(13 nodes) Aromatic amino acid family catabolic process network (Latimeria chalumnae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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Predicted Interactions

gene neighborhood

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Your Input:
	GSTZ1	Glutathione S-transferase zeta 1; Belongs to the GST superfamily. (223 aa)
	QDPR	Quinoid dihydropteridine reductase. (241 aa)
	HGD	Homogentisate 1,2-dioxygenase. (459 aa)
	LOC102364955	4-hydroxyphenylpyruvate dioxygenase. (395 aa)
	AFMID	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. (293 aa)
	KYNU	Kynureninase. (278 aa)
	TAT	Tyrosine aminotransferase. (183 aa)
	HAAO	Uncharacterized protein. (252 aa)
	TDO2	Tryptophan 2,3-dioxygenase. (307 aa)
	IDO2	Indoleamine 2,3-dioxygenase 1. (425 aa)
	FAH	Fumarylacetoacetase. (348 aa)
	KMO	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. (474 aa)
	PAH	Phenylalanine hydroxylase. (335 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFMID	HAAO	ENSLACP00000020091	ENSLACP00000001313	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	Uncharacterized protein.	0.616
AFMID	IDO2	ENSLACP00000020091	ENSLACP00000003333	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	Indoleamine 2,3-dioxygenase 1.	0.950
AFMID	KMO	ENSLACP00000020091	ENSLACP00000009168	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	0.975
AFMID	KYNU	ENSLACP00000020091	ENSLACP00000023152	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	Kynureninase.	0.977
AFMID	TDO2	ENSLACP00000020091	ENSLACP00000000384	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	Tryptophan 2,3-dioxygenase.	0.982
FAH	GSTZ1	ENSLACP00000009155	ENSLACP00000015735	Fumarylacetoacetase.	Glutathione S-transferase zeta 1; Belongs to the GST superfamily.	0.998
FAH	HGD	ENSLACP00000009155	ENSLACP00000017066	Fumarylacetoacetase.	Homogentisate 1,2-dioxygenase.	0.943
FAH	KMO	ENSLACP00000009155	ENSLACP00000009168	Fumarylacetoacetase.	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	0.739
FAH	KYNU	ENSLACP00000009155	ENSLACP00000023152	Fumarylacetoacetase.	Kynureninase.	0.585
FAH	LOC102364955	ENSLACP00000009155	ENSLACP00000017328	Fumarylacetoacetase.	4-hydroxyphenylpyruvate dioxygenase.	0.860
FAH	PAH	ENSLACP00000009155	ENSLACP00000013379	Fumarylacetoacetase.	Phenylalanine hydroxylase.	0.422
FAH	TAT	ENSLACP00000009155	ENSLACP00000002468	Fumarylacetoacetase.	Tyrosine aminotransferase.	0.728
GSTZ1	FAH	ENSLACP00000015735	ENSLACP00000009155	Glutathione S-transferase zeta 1; Belongs to the GST superfamily.	Fumarylacetoacetase.	0.998
GSTZ1	HGD	ENSLACP00000015735	ENSLACP00000017066	Glutathione S-transferase zeta 1; Belongs to the GST superfamily.	Homogentisate 1,2-dioxygenase.	0.997
GSTZ1	LOC102364955	ENSLACP00000015735	ENSLACP00000017328	Glutathione S-transferase zeta 1; Belongs to the GST superfamily.	4-hydroxyphenylpyruvate dioxygenase.	0.708
GSTZ1	TAT	ENSLACP00000015735	ENSLACP00000002468	Glutathione S-transferase zeta 1; Belongs to the GST superfamily.	Tyrosine aminotransferase.	0.424
HAAO	AFMID	ENSLACP00000001313	ENSLACP00000020091	Uncharacterized protein.	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	0.616
HAAO	HGD	ENSLACP00000001313	ENSLACP00000017066	Uncharacterized protein.	Homogentisate 1,2-dioxygenase.	0.426
HAAO	IDO2	ENSLACP00000001313	ENSLACP00000003333	Uncharacterized protein.	Indoleamine 2,3-dioxygenase 1.	0.733
HAAO	KMO	ENSLACP00000001313	ENSLACP00000009168	Uncharacterized protein.	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	0.906