(21 nodes) Response to ischemia network (Latimeria chalumnae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	RNLS	Renalase, FAD dependent amine oxidase. (254 aa)
	AIFM1	Apoptosis inducing factor mitochondria associated 1. (625 aa)
	EEF2K	Eukaryotic elongation factor 2 kinase. (512 aa)
	H2ZYB6_LATCH	Uncharacterized protein. (324 aa)
	SLC26A5	Solute carrier family 26 member 5. (755 aa)
	PANX1	Pannexin; Structural component of the gap junctions and the hemichannels. (428 aa)
	LOC102351267	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (338 aa)
	MLYCD	Malonyl-CoA decarboxylase. (480 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1077 aa)
	ABRAXAS2	Abraxas 2, BRISC complex subunit. (409 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (401 aa)
	CSF1R	Colony stimulating factor 1 receptor. (968 aa)
	MAP2K6	Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (332 aa)
	CIB1	Calcium and integrin binding 1. (190 aa)
	PANX2	Pannexin; Structural component of the gap junctions and the hemichannels; Belongs to the pannexin family. (681 aa)
	PINK1	PTEN induced kinase 1. (467 aa)
	TIGAR	TP53 induced glycolysis regulatory phosphatase. (212 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (457 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (153 aa)
	LOC102356247	Uncharacterized protein. (636 aa)
	P2RX4	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (391 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIFM1	CASP9	ENSLACP00000001333	ENSLACP00000020786	Apoptosis inducing factor mitochondria associated 1.	Caspase 9; Belongs to the peptidase C14A family.	0.587
CASP9	AIFM1	ENSLACP00000020786	ENSLACP00000001333	Caspase 9; Belongs to the peptidase C14A family.	Apoptosis inducing factor mitochondria associated 1.	0.587
CASP9	TP53	ENSLACP00000020786	ENSLACP00000015915	Caspase 9; Belongs to the peptidase C14A family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.731
CSF1R	LOC102356247	ENSLACP00000016266	ENSLACP00000022371	Colony stimulating factor 1 receptor.	Uncharacterized protein.	0.951
CSF1R	PIK3CB	ENSLACP00000016266	ENSLACP00000014968	Colony stimulating factor 1 receptor.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.475
LOC102351267	MAP2K6	ENSLACP00000009926	ENSLACP00000017172	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.	0.901
LOC102356247	CSF1R	ENSLACP00000022371	ENSLACP00000016266	Uncharacterized protein.	Colony stimulating factor 1 receptor.	0.951
MAP2K6	LOC102351267	ENSLACP00000017172	ENSLACP00000009926	Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.901
P2RX4	PANX1	ENSLACP00000022710	ENSLACP00000005461	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	Pannexin; Structural component of the gap junctions and the hemichannels.	0.467
PANX1	P2RX4	ENSLACP00000005461	ENSLACP00000022710	Pannexin; Structural component of the gap junctions and the hemichannels.	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.	0.467
PANX1	PANX2	ENSLACP00000005461	ENSLACP00000019572	Pannexin; Structural component of the gap junctions and the hemichannels.	Pannexin; Structural component of the gap junctions and the hemichannels; Belongs to the pannexin family.	0.882
PANX2	PANX1	ENSLACP00000019572	ENSLACP00000005461	Pannexin; Structural component of the gap junctions and the hemichannels; Belongs to the pannexin family.	Pannexin; Structural component of the gap junctions and the hemichannels.	0.882
PIK3CB	CSF1R	ENSLACP00000014968	ENSLACP00000016266	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	Colony stimulating factor 1 receptor.	0.475
TIGAR	TP53	ENSLACP00000020459	ENSLACP00000015915	TP53 induced glycolysis regulatory phosphatase.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.645
TP53	CASP9	ENSLACP00000015915	ENSLACP00000020786	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Caspase 9; Belongs to the peptidase C14A family.	0.731
TP53	TIGAR	ENSLACP00000015915	ENSLACP00000020459	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	TP53 induced glycolysis regulatory phosphatase.	0.645