STRINGSTRING
H3AJR0_LATCH H3AJR0_LATCH LOC102360596 LOC102360596 H2ZS97_LATCH H2ZS97_LATCH RC3H2 RC3H2 ITGB6 ITGB6 H2ZSX8_LATCH H2ZSX8_LATCH LOC102360187 LOC102360187 H2ZTF7_LATCH H2ZTF7_LATCH TMEM98 TMEM98 CLCF1 CLCF1 NCAPH2 NCAPH2 H2ZV40_LATCH H2ZV40_LATCH ITGB8 ITGB8 FZD8 FZD8 APP APP JUNB JUNB IRF1 IRF1 ATP6AP1 ATP6AP1 GPR183 GPR183 H2ZX83_LATCH H2ZX83_LATCH CASP10 CASP10 FNIP1 FNIP1 LOC102362949 LOC102362949 CAMK4 CAMK4 GLO1 GLO1 PTGER4 PTGER4 LOC102348150 LOC102348150 GPR18 GPR18 MFNG MFNG EOMES EOMES BLNK BLNK BATF3 BATF3 BLK BLK GATA3 GATA3 PTPRC PTPRC TRAF6 TRAF6 LIG4 LIG4 ARMC5 ARMC5 H3A2R2_LATCH H3A2R2_LATCH FAM20C FAM20C MALT1 MALT1 GLI3 GLI3 CARD11 CARD11 LOC102358239 LOC102358239 KIT KIT TGFBR2 TGFBR2 GAB2 GAB2 RIPK2 RIPK2 H3A526_LATCH H3A526_LATCH RAG1 RAG1 NRARP NRARP RAG2 RAG2 ATM ATM JUN JUN LEF1 LEF1 CEBPG CEBPG PTPN2 PTPN2 TNFSF13B TNFSF13B LOC102359113 LOC102359113 LOC102362196 LOC102362196 NHEJ1 NHEJ1 ABL2 ABL2 LYN LYN CEBPA CEBPA CCR9 CCR9 BAX BAX TMEM64 TMEM64 H3AD77_LATCH H3AD77_LATCH CD79A CD79A SH2D6 SH2D6 CEBPE CEBPE H3AEV1_LATCH H3AEV1_LATCH NRROS NRROS CBFB CBFB LEPR LEPR ZAP70 ZAP70 DLL3 DLL3 H3AGM7_LATCH H3AGM7_LATCH LTBR LTBR HECTD1 HECTD1 SIRT1 SIRT1 PKNOX1 PKNOX1 TNFSF11 TNFSF11 LOC102352539 LOC102352539 IL6 IL6 SOCS1 SOCS1 DLL1 DLL1 IL18R1 IL18R1 FADD FADD RSAD2 RSAD2 GATA1 GATA1 HLX HLX LOC102346566 LOC102346566 LOC102362454 LOC102362454 TOX TOX SOX13 SOX13 H3AM65_LATCH H3AM65_LATCH ITM2A ITM2A MERTK MERTK PAX1 PAX1 THEMIS THEMIS LEP LEP DNAJB9 DNAJB9 FARP2 FARP2 EIF2AK1 EIF2AK1 ZBTB7A ZBTB7A SP3 SP3 LOC102358523 LOC102358523 LOC102358329 LOC102358329 ITFG2 ITFG2 RHOH RHOH BRAF BRAF PSEN1 PSEN1 LOC102361440 LOC102361440 TSC1 TSC1 IKZF3 IKZF3 SYK SYK STK11 STK11 RUNX2 RUNX2 MED1 MED1 EPHA2 EPHA2 IKZF1 IKZF1 TRAF3IP2 TRAF3IP2 STAT3 STAT3 DLL4 DLL4 LBR LBR SH3PXD2A SH3PXD2A FASN FASN JAG2 JAG2 EFNA2 EFNA2 NKX2-3 NKX2-3 ATG5 ATG5 FBXO7 FBXO7 CCR7 CCR7 CMTM7 CMTM7 TRPM2 TRPM2 JMJD6 JMJD6 H3B0U4_LATCH H3B0U4_LATCH SASH3 SASH3 RUNX3 RUNX3 SEMA4A SEMA4A LOC102363778 LOC102363778 TP53 TP53 GAS6 GAS6 CSF1R CSF1R SRF SRF TESPA1 TESPA1 H3B3K5_LATCH H3B3K5_LATCH SNX10 SNX10 H3B480_LATCH H3B480_LATCH LFNG LFNG JAGN1 JAGN1 PSMB11 PSMB11 CTNNB1 CTNNB1 LOC102358862 LOC102358862 RABL3 RABL3 PIR PIR RUNX1-2 RUNX1-2 ABL1 ABL1 CD40LG CD40LG NTRK1 NTRK1 LRRC8A LRRC8A LOC102353021 LOC102353021 RUNX1 RUNX1 CREB1 CREB1 CD74 CD74 BAK1 BAK1 H3B8U3_LATCH H3B8U3_LATCH RC3H1 RC3H1 ZBTB1 ZBTB1 GAB3 GAB3 DCAF1 DCAF1 LOC102363206 LOC102363206 TSHR TSHR MTOR MTOR TCF7 TCF7 H3BAX4_LATCH H3BAX4_LATCH DOCK10 DOCK10 TBX21 TBX21 NF1 NF1 LYL1 LYL1 TCTA TCTA AZI2 AZI2 RORA RORA TUSC2 TUSC2 RORC RORC BATF BATF SRP54 SRP54 LRRK1 LRRK1 AXL AXL TGFB1 TGFB1 FOS FOS ZFPM1 ZFPM1 TSPAN2 TSPAN2 H3BH49_LATCH H3BH49_LATCH H3BI75_LATCH H3BI75_LATCH WNT1 WNT1 LOC102356247 LOC102356247 IL6R IL6R DHRS7B DHRS7B CD3E CD3E LOC102348796 LOC102348796
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
H3AJR0_LATCHSRY-box transcription factor 13. (427 aa)
LOC102360596Uncharacterized protein. (238 aa)
H2ZS97_LATCHTNF_2 domain-containing protein. (143 aa)
RC3H2RING-type domain-containing protein. (352 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (675 aa)
H2ZSX8_LATCHFibronectin type-III domain-containing protein. (243 aa)
LOC102360187MutS homolog 2 (E. coli). (447 aa)
H2ZTF7_LATCHFam20C domain-containing protein. (511 aa)
