(17 nodes) Aortic valve development network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SLIT3	Slit guidance ligand 3. (635 aa)
	GATA3	GATA binding protein 3. (447 aa)
	RB1	Uncharacterized protein. (411 aa)
	SMAD6	Mothers against decapentaplegic homolog. (485 aa)
	GATA4	GATA binding protein 4. (402 aa)
	H3AC70_LATCH	LRRNT domain-containing protein. (132 aa)
	TIE1	Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1143 aa)
	LOC102356355	TNFR-Cys domain-containing protein. (163 aa)
	EMILIN1	Elastin microfibril interfacer 1. (1047 aa)
	EFNA1	Ephrin A1; Belongs to the ephrin family. (176 aa)
	TBX20	T-box transcription factor 20. (441 aa)
	SLIT2	Slit guidance ligand 2. (1372 aa)
	GATA5	GATA binding protein 5. (395 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1037 aa)
	H3BEX6_LATCH	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (307 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
	TNFRSF1B	TNF receptor superfamily member 1B. (465 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMPR2	SMAD6	ENSLACP00000017144	ENSLACP00000006043	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Mothers against decapentaplegic homolog.	0.671
BMPR2	TGFB1	ENSLACP00000017144	ENSLACP00000020652	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.438
GATA3	GATA4	ENSLACP00000003446	ENSLACP00000006941	GATA binding protein 3.	GATA binding protein 4.	0.404
GATA3	GATA5	ENSLACP00000003446	ENSLACP00000016394	GATA binding protein 3.	GATA binding protein 5.	0.404
GATA4	GATA3	ENSLACP00000006941	ENSLACP00000003446	GATA binding protein 4.	GATA binding protein 3.	0.404
GATA4	TBX20	ENSLACP00000006941	ENSLACP00000012205	GATA binding protein 4.	T-box transcription factor 20.	0.637
GATA5	GATA3	ENSLACP00000016394	ENSLACP00000003446	GATA binding protein 5.	GATA binding protein 3.	0.404
GATA5	TBX20	ENSLACP00000016394	ENSLACP00000012205	GATA binding protein 5.	T-box transcription factor 20.	0.592
H3AC70_LATCH	SLIT2	ENSLACP00000007241	ENSLACP00000012299	LRRNT domain-containing protein.	Slit guidance ligand 2.	0.900
H3AC70_LATCH	SLIT3	ENSLACP00000007241	ENSLACP00000023414	LRRNT domain-containing protein.	Slit guidance ligand 3.	0.910
H3BEX6_LATCH	SMAD6	ENSLACP00000020447	ENSLACP00000006043	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Mothers against decapentaplegic homolog.	0.671
H3BEX6_LATCH	TGFB1	ENSLACP00000020447	ENSLACP00000020652	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.438
LOC102356355	TNFRSF1B	ENSLACP00000010674	ENSLACP00000023381	TNFR-Cys domain-containing protein.	TNF receptor superfamily member 1B.	0.876
SLIT2	H3AC70_LATCH	ENSLACP00000012299	ENSLACP00000007241	Slit guidance ligand 2.	LRRNT domain-containing protein.	0.900
SLIT3	H3AC70_LATCH	ENSLACP00000023414	ENSLACP00000007241	Slit guidance ligand 3.	LRRNT domain-containing protein.	0.910
SMAD6	BMPR2	ENSLACP00000006043	ENSLACP00000017144	Mothers against decapentaplegic homolog.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.671
SMAD6	H3BEX6_LATCH	ENSLACP00000006043	ENSLACP00000020447	Mothers against decapentaplegic homolog.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.671
SMAD6	TGFB1	ENSLACP00000006043	ENSLACP00000020652	Mothers against decapentaplegic homolog.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.767
TBX20	GATA4	ENSLACP00000012205	ENSLACP00000006941	T-box transcription factor 20.	GATA binding protein 4.	0.637
TBX20	GATA5	ENSLACP00000012205	ENSLACP00000016394	T-box transcription factor 20.	GATA binding protein 5.	0.592