STRINGSTRING
TBX19 TBX19 NOTO NOTO NPY2R NPY2R SUFU SUFU NPY5R NPY5R H3AM65_LATCH H3AM65_LATCH SETDB2 SETDB2 TEK TEK ACVR1 ACVR1 H3APB2_LATCH H3APB2_LATCH LOC102353564 LOC102353564 EFNA1 EFNA1 DHRS3 DHRS3 STIL STIL NSD2 NSD2 TBX20 TBX20 SLIT2 SLIT2 TNNI1 TNNI1 LOC102365298 LOC102365298 PSEN1 PSEN1 ZFPM2 ZFPM2 TAB1 TAB1 JAG1 JAG1 LOC102364341 LOC102364341 HTR2B HTR2B DNAAF1 DNAAF1 GJA5 GJA5 TNNI3 TNNI3 SMO SMO MTOR MTOR GATA6 GATA6 H3A007_LATCH H3A007_LATCH LOC102350164 LOC102350164 H3A0S5_LATCH H3A0S5_LATCH CCM2L CCM2L GATA3 GATA3 ASB2 ASB2 PTCH1 PTCH1 SOS1 SOS1 TGFBR2 TGFBR2 MSX1 MSX1 HAND2 HAND2 PKD2 PKD2 LOC102356523 LOC102356523 TBX6 TBX6 JUN JUN ARID2 ARID2 NIPBL NIPBL SMAD6 SMAD6 SNAI2 SNAI2 EDNRA EDNRA SMAD7 SMAD7 WNT11 WNT11 ILK ILK KDM6A KDM6A TMED2 TMED2 LOC102352268 LOC102352268 MDM4 MDM4 CCN1 CCN1 BMP7 BMP7 SNAI1 SNAI1 CCDC40 CCDC40 FLRT2 FLRT2 H3BEX6_LATCH H3BEX6_LATCH WNT2B WNT2B TGFB1 TGFB1 H3BFW7_LATCH H3BFW7_LATCH H3BFZ2_LATCH H3BFZ2_LATCH ZFPM1 ZFPM1 TNNC1 TNNC1 HAND1 HAND1 MKS1 MKS1 IFT52 IFT52 BMP4 BMP4 ACVRL1 ACVRL1 LOC102358988 LOC102358988 CPE CPE LOC102356233 LOC102356233 ENG ENG SLIT3 SLIT3 PKP2 PKP2 GATA4 GATA4 TBX3 TBX3 H3AC70_LATCH H3AC70_LATCH SEC24B SEC24B SFRP2 SFRP2 ZMPSTE24 ZMPSTE24 H3AD77_LATCH H3AD77_LATCH TGFB2 TGFB2 FGF8 FGF8 TGFBR1 TGFBR1 ARL13B ARL13B WNT16 WNT16 MIB1 MIB1 CLUAP1 CLUAP1 DLL3 DLL3 LOC102351081 LOC102351081 SMAD4 SMAD4 SEMA3C SEMA3C DLL1 DLL1 TMEM100 TMEM100 S1PR2 S1PR2 LOC102355487 LOC102355487 EDN1 EDN1 LEMD2 LEMD2 H3B8U3_LATCH H3B8U3_LATCH WNT2 WNT2 LOC102366172 LOC102366172 TAZ TAZ LOC102365660 LOC102365660 TBXT TBXT TBX2 TBX2 BMPR2 BMPR2 NKX2-5 NKX2-5 LOC102350553 LOC102350553 POPDC2 POPDC2 GATA5 GATA5 SRF SRF BMP2 BMP2 PTCD2 PTCD2 TP53 TP53 LOC102349513 LOC102349513 NRP2 NRP2 CCDC103 CCDC103 CRKL CRKL LOC102345533 LOC102345533 ALCAM ALCAM RBM20 RBM20 H3AXS1_LATCH H3AXS1_LATCH SAV1 SAV1 H3AVW8_LATCH H3AVW8_LATCH PLXND1 PLXND1 DLL4 DLL4 IFT57 IFT57 ANKRD1 ANKRD1 MED1 MED1 MICAL2 MICAL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TBX19T-box transcription factor 19. (373 aa)
NOTOHomeobox domain-containing protein. (234 aa)
NPY2RNeuropeptide Y receptor Y2; Belongs to the G-protein coupled receptor 1 family. (378 aa)
SUFUSUFU negative regulator of hedgehog signaling. (422 aa)
NPY5RNeuropeptide Y receptor Y5. (446 aa)
H3AM65_LATCHMediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (472 aa)
SETDB2SET domain bifurcated histone lysine methyltransferase 2. (751 aa)
TEKTEK receptor tyrosine kinase. (914 aa)
ACVR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
H3APB2_LATCHFork-head domain-containing protein. (408 aa)
LOC102353564Uncharacterized protein. (161 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (176 aa)
DHRS3Dehydrogenase/reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (303 aa)
STILSTIL centriolar assembly protein. (1298 aa)
NSD2Nuclear receptor binding SET domain protein 2. (1348 aa)
TBX20T-box transcription factor 20. (441 aa)
SLIT2Slit guidance ligand 2. (1372 aa)
TNNI1Troponin I1, slow skeletal type. (171 aa)
LOC102365298Uncharacterized protein. (427 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (465 aa)
ZFPM2Zinc finger protein, FOG family member 2. (979 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (436 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1220 aa)
LOC102364341Uncharacterized protein. (271 aa)
HTR2B5-hydroxytryptamine receptor 2B. (474 aa)
DNAAF1Dynein assembly factor 1, axonemal. (263 aa)
GJA5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (371 aa)
TNNI3Uncharacterized protein. (240 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (820 aa)
MTORMechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family. (1009 aa)
GATA6GATA binding protein 6. (503 aa)
H3A007_LATCHUncharacterized protein. (52 aa)
LOC102350164Uncharacterized protein. (364 aa)
H3A0S5_LATCHUncharacterized protein. (547 aa)
CCM2LCCM2 like scaffold protein. (594 aa)
GATA3GATA binding protein 3. (447 aa)
ASB2Ankyrin repeat and SOCS box containing 2. (658 aa)
PTCH1Patched 1. (1287 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1331 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (585 aa)
MSX1Msh homeobox 1. (256 aa)
HAND2Heart and neural crest derivatives expressed 2. (210 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (890 aa)
LOC102356523Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (510 aa)
TBX6Uncharacterized protein. (101 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (311 aa)
ARID2AT-rich interaction domain 2. (1771 aa)
NIPBLNipped-B protein. (2707 aa)