TMEM98Transmembrane protein 98. (226 aa)
CLCF1Cardiotrophin like cytokine factor 1. (235 aa)
NCAPH2Non-SMC condensin II complex subunit H2. (617 aa)
H2ZV40_LATCHProtein kinase domain-containing protein. (266 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (637 aa)
FZD8Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (582 aa)
APPAmyloid beta precursor protein. (652 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (311 aa)
IRF1Interferon regulatory factor. (264 aa)
ATP6AP1ATPase H+ transporting accessory protein 1. (474 aa)
GPR183G protein-coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (363 aa)
H2ZX83_LATCHMutS homolog 2 (E. coli). (360 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (539 aa)
FNIP1Folliculin interacting protein 1. (1156 aa)
LOC102362949Uncharacterized protein. (1612 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (373 aa)
GLO1Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. (186 aa)
PTGER4Prostaglandin E receptor 4; Belongs to the G-protein coupled receptor 1 family. (455 aa)
LOC102348150Signal transducer and activator of transcription. (786 aa)
GPR18G protein-coupled receptor 18. (330 aa)
MFNGBeta-1,3-N-acetylglucosaminyltransferase. (321 aa)
EOMESEomesodermin. (419 aa)
BLNKB cell linker. (546 aa)
BATF3Basic leucine zipper ATF-like transcription factor 3. (74 aa)
BLKTyrosine-protein kinase. (447 aa)
GATA3GATA binding protein 3. (447 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (830 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (559 aa)
LIG4DNA ligase. (911 aa)
ARMC5Armadillo repeat containing 5. (811 aa)
H3A2R2_LATCHUncharacterized protein; Belongs to the peptidase C14A family. (480 aa)
FAM20CFam20C domain-containing protein. (305 aa)
MALT1MALT1 paracaspase. (825 aa)
GLI3GLI family zinc finger 3. (1456 aa)
CARD11Caspase recruitment domain family member 11. (1137 aa)
LOC102358239TRAF3 interacting protein 2-like. (392 aa)
KITKIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (937 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (585 aa)
GAB2GRB2 associated binding protein 2. (550 aa)
RIPK2Receptor interacting serine/threonine kinase 2. (567 aa)
H3A526_LATCHUncharacterized protein; Belongs to the peptidase C14A family. (486 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1045 aa)
NRARPNOTCH regulated ankyrin repeat protein. (112 aa)
RAG2Recombination activating 2. (522 aa)
ATMATM serine/threonine kinase. (2375 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (311 aa)
LEF1Lymphoid enhancer binding factor 1. (397 aa)
CEBPGCCAAT enhancer binding protein gamma. (150 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (397 aa)
TNFSF13BTNF superfamily member 13b; Belongs to the tumor necrosis factor family. (122 aa)
LOC102359113Uncharacterized protein. (455 aa)
LOC102362196Ig-like domain-containing protein. (206 aa)
NHEJ1Uncharacterized protein. (303 aa)
ABL2Tyrosine-protein kinase. (1175 aa)
LYNTyrosine-protein kinase. (515 aa)
CEBPACCAAT/enhancer-binding protein. (299 aa)
CCR9C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family. (369 aa)
BAXUncharacterized protein. (223 aa)
TMEM64Transmembrane protein 64. (350 aa)
H3AD77_LATCHJunE proto-oncogene, AP-1 transcription factor subunit. (316 aa)
CD79ACD79a molecule, immunoglobulin-associated alpha. (227 aa)
SH2D6SH2 domain-containing protein. (105 aa)
