(37 nodes) Heart looping network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DNAAF1	Dynein assembly factor 1, axonemal. (263 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (820 aa)
	H3A0S5_LATCH	Uncharacterized protein. (547 aa)
	ASB2	Ankyrin repeat and SOCS box containing 2. (658 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (585 aa)
	HAND2	Heart and neural crest derivatives expressed 2. (210 aa)
	PKD2	Polycystin 2, transient receptor potential cation channel. (890 aa)
	TBX6	Uncharacterized protein. (101 aa)
	TBX3	T-box transcription factor 3. (713 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	ARL13B	ADP ribosylation factor like GTPase 13B. (343 aa)
	MIB1	Mindbomb E3 ubiquitin protein ligase 1. (989 aa)
	CLUAP1	Clusterin associated protein 1. (348 aa)
	DLL3	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (699 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
	LOC102355487	Notochord homeobox. (242 aa)
	NOTO	Homeobox domain-containing protein. (234 aa)
	SUFU	SUFU negative regulator of hedgehog signaling. (422 aa)
	SETDB2	SET domain bifurcated histone lysine methyltransferase 2. (751 aa)
	H3APB2_LATCH	Fork-head domain-containing protein. (408 aa)
	STIL	STIL centriolar assembly protein. (1298 aa)
	TBX20	T-box transcription factor 20. (441 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (465 aa)
	MICAL2	Microtubule associated monooxygenase, calponin and LIM domain containing 2. (1131 aa)
	IFT57	Intraflagellar transport 57. (428 aa)
	ALCAM	Activated leukocyte cell adhesion molecule. (530 aa)
	LOC102345533	T-box transcription factor 16. (438 aa)
	CCDC103	Coiled-coil domain containing 103. (265 aa)
	SRF	Serum response factor. (520 aa)
	POPDC2	Popeye domain containing 2. (366 aa)
	NKX2-5	NK2 homeobox 5. (296 aa)
	TBX2	T-box transcription factor 2. (689 aa)
	TMED2	Transmembrane p24 trafficking protein 2. (208 aa)
	CCDC40	Coiled-coil domain containing 40. (859 aa)
	HAND1	Heart and neural crest derivatives expressed 1. (196 aa)
	IFT52	Intraflagellar transport 52. (440 aa)
	ENG	Endoglin. (674 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARL13B	H3A0S5_LATCH	ENSLACP00000008225	ENSLACP00000003246	ADP ribosylation factor like GTPase 13B.	Uncharacterized protein.	0.624
ARL13B	IFT52	ENSLACP00000008225	ENSLACP00000021626	ADP ribosylation factor like GTPase 13B.	Intraflagellar transport 52.	0.613
ARL13B	IFT57	ENSLACP00000008225	ENSLACP00000013629	ADP ribosylation factor like GTPase 13B.	Intraflagellar transport 57.	0.418
ARL13B	PKD2	ENSLACP00000008225	ENSLACP00000004922	ADP ribosylation factor like GTPase 13B.	Polycystin 2, transient receptor potential cation channel.	0.618
ARL13B	SMO	ENSLACP00000008225	ENSLACP00000002758	ADP ribosylation factor like GTPase 13B.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.623
ARL13B	SUFU	ENSLACP00000008225	ENSLACP00000010491	ADP ribosylation factor like GTPase 13B.	SUFU negative regulator of hedgehog signaling.	0.460
ASB2	IFT52	ENSLACP00000003534	ENSLACP00000021626	Ankyrin repeat and SOCS box containing 2.	Intraflagellar transport 52.	0.409
CCDC103	CCDC40	ENSLACP00000015091	ENSLACP00000020296	Coiled-coil domain containing 103.	Coiled-coil domain containing 40.	0.571
CCDC103	DNAAF1	ENSLACP00000015091	ENSLACP00000002439	Coiled-coil domain containing 103.	Dynein assembly factor 1, axonemal.	0.583
CCDC40	CCDC103	ENSLACP00000020296	ENSLACP00000015091	Coiled-coil domain containing 40.	Coiled-coil domain containing 103.	0.571
CCDC40	DNAAF1	ENSLACP00000020296	ENSLACP00000002439	Coiled-coil domain containing 40.	Dynein assembly factor 1, axonemal.	0.571
CLUAP1	IFT52	ENSLACP00000008605	ENSLACP00000021626	Clusterin associated protein 1.	Intraflagellar transport 52.	0.998
CLUAP1	IFT57	ENSLACP00000008605	ENSLACP00000013629	Clusterin associated protein 1.	Intraflagellar transport 57.	0.999
DLL1	DLL3	ENSLACP00000009351	ENSLACP00000008690	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.904
DLL1	MIB1	ENSLACP00000009351	ENSLACP00000008377	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Mindbomb E3 ubiquitin protein ligase 1.	0.426
DLL3	DLL1	ENSLACP00000008690	ENSLACP00000009351	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.904
DLL3	MIB1	ENSLACP00000008690	ENSLACP00000008377	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Mindbomb E3 ubiquitin protein ligase 1.	0.426
DNAAF1	CCDC103	ENSLACP00000002439	ENSLACP00000015091	Dynein assembly factor 1, axonemal.	Coiled-coil domain containing 103.	0.583
DNAAF1	CCDC40	ENSLACP00000002439	ENSLACP00000020296	Dynein assembly factor 1, axonemal.	Coiled-coil domain containing 40.	0.571
ENG	TGFBR2	ENSLACP00000023030	ENSLACP00000004468	Endoglin.	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.806