SMAD6Mothers against decapentaplegic homolog. (485 aa)
SNAI2Snail family zinc finger 2. (268 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (424 aa)
SMAD7Mothers against decapentaplegic homolog. (377 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
ILKIntegrin linked kinase. (417 aa)
KDM6ALysine (K)-specific demethylase 6A. (1452 aa)
TMED2Transmembrane p24 trafficking protein 2. (208 aa)
LOC102352268Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (491 aa)
CCN1Cellular communication network factor 1. (368 aa)
BMP7Bone morphogenetic protein 7. (425 aa)
SNAI1Snail family transcriptional repressor 1. (257 aa)
CCDC40Coiled-coil domain containing 40. (859 aa)
FLRT2Fibronectin leucine rich transmembrane protein 2. (656 aa)
H3BEX6_LATCHReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (307 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
H3BFW7_LATCHBHLH domain-containing protein. (161 aa)
H3BFZ2_LATCHBHLH domain-containing protein. (165 aa)
ZFPM1Zinc finger protein, FOG family member 1. (1017 aa)
TNNC1Troponin C type 1a (slow). (164 aa)
HAND1Heart and neural crest derivatives expressed 1. (196 aa)
MKS1MKS transition zone complex subunit 1. (561 aa)
IFT52Intraflagellar transport 52. (440 aa)
BMP4Bone morphogenetic protein 4. (460 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (497 aa)
LOC102358988Mothers against decapentaplegic homolog. (614 aa)
CPECarboxypeptidase E. (469 aa)
LOC102356233TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (574 aa)
ENGEndoglin. (674 aa)
SLIT3Slit guidance ligand 3. (635 aa)
PKP2Uncharacterized protein. (815 aa)
GATA4GATA binding protein 4. (402 aa)
TBX3T-box transcription factor 3. (713 aa)
H3AC70_LATCHLRRNT domain-containing protein. (132 aa)
SEC24BSEC24 homolog B, COPII coat complex component. (1197 aa)
SFRP2Secreted frizzled related protein 2. (294 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (453 aa)
H3AD77_LATCHJunE proto-oncogene, AP-1 transcription factor subunit. (316 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
TGFBR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
ARL13BADP ribosylation factor like GTPase 13B. (343 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
MIB1Mindbomb E3 ubiquitin protein ligase 1. (989 aa)
CLUAP1Clusterin associated protein 1. (348 aa)
DLL3Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (699 aa)
LOC102351081Bone morphogenetic protein 16. (396 aa)
SMAD4MH2 domain-containing protein. (412 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (550 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
TMEM100Transmembrane protein 100. (134 aa)
S1PR2Sphingosine-1-phosphate receptor 2. (352 aa)
LOC102355487Notochord homeobox. (242 aa)
EDN1Endothelin 1. (216 aa)
LEMD2LEM domain containing 2. (416 aa)
H3B8U3_LATCHSerine/threonine-protein kinase TOR. (1418 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
LOC102366172Uncharacterized protein. (183 aa)
TAZTafazzin family protein; Belongs to the taffazin family. (264 aa)
LOC102365660Uncharacterized protein. (187 aa)
TBXTT-box transcription factor T. (434 aa)
TBX2T-box transcription factor 2. (689 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1037 aa)
NKX2-5NK2 homeobox 5. (296 aa)
LOC102350553Uncharacterized protein. (232 aa)
POPDC2Popeye domain containing 2. (366 aa)
GATA5GATA binding protein 5. (395 aa)
SRFSerum response factor. (520 aa)
BMP2Bone morphogenetic protein 2. (402 aa)
PTCD2Pentatricopeptide repeat domain 2. (405 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (401 aa)
LOC102349513Neuropeptide Y receptor Y7; Belongs to the G-protein coupled receptor 1 family. (382 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (929 aa)
CCDC103Coiled-coil domain containing 103. (265 aa)
CRKLCRK like proto-oncogene, adaptor protein. (219 aa)
LOC102345533T-box transcription factor 16. (438 aa)
ALCAMActivated leukocyte cell adhesion molecule. (530 aa)
RBM20RNA binding motif protein 20. (1197 aa)
H3AXS1_LATCHProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (313 aa)
SAV1Salvador family WW domain containing protein 1. (393 aa)
H3AVW8_LATCHMothers against decapentaplegic homolog. (369 aa)
PLXND1Plexin D1. (1875 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (688 aa)
IFT57Intraflagellar transport 57. (428 aa)
ANKRD1Ankyrin repeat domain 1. (319 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1401 aa)
MICAL2Microtubule associated monooxygenase, calponin and LIM domain containing 2. (1131 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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