STRINGSTRING
LYN LYN LOC102362617 LOC102362617 DNER DNER ILK ILK CRB1 CRB1 PICK1 PICK1 NKX6-2 NKX6-2 NRROS NRROS H3AFZ1_LATCH H3AFZ1_LATCH DLL3 DLL3 CNP CNP DLL1 DLL1 C1QA C1QA CDK5 CDK5 LOC102367411 LOC102367411 H3AJR0_LATCH H3AJR0_LATCH ROR1 ROR1 LOC102362853 LOC102362853 SOX13 SOX13 NCSTN NCSTN MYOC MYOC MPP5 MPP5 NDRG1 NDRG1 LOC102367007 LOC102367007 NKX6-1 NKX6-1 LOC102348759 LOC102348759 PSEN1 PSEN1 B4GALT6 B4GALT6 STAT3 STAT3 EIF2B5 EIF2B5 SH3TC1 SH3TC1 ITGB4 ITGB4 GCM1 GCM1 ARHGEF10 ARHGEF10 EOMES EOMES NKX2-2 NKX2-2 NTRK2 NTRK2 SMO SMO METTL14 METTL14 DLX1 DLX1 PTPRZ1 PTPRZ1 PRDM8 PRDM8 WASF3 WASF3 PLPP3 PLPP3 APP APP DLX2 DLX2 ROR2 ROR2 H2ZTZ4_LATCH H2ZTZ4_LATCH ASPA ASPA EIF2B4 EIF2B4 H3B181_LATCH H3B181_LATCH PHGDH PHGDH CNTN2 CNTN2 METTL3 METTL3 ERCC2 ERCC2 DAG1 DAG1 ADAM22 ADAM22 FGF5 FGF5 METRN METRN LAMB2 LAMB2 PARD3 PARD3 CTNNB1 CTNNB1 PAX6 PAX6 GPR157 GPR157 H3B6N2_LATCH H3B6N2_LATCH ABL1 ABL1 NR2E1 NR2E1 DUSP10 DUSP10 ZNF488 ZNF488 H3B938_LATCH H3B938_LATCH GPR17 GPR17 PLP1 PLP1 PRX PRX TGFB1 TGFB1 EIF2B2 EIF2B2 TSPAN2 TSPAN2 MDK MDK SOX9 SOX9 NAB2 NAB2 MXRA8 MXRA8 CRB2 CRB2 MMP24 MMP24 VTN VTN RELN RELN CNTF CNTF GFAP GFAP SOX8 SOX8 NF1 NF1 EIF2B1 EIF2B1 SUZ12 SUZ12 B4GALT5 B4GALT5 LOC102356030 LOC102356030 CNTN1 CNTN1 GLI3 GLI3 LOC102356309 LOC102356309 TTC21B TTC21B H3A4P0_LATCH H3A4P0_LATCH TPPP TPPP SOX10 SOX10 SH3TC2 SH3TC2 PHOX2B PHOX2B LEF1 LEF1 MAG MAG H3A9H6_LATCH H3A9H6_LATCH ABL2 ABL2 CDKN2C CDKN2C
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LYNTyrosine-protein kinase. (515 aa)
LOC102362617Fatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (370 aa)
DNERDelta/notch like EGF repeat containing. (644 aa)
ILKIntegrin linked kinase. (417 aa)
CRB1Crumbs cell polarity complex component 1. (1366 aa)
PICK1Protein interacting with PRKCA 1. (409 aa)
NKX6-2NK6 homeobox 2. (278 aa)
NRROSNegative regulator of reactive oxygen species. (691 aa)
H3AFZ1_LATCHPeptidase S72 domain-containing protein. (633 aa)
DLL3Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (699 aa)
CNP2',3'-cyclic nucleotide 3' phosphodiesterase. (423 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
C1QAComplement C1q A chain. (241 aa)
CDK5Cyclin dependent kinase 5. (290 aa)
LOC102367411Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family. (334 aa)
H3AJR0_LATCHSRY-box transcription factor 13. (427 aa)
ROR1Receptor tyrosine kinase like orphan receptor 1. (769 aa)
LOC102362853Si:ch73-362m14.4. (500 aa)
SOX13Uncharacterized protein. (195 aa)
NCSTNNicastrin. (680 aa)
MYOCMyocilin. (272 aa)
MPP5Membrane palmitoylated protein 5; Belongs to the MAGUK family. (678 aa)
NDRG1N-myc downstream regulated 1. (402 aa)
LOC102367007Uncharacterized protein. (335 aa)
NKX6-1NK6 homeobox 1. (316 aa)
LOC102348759Si:dkey-96n2.3; Belongs to the G-protein coupled receptor 1 family. (322 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (465 aa)
B4GALT6Beta-1,4-galactosyltransferase 6. (387 aa)
STAT3Signal transducer and activator of transcription. (763 aa)
EIF2B5Eukaryotic translation initiation factor 2B subunit epsilon. (718 aa)
SH3TC1SH3 domain and tetratricopeptide repeats 1. (1263 aa)
ITGB4Integrin beta. (1787 aa)
GCM1Glial cells missing transcription factor 1. (443 aa)
ARHGEF10Rho guanine nucleotide exchange factor 10. (1338 aa)
EOMESEomesodermin. (419 aa)
NKX2-2NK2 homeobox 2. (278 aa)
NTRK2Tyrosine-protein kinase receptor. (819 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (820 aa)
METTL14Methyltransferase like 14; Belongs to the MT-A70-like family. (458 aa)
DLX1Distal-less homeobox 1. (253 aa)
PTPRZ1Protein tyrosine phosphatase receptor type Z1. (2273 aa)
PRDM8PR/SET domain 8. (576 aa)
WASF3WASP family member 3. (547 aa)
PLPP3Phospholipid phosphatase 3. (285 aa)
APPAmyloid beta precursor protein. (652 aa)
DLX2Distal-less homeobox 2. (278 aa)
ROR2Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (882 aa)
H2ZTZ4_LATCHFatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (363 aa)
ASPAAspartoacylase. (249 aa)
EIF2B4Eukaryotic translation initiation factor 2B subunit delta; Belongs to the eIF-2B alpha/beta/delta subunits family. (533 aa)
H3B181_LATCHTeneurin transmembrane protein 4. (1031 aa)
PHGDHPhosphoglycerate dehydrogenase. (522 aa)
CNTN2Contactin 2. (1026 aa)
METTL3Methyltransferase like 3; Belongs to the MT-A70-like family. (580 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (611 aa)
DAG1Dystroglycan 1. (900 aa)
ADAM22ADAM metallopeptidase domain 22. (728 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
METRNMeteorin, glial cell differentiation regulator. (310 aa)
LAMB2Laminin subunit beta 2. (1781 aa)
PARD3Par-3 family cell polarity regulator. (1214 aa)
CTNNB1Catenin beta 1. (781 aa)
PAX6Paired box 6. (463 aa)
GPR157G protein-coupled receptor 157. (333 aa)
H3B6N2_LATCHTeneurin N-terminal domain-containing protein. (214 aa)
ABL1Tyrosine-protein kinