(46 nodes) I-kappaB kinase/NF-kappaB signaling network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TIRAP	TIR domain containing adaptor protein. (267 aa)
	H2ZS97_LATCH	TNF_2 domain-containing protein. (143 aa)
	IRAK1BP1	Interleukin 1 receptor associated kinase 1 binding protein 1. (167 aa)
	H2ZUT7_LATCH	TIR domain-containing protein. (1060 aa)
	H2ZV40_LATCH	Protein kinase domain-containing protein. (266 aa)
	NKIRAS1	NFKB inhibitor interacting Ras like 1. (191 aa)
	NFKBIL1	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1. (364 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (559 aa)
	CARD11	Caspase recruitment domain family member 11. (1137 aa)
	RIPK2	Receptor interacting serine/threonine kinase 2. (567 aa)
	TLR7	Toll-like receptor 7. (1033 aa)
	EDNRA	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (424 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (700 aa)
	TIFA	TRAF interacting protein with forkhead associated domain. (203 aa)
	LOC102358221	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (439 aa)
	H3AEV1_LATCH	TNF_2 domain-containing protein. (230 aa)
	TNFSF11	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (169 aa)
	H3AIP7_LATCH	Uncharacterized protein. (925 aa)
	REL	REL proto-oncogene, NF-kB subunit. (593 aa)
	NLRC3	NLR family CARD domain containing 3. (1005 aa)
	MAP3K14	Mitogen-activated protein kinase kinase kinase 14. (940 aa)
	MAP3K7	Mitogen-activated protein kinase kinase kinase 7. (580 aa)
	NOD2	Nucleotide binding oligomerization domain containing 2. (854 aa)
	AJUBA	Uncharacterized protein. (526 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (766 aa)
	TIFAB	TIFA inhibitor. (149 aa)
	H3AUI4_LATCH	Uncharacterized protein. (597 aa)
	FAIM	Fas apoptotic inhibitory molecule. (179 aa)
	EDNRB	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (440 aa)
	H3B111_LATCH	V-rel avian reticuloendotheliosis viral oncogene homolog A. (203 aa)
	ROCK1	Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1350 aa)
	H3B3L3_LATCH	NACHT domain-containing protein. (837 aa)
	NOD1	Nucleotide binding oligomerization domain containing 1. (830 aa)
	H3B6K7_LATCH	IKKbetaNEMObind domain-containing protein. (241 aa)
	ROCK2	Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1462 aa)
	EDN1	Endothelin 1. (216 aa)
	TLR8	Toll like receptor 8; Belongs to the Toll-like receptor family. (1016 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (286 aa)
	SNIP1	Smad nuclear interacting protein 1. (376 aa)
	AZI2	5-azacytidine induced 2. (394 aa)
	TBKBP1	TBK1 binding protein 1. (618 aa)
	NFKBIA	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b. (298 aa)
	CARD9	Caspase recruitment domain family member 9. (567 aa)
	TLR9	Toll-like receptor 9. (1039 aa)
	TANK	Uncharacterized protein. (72 aa)
	LOC102348796	Uncharacterized protein. (497 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AZI2	CHUK	ENSLACP00000019553	ENSLACP00000007128	5-azacytidine induced 2.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.577
AZI2	H3B6K7_LATCH	ENSLACP00000019553	ENSLACP00000017528	5-azacytidine induced 2.	IKKbetaNEMObind domain-containing protein.	0.577
AZI2	TANK	ENSLACP00000019553	ENSLACP00000023142	5-azacytidine induced 2.	Uncharacterized protein.	0.906
CARD11	CHUK	ENSLACP00000004229	ENSLACP00000007128	Caspase recruitment domain family member 11.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.757
CARD11	H3B111_LATCH	ENSLACP00000004229	ENSLACP00000015582	Caspase recruitment domain family member 11.	V-rel avian reticuloendotheliosis viral oncogene homolog A.	0.430
CARD11	H3B6K7_LATCH	ENSLACP00000004229	ENSLACP00000017528	Caspase recruitment domain family member 11.	IKKbetaNEMObind domain-containing protein.	0.761
CARD11	LOC102348796	ENSLACP00000004229	ENSLACP00000023619	Caspase recruitment domain family member 11.	Uncharacterized protein.	0.521
CARD11	MAP3K7	ENSLACP00000004229	ENSLACP00000011169	Caspase recruitment domain family member 11.	Mitogen-activated protein kinase kinase kinase 7.	0.805
CARD11	NFKBIA	ENSLACP00000004229	ENSLACP00000020134	Caspase recruitment domain family member 11.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b.	0.618
CARD11	REL	ENSLACP00000004229	ENSLACP00000009688	Caspase recruitment domain family member 11.	REL proto-oncogene, NF-kB subunit.	0.430
CARD11	RIPK2	ENSLACP00000004229	ENSLACP00000004499	Caspase recruitment domain family member 11.	Receptor interacting serine/threonine kinase 2.	0.521
CARD11	TRAF6	ENSLACP00000004229	ENSLACP00000003556	Caspase recruitment domain family member 11.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.833
CARD9	CHUK	ENSLACP00000020146	ENSLACP00000007128	Caspase recruitment domain family member 9.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.908
CARD9	LOC102348796	ENSLACP00000020146	ENSLACP00000023619	Caspase recruitment domain family member 9.	Uncharacterized protein.	0.936
CARD9	MYD88	ENSLACP00000020146	ENSLACP00000019094	Caspase recruitment domain family member 9.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.547
CARD9	NOD1	ENSLACP00000020146	ENSLACP00000016876	Caspase recruitment domain family member 9.	Nucleotide binding oligomerization domain containing 1.	0.613
CARD9	NOD2	ENSLACP00000020146	ENSLACP00000011767	Caspase recruitment domain family member 9.	Nucleotide binding oligomerization domain containing 2.	0.613
CARD9	RIPK2	ENSLACP00000020146	ENSLACP00000004499	Caspase recruitment domain family member 9.	Receptor interacting serine/threonine kinase 2.	0.936
CARD9	TRAF6	ENSLACP00000020146	ENSLACP00000003556	Caspase recruitment domain family member 9.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.437
CHUK	AZI2	ENSLACP00000007128	ENSLACP00000019553	Component of inhibitor of nuclear factor kappa B kinase complex.	5-azacytidine induced 2.	0.577