(38 nodes) Renal system process network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DRD2	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (450 aa)
	PTPRO	Protein tyrosine phosphatase receptor type O. (1222 aa)
	ABCG2	ABC transporter domain-containing protein. (607 aa)
	GJA5	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (371 aa)
	PDGFB	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (209 aa)
	AKAP11	A-kinase anchoring protein 11. (1808 aa)
	SERPINF2	Serpin family F member 2; Belongs to the serpin family. (394 aa)
	CLN3	Battenin. (406 aa)
	ITGA3	Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1012 aa)
	H3A5I8_LATCH	ABC transporter domain-containing protein. (665 aa)
	XPNPEP3	X-prolyl aminopeptidase 3. (466 aa)
	LOC102364659	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (319 aa)
	EDNRA	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (424 aa)
	LOC102351334	Scinderin like a. (721 aa)
	AGTR1	Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (357 aa)
	NPR3	Natriuretic peptide receptor 3. (483 aa)
	RHPN2	Rhophilin Rho GTPase binding protein 2. (684 aa)
	INPP5K	Inositol polyphosphate-5-phosphatase K. (476 aa)
	H3AEK5_LATCH	Aquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (268 aa)
	LOC102358221	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (439 aa)
	SLC5A2	Solute carrier family 5 member 2; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (691 aa)
	H3AHJ4_LATCH	Ion_trans domain-containing protein; Belongs to the potassium channel family. (298 aa)
	SULF2	Extracellular sulfatase. (877 aa)
	AMN	Amnion associated transmembrane protein. (492 aa)
	KCNQ1	Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (351 aa)
	LOC102361283	ATP-binding cassette, sub-family G (WHITE), member 2b. (634 aa)
	EMP2	Epithelial membrane protein 2. (160 aa)
	WFS1	Wolframin ER transmembrane glycoprotein. (876 aa)
	TMEM63C	Transmembrane protein 63C. (830 aa)
	EDNRB	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (440 aa)
	GAS6	Uncharacterized protein. (681 aa)
	CLCN5	Chloride channel protein. (781 aa)
	SULF1	Sulfatase 1. (1129 aa)
	EDN1	Endothelin 1. (216 aa)
	CD34	Uncharacterized protein. (378 aa)
	LGMN	Legumain. (436 aa)
	AGT	SERPIN domain-containing protein; Belongs to the serpin family. (470 aa)
	JCHAIN	Joining chain of multimeric IgA and IgM. (144 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCG2	CD34	ENSLACP00000001331	ENSLACP00000021425	ABC transporter domain-containing protein.	Uncharacterized protein.	0.423
ABCG2	H3A5I8_LATCH	ENSLACP00000001331	ENSLACP00000004909	ABC transporter domain-containing protein.	ABC transporter domain-containing protein.	0.901
ABCG2	LOC102361283	ENSLACP00000001331	ENSLACP00000010788	ABC transporter domain-containing protein.	ATP-binding cassette, sub-family G (WHITE), member 2b.	0.904
AGT	AGTR1	ENSLACP00000023240	ENSLACP00000006853	SERPIN domain-containing protein; Belongs to the serpin family.	Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family.	0.999
AGT	EDN1	ENSLACP00000023240	ENSLACP00000018825	SERPIN domain-containing protein; Belongs to the serpin family.	Endothelin 1.	0.774
AGT	EDNRA	ENSLACP00000023240	ENSLACP00000006100	SERPIN domain-containing protein; Belongs to the serpin family.	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	0.818
AGT	EDNRB	ENSLACP00000023240	ENSLACP00000014962	SERPIN domain-containing protein; Belongs to the serpin family.	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family.	0.637
AGT	LOC102358221	ENSLACP00000023240	ENSLACP00000008101	SERPIN domain-containing protein; Belongs to the serpin family.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.637
AGT	LOC102364659	ENSLACP00000023240	ENSLACP00000006081	SERPIN domain-containing protein; Belongs to the serpin family.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.973
AGTR1	AGT	ENSLACP00000006853	ENSLACP00000023240	Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family.	SERPIN domain-containing protein; Belongs to the serpin family.	0.999
AGTR1	EDN1	ENSLACP00000006853	ENSLACP00000018825	Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family.	Endothelin 1.	0.774
AGTR1	EDNRA	ENSLACP00000006853	ENSLACP00000006100	Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family.	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	0.488
CD34	ABCG2	ENSLACP00000021425	ENSLACP00000001331	Uncharacterized protein.	ABC transporter domain-containing protein.	0.423
EDN1	AGT	ENSLACP00000018825	ENSLACP00000023240	Endothelin 1.	SERPIN domain-containing protein; Belongs to the serpin family.	0.774
EDN1	AGTR1	ENSLACP00000018825	ENSLACP00000006853	Endothelin 1.	Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family.	0.774
EDN1	EDNRA	ENSLACP00000018825	ENSLACP00000006100	Endothelin 1.	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	0.999
EDN1	EDNRB	ENSLACP00000018825	ENSLACP00000014962	Endothelin 1.	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family.	0.998
EDN1	LOC102358221	ENSLACP00000018825	ENSLACP00000008101	Endothelin 1.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.996
EDN1	LOC102364659	ENSLACP00000018825	ENSLACP00000006081	Endothelin 1.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.719
EDNRA	AGT	ENSLACP00000006100	ENSLACP00000023240	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	SERPIN domain-containing protein; Belongs to the serpin family.	0.818