(12 nodes) Endocardial cushion formation network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENG	Endoglin. (674 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	TBX3	T-box transcription factor 3. (713 aa)
	SNAI2	Snail family zinc finger 2. (268 aa)
	SMAD4	MH2 domain-containing protein. (412 aa)
	TBX20	T-box transcription factor 20. (441 aa)
	TMEM100	Transmembrane protein 100. (134 aa)
	TBX2	T-box transcription factor 2. (689 aa)
	BMP7	Bone morphogenetic protein 7. (425 aa)
	SNAI1	Snail family transcriptional repressor 1. (257 aa)
	LOC102358988	Mothers against decapentaplegic homolog. (614 aa)
	MSX1	Msh homeobox 1. (256 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP7	FGF8	ENSLACP00000019986	ENSLACP00000007843	Bone morphogenetic protein 7.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.452
BMP7	MSX1	ENSLACP00000019986	ENSLACP00000004473	Bone morphogenetic protein 7.	Msh homeobox 1.	0.529
BMP7	SMAD4	ENSLACP00000019986	ENSLACP00000009312	Bone morphogenetic protein 7.	MH2 domain-containing protein.	0.519
FGF8	BMP7	ENSLACP00000007843	ENSLACP00000019986	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Bone morphogenetic protein 7.	0.452
FGF8	MSX1	ENSLACP00000007843	ENSLACP00000004473	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Msh homeobox 1.	0.606
LOC102358988	SMAD4	ENSLACP00000022115	ENSLACP00000009312	Mothers against decapentaplegic homolog.	MH2 domain-containing protein.	0.901
MSX1	BMP7	ENSLACP00000004473	ENSLACP00000019986	Msh homeobox 1.	Bone morphogenetic protein 7.	0.529
MSX1	FGF8	ENSLACP00000004473	ENSLACP00000007843	Msh homeobox 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.606
MSX1	SNAI1	ENSLACP00000004473	ENSLACP00000020148	Msh homeobox 1.	Snail family transcriptional repressor 1.	0.525
MSX1	SNAI2	ENSLACP00000004473	ENSLACP00000006099	Msh homeobox 1.	Snail family zinc finger 2.	0.526
SMAD4	BMP7	ENSLACP00000009312	ENSLACP00000019986	MH2 domain-containing protein.	Bone morphogenetic protein 7.	0.519
SMAD4	LOC102358988	ENSLACP00000009312	ENSLACP00000022115	MH2 domain-containing protein.	Mothers against decapentaplegic homolog.	0.901
SNAI1	MSX1	ENSLACP00000020148	ENSLACP00000004473	Snail family transcriptional repressor 1.	Msh homeobox 1.	0.525
SNAI2	MSX1	ENSLACP00000006099	ENSLACP00000004473	Snail family zinc finger 2.	Msh homeobox 1.	0.526