STRINGSTRING
JAG1 JAG1 TGFBR2 TGFBR2 MSX1 MSX1 LOC102356523 LOC102356523 SNAI2 SNAI2 GATA4 GATA4 TBX3 TBX3 FGF8 FGF8 SMAD4 SMAD4 ACVR1 ACVR1 TBX20 TBX20 TMEM100 TMEM100 GATA5 GATA5 BMPR2 BMPR2 TBX2 TBX2 CRELD1 CRELD1 MDM4 MDM4 BMP7 BMP7 SNAI1 SNAI1 H3BEX6_LATCH H3BEX6_LATCH ACVRL1 ACVRL1 LOC102358988 LOC102358988 ENG ENG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1220 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (585 aa)
MSX1Msh homeobox 1. (256 aa)
LOC102356523Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (510 aa)
SNAI2Snail family zinc finger 2. (268 aa)
GATA4GATA binding protein 4. (402 aa)
TBX3T-box transcription factor 3. (713 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
SMAD4MH2 domain-containing protein. (412 aa)
ACVR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
TBX20T-box transcription factor 20. (441 aa)
TMEM100Transmembrane protein 100. (134 aa)
GATA5GATA binding protein 5. (395 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1037 aa)
TBX2T-box transcription factor 2. (689 aa)
CRELD1Cysteine rich with EGF like domains 1. (338 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (491 aa)
BMP7Bone morphogenetic protein 7. (425 aa)
SNAI1Snail family transcriptional repressor 1. (257 aa)
H3BEX6_LATCHReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (307 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (497 aa)
LOC102358988Mothers against decapentaplegic homolog. (614 aa)
ENGEndoglin. (674 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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