(26 nodes) Leukocyte cell-cell adhesion network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102349637	Uncharacterized protein. (767 aa)
	H2ZS97_LATCH	TNF_2 domain-containing protein. (143 aa)
	LOC102347948	Uncharacterized protein. (290 aa)
	LRG1	LRRCT domain-containing protein. (337 aa)
	H2ZXZ3_LATCH	L-selectin; Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia. (385 aa)
	GOLPH3	Golgi phosphoprotein 3. (294 aa)
	H2ZZU4_LATCH	Selectin E. (554 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (830 aa)
	SEMA4D	Semaphorin 4D; Belongs to the semaphorin family. (862 aa)
	EZR	Ezrin. (591 aa)
	JAM2	Junctional adhesion molecule 2. (292 aa)
	H3AEV1_LATCH	TNF_2 domain-containing protein. (230 aa)
	NT5E	5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. (469 aa)
	LOC102366200	Uncharacterized protein; Belongs to the semaphorin family. (627 aa)
	PODXL2	Podocalyxin like 2. (548 aa)
	SYK	Tyrosine-protein kinase. (616 aa)
	TNIP3	TNFAIP3 interacting protein 3. (269 aa)
	ROCK1	Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1350 aa)
	ITGA4	Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1037 aa)
	MSN	Moesin. (583 aa)
	H3B5Z8_LATCH	Uncharacterized protein. (606 aa)
	LOC102354417	Uncharacterized protein. (723 aa)
	FERMT3	Fermitin family member 3. (653 aa)
	TNIP1	TNFAIP3 interacting protein 1. (532 aa)
	ADD2	Adducin 2. (742 aa)
	LOC102365550	Uncharacterized protein. (218 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EZR	FERMT3	ENSLACP00000006611	ENSLACP00000019184	Ezrin.	Fermitin family member 3.	0.535
EZR	MSN	ENSLACP00000006611	ENSLACP00000017220	Ezrin.	Moesin.	0.973
FERMT3	EZR	ENSLACP00000019184	ENSLACP00000006611	Fermitin family member 3.	Ezrin.	0.535
FERMT3	MSN	ENSLACP00000019184	ENSLACP00000017220	Fermitin family member 3.	Moesin.	0.579
FERMT3	PTPRC	ENSLACP00000019184	ENSLACP00000003518	Fermitin family member 3.	Protein tyrosine phosphatase receptor type C.	0.437
H2ZXZ3_LATCH	ITGA4	ENSLACP00000002264	ENSLACP00000016373	L-selectin; Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.	Integrin subunit alpha 4; Belongs to the integrin alpha chain family.	0.471
H2ZZU4_LATCH	LOC102349637	ENSLACP00000002915	ENSLACP00000022503	Selectin E.	Uncharacterized protein.	0.902
H3B5Z8_LATCH	ITGA4	ENSLACP00000017319	ENSLACP00000016373	Uncharacterized protein.	Integrin subunit alpha 4; Belongs to the integrin alpha chain family.	0.468
H3B5Z8_LATCH	LOC102347948	ENSLACP00000017319	ENSLACP00000001081	Uncharacterized protein.	Uncharacterized protein.	0.414
H3B5Z8_LATCH	LOC102365550	ENSLACP00000017319	ENSLACP00000021954	Uncharacterized protein.	Uncharacterized protein.	0.414
H3B5Z8_LATCH	PTPRC	ENSLACP00000017319	ENSLACP00000003518	Uncharacterized protein.	Protein tyrosine phosphatase receptor type C.	0.506
ITGA4	H2ZXZ3_LATCH	ENSLACP00000016373	ENSLACP00000002264	Integrin subunit alpha 4; Belongs to the integrin alpha chain family.	L-selectin; Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.	0.471
ITGA4	H3B5Z8_LATCH	ENSLACP00000016373	ENSLACP00000017319	Integrin subunit alpha 4; Belongs to the integrin alpha chain family.	Uncharacterized protein.	0.468
ITGA4	JAM2	ENSLACP00000016373	ENSLACP00000006697	Integrin subunit alpha 4; Belongs to the integrin alpha chain family.	Junctional adhesion molecule 2.	0.969
ITGA4	LOC102354417	ENSLACP00000016373	ENSLACP00000017459	Integrin subunit alpha 4; Belongs to the integrin alpha chain family.	Uncharacterized protein.	0.468
ITGA4	PTPRC	ENSLACP00000016373	ENSLACP00000003518	Integrin subunit alpha 4; Belongs to the integrin alpha chain family.	Protein tyrosine phosphatase receptor type C.	0.599
JAM2	ITGA4	ENSLACP00000006697	ENSLACP00000016373	Junctional adhesion molecule 2.	Integrin subunit alpha 4; Belongs to the integrin alpha chain family.	0.969
JAM2	LOC102347948	ENSLACP00000006697	ENSLACP00000001081	Junctional adhesion molecule 2.	Uncharacterized protein.	0.925
JAM2	LOC102365550	ENSLACP00000006697	ENSLACP00000021954	Junctional adhesion molecule 2.	Uncharacterized protein.	0.925
LOC102347948	H3B5Z8_LATCH	ENSLACP00000001081	ENSLACP00000017319	Uncharacterized protein.	Uncharacterized protein.	0.414