(15 nodes) Regulation of animal organ formation network (Latimeria chalumnae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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gene neighborhood

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textmining

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Your Input:
	LOC102358266	Dickkopf WNT signaling pathway inhibitor 1b. (261 aa)
	GDNF	Glial cell derived neurotrophic factor. (222 aa)
	FRS2	Fibroblast growth factor receptor substrate 2. (502 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	HOXD11	Homeobox D11. (294 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	BMP2	Bone morphogenetic protein 2. (402 aa)
	AR	Androgen receptor. (412 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	SPRY1	Sprouty RTK signaling antagonist 1. (320 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
	SULF1	Sulfatase 1. (1129 aa)
	HOXC11	Homeobox C11. (301 aa)
	WNT2B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	BMP4	Bone morphogenetic protein 4. (460 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AR	CTNNB1	ENSLACP00000017054	ENSLACP00000017209	Androgen receptor.	Catenin beta 1.	0.933
BMP2	BMP4	ENSLACP00000016168	ENSLACP00000021723	Bone morphogenetic protein 2.	Bone morphogenetic protein 4.	0.903
BMP2	FGF1	ENSLACP00000016168	ENSLACP00000015106	Bone morphogenetic protein 2.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.401
BMP2	FGF8	ENSLACP00000016168	ENSLACP00000007843	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.421
BMP4	BMP2	ENSLACP00000021723	ENSLACP00000016168	Bone morphogenetic protein 4.	Bone morphogenetic protein 2.	0.903
BMP4	FGF1	ENSLACP00000021723	ENSLACP00000015106	Bone morphogenetic protein 4.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.499
BMP4	FGF8	ENSLACP00000021723	ENSLACP00000007843	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.642
CTNNB1	AR	ENSLACP00000017209	ENSLACP00000017054	Catenin beta 1.	Androgen receptor.	0.933
CTNNB1	FGF8	ENSLACP00000017209	ENSLACP00000007843	Catenin beta 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.437
CTNNB1	LOC102358266	ENSLACP00000017209	ENSLACP00000005525	Catenin beta 1.	Dickkopf WNT signaling pathway inhibitor 1b.	0.652
CTNNB1	WNT2	ENSLACP00000017209	ENSLACP00000017997	Catenin beta 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.589
CTNNB1	WNT2B	ENSLACP00000017209	ENSLACP00000020566	Catenin beta 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.589
FGF1	BMP2	ENSLACP00000015106	ENSLACP00000016168	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Bone morphogenetic protein 2.	0.401
FGF1	BMP4	ENSLACP00000015106	ENSLACP00000021723	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Bone morphogenetic protein 4.	0.499
FGF1	FGF8	ENSLACP00000015106	ENSLACP00000007843	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.581
FGF1	FRS2	ENSLACP00000015106	ENSLACP00000007102	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor receptor substrate 2.	0.631
FGF8	BMP2	ENSLACP00000007843	ENSLACP00000016168	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Bone morphogenetic protein 2.	0.421
FGF8	BMP4	ENSLACP00000007843	ENSLACP00000021723	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Bone morphogenetic protein 4.	0.642
FGF8	CTNNB1	ENSLACP00000007843	ENSLACP00000017209	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Catenin beta 1.	0.437
FGF8	FGF1	ENSLACP00000007843	ENSLACP00000015106	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.581