CEBPECCAAT/enhancer-binding protein. (273 aa)
H3AEV1_LATCHTNF_2 domain-containing protein. (230 aa)
NRROSNegative regulator of reactive oxygen species. (691 aa)
CBFBCore-binding factor subunit beta. (189 aa)
LEPRLeptin receptor. (1149 aa)
ZAP70Tyrosine-protein kinase. (609 aa)
DLL3Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (699 aa)
H3AGM7_LATCHFibronectin type-III domain-containing protein. (234 aa)
LTBRLymphotoxin beta receptor. (377 aa)
HECTD1HECT domain E3 ubiquitin protein ligase 1. (2580 aa)
SIRT1Sirtuin 1. (729 aa)
PKNOX1PBX/knotted 1 homeobox 1. (436 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (169 aa)
LOC102352539Uncharacterized protein. (949 aa)
IL6Uncharacterized protein. (149 aa)
SOCS1Suppressor of cytokine signaling 1a. (190 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
IL18R1TIR domain-containing protein. (153 aa)
FADDFas associated via death domain. (193 aa)
RSAD2Radical S-adenosyl methionine domain containing 2. (360 aa)
GATA1GATA binding protein 1b. (432 aa)
HLXH2.0 like homeobox. (384 aa)
LOC102346566Annexin. (343 aa)
LOC102362454Uncharacterized protein. (158 aa)
TOXThymocyte selection associated high mobility group box. (392 aa)
SOX13Uncharacterized protein. (195 aa)
H3AM65_LATCHMediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (472 aa)
ITM2AIntegral membrane protein 2A. (256 aa)
MERTKMER proto-oncogene, tyrosine kinase. (897 aa)
PAX1Paired box 1. (362 aa)
THEMISThymocyte selection associated. (564 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
DNAJB9DnaJ heat shock protein family (Hsp40) member B9. (219 aa)
FARP2FERM, ARH/RhoGEF and pleckstrin domain protein 2. (697 aa)
EIF2AK1Eukaryotic translation initiation factor 2 alpha kinase 1. (580 aa)
ZBTB7AZinc finger and BTB domain containing 7A. (518 aa)
SP3Sp3 transcription factor. (785 aa)
LOC102358523Uncharacterized protein. (424 aa)
LOC102358329TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (161 aa)
ITFG2Integrin alpha FG-GAP repeat containing 2. (445 aa)
RHOHRas homolog family member H. (189 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (768 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (465 aa)
LOC102361440Si:ch73-60h1.1. (384 aa)
TSC1TSC complex subunit 1. (1217 aa)
IKZF3IKAROS family zinc finger 3. (507 aa)
SYKTyrosine-protein kinase. (616 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (442 aa)
RUNX2Runt-related transcription factor. (452 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1401 aa)
EPHA2Uncharacterized protein. (979 aa)
IKZF1IKAROS family zinc finger 1. (468 aa)
TRAF3IP2SEFIR domain-containing protein. (379 aa)
STAT3Signal transducer and activator of transcription. (763 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (688 aa)
LBRLamin B receptor. (631 aa)
SH3PXD2ASH3 and PX domains 2A. (1118 aa)
FASNFatty acid synthase. (2502 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1106 aa)
EFNA2Ephrin A2; Belongs to the ephrin family. (139 aa)
NKX2-3NK2 homeobox 3. (334 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
FBXO7F-box protein 7. (482 aa)
CCR7C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (379 aa)
CMTM7CKLF like MARVEL transmembrane domain containing 7. (164 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2. (1473 aa)
JMJD6Jumonji domain containing 6, arginine demethylase and lysine hydroxylase. (403 aa)
H3B0U4_LATCHMALT paracaspase 2. (695 aa)
SASH3SAM and SH3 domain containing 3. (433 aa)
RUNX3RUNX family transcription factor 3. (179 aa)
SEMA4ASema domain-containing protein; Belongs to the semaphorin family. (758 aa)
LOC102363778J domain-containing protein. (211 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (401 aa)
GAS6Uncharacterized protein. (681 aa)
CSF1RColony stimulating factor 1 receptor. (968 aa)
SRFSerum response factor. (520 aa)
TESPA1KRAP_IP3R_bind domain-containing protein. (96 aa)
H3B3K5_LATCHUncharacterized protein. (213 aa)
SNX10Sorting nexin 10. (203 aa)
H3B480_LATCHUncharacterized protein. (567 aa)
LFNGBeta-1,3-N-acetylglucosaminyltransferase. (381 aa)
JAGN1Jagunal homolog 1. (183 aa)
PSMB11Proteasome subunit beta. (269 aa)
CTNNB1Catenin beta 1. (781 aa)
LOC102358862Proteasome subunit beta. (272 aa)
RABL3RAB, member of RAS oncogene family like 3. (218 aa)
PIRPirin; Belongs to the pirin family. (171 aa)
RUNX1-2RUNX family transcription factor 1. (242 aa)
ABL1Tyrosine-protein kinase. (1156 aa)
CD40LGCD40 ligand; Belongs to the tumor necrosis factor family. (284 aa)
NTRK1Tyrosine-protein kinase receptor. (747 aa)
LRRC8ALeucine rich repeat containing 8 VRAC subunit A. (809 aa)
LOC102353021Uncharacterized protein. (644 aa)
RUNX1Runt domain-containing protein. (191 aa)
CREB1cAMP responsive element binding protein 1. (347 aa)
CD74CD74 molecule. (279 aa)
BAK1BCL2 antagonist/killer 1. (239 aa)
H3B8U3_LATCHSerine/threonine-protein kinase TOR. (1418 aa)
RC3H1Ring finger and CCCH-type domains 1. (1123 aa)
ZBTB1Zinc finger and BTB domain containing 1. (706 aa)
GAB3GRB2 associated binding protein 3. (603 aa)
DCAF1DDB1 and CUL4 associated factor 1. (1510 aa)
LOC102363206Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (575 aa)
TSHRThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (689 aa)
MTORMechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family. (1009 aa)
TCF7Transcription factor 7. (343 aa)
H3BAX4_LATCHDC_STAMP domain-containing protein. (450 aa)
DOCK10Dedicator of cytokinesis 10; Belongs to the DOCK family. (2199 aa)
TBX21T-box transcription factor 21. (570 aa)
NF1Neurofibromin 1. (2814 aa)
LYL1BHLH domain-containing protein. (242 aa)
TCTAT-cell leukemia translocation-altered gene protein homolog. (102 aa)
AZI25-azacytidine induced 2. (394 aa)
RORARAR related orphan receptor A. (468 aa)
TUSC2Tumor suppressor 2, mitochondrial calcium regulator. (111 aa)
RORCRAR related orphan receptor C. (502 aa)
BATFBasic leucine zipper ATF-like transcription factor. (119 aa)
SRP54Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily. (504 aa)
LRRK1Leucine rich repeat kinase 1. (1987 aa)
AXLAXL receptor tyrosine kinase. (872 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (391 aa)
ZFPM1Zinc finger protein, FOG family member 1. (1017 aa)
TSPAN2Tetraspanin. (221 aa)
H3BH49_LATCHIg-like domain-containing protein. (195 aa)
H3BI75_LATCHUncharacterized protein. (110 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (373 aa)
LOC102356247Uncharacterized protein. (636 aa)
IL6RInterleukin 6 receptor. (469 aa)
DHRS7BDehydrogenase/reductase 7B; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (323 aa)
CD3ECD3e molecule. (191 aa)
LOC102348796Uncharacterized protein. (497 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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