS domain-containing protein. (380 aa)
	CIT	Citron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (2066 aa)
	H2ZSY2_LATCH	Uncharacterized protein. (345 aa)
	HGF	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (720 aa)
	RPGRIP1L	RPGRIP1 like. (1318 aa)
	GLI1	GLI family zinc finger 1. (1380 aa)
	LOC102349333	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (176 aa)
	CEBPB	CCAAT/enhancer-binding protein. (291 aa)
	DNAAF1	Dynein assembly factor 1, axonemal. (263 aa)
	GATA6	GATA binding protein 6. (503 aa)
	PTPN3	Tyrosine-protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (871 aa)
	PKD1	Polycystin 1, transient receptor potential channel interacting. (4241 aa)
	TAF10	Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (142 aa)
	PKD2	Polycystin 2, transient receptor potential cation channel. (890 aa)
	ARF6	ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
	JUN	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (311 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARF6	HGF	ENSLACP00000005263	ENSLACP00000023353	ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family.	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.521
ARF6	LOC102349333	ENSLACP00000005263	ENSLACP00000021262	ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family.	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.	0.900
CCDC40	DNAAF1	ENSLACP00000020296	ENSLACP00000002439	Coiled-coil domain containing 40.	Dynein assembly factor 1, axonemal.	0.571
CEBPB	CEBPG	ENSLACP00000002325	ENSLACP00000005727	CCAAT/enhancer-binding protein.	CCAAT enhancer binding protein gamma.	0.412
CEBPB	H3AD77_LATCH	ENSLACP00000002325	ENSLACP00000007598	CCAAT/enhancer-binding protein.	JunE proto-oncogene, AP-1 transcription factor subunit.	0.517
CEBPB	IL6	ENSLACP00000002325	ENSLACP00000009318	CCAAT/enhancer-binding protein.	Uncharacterized protein.	0.543
CEBPB	JUN	ENSLACP00000002325	ENSLACP00000005596	CCAAT/enhancer-binding protein.	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	0.618
CEBPG	CEBPB	ENSLACP00000005727	ENSLACP00000002325	CCAAT enhancer binding protein gamma.	CCAAT/enhancer-binding protein.	0.412
CEBPG	H3AD77_LATCH	ENSLACP00000005727	ENSLACP00000007598	CCAAT enhancer binding protein gamma.	JunE proto-oncogene, AP-1 transcription factor subunit.	0.412
CEBPG	JUN	ENSLACP00000005727	ENSLACP00000005596	CCAAT enhancer binding protein gamma.	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	0.412
CUL3	GLI1	ENSLACP00000019775	ENSLACP00000021691	Cullin 3; Belongs to the cullin family.	GLI family zinc finger 1.	0.626
CUL3	NF1	ENSLACP00000019775	ENSLACP00000019331	Cullin 3; Belongs to the cullin family.	Neurofibromin 1.	0.541
DNAAF1	CCDC40	ENSLACP00000002439	ENSLACP00000020296	Dynein assembly factor 1, axonemal.	Coiled-coil domain containing 40.	0.571
E2F7	E2F8	ENSLACP00000015934	ENSLACP00000018292	Uncharacterized protein.	E2F transcription factor 8.	0.556
E2F7	NF1	ENSLACP00000015934	ENSLACP00000019331	Uncharacterized protein.	Neurofibromin 1.	0.490
E2F8	E2F7	ENSLACP00000018292	ENSLACP00000015934	E2F transcription factor 8.	Uncharacterized protein.	0.556
E2F8	H2ZSY2_LATCH	ENSLACP00000018292	ENSLACP00000000503	E2F transcription factor 8.	Uncharacterized protein.	0.541
E2F8	NF1	ENSLACP00000018292	ENSLACP00000019331	E2F transcription factor 8.	Neurofibromin 1.	0.437
GATA6	NF1	ENSLACP00000002849	ENSLACP00000019331	GATA binding protein 6.	Neurofibromin 1.	0.401
GLI1	CUL3	ENSLACP00000021691	ENSLACP00000019775	GLI family zinc finger 1.	Cullin 3; Belongs to the cullin family.	0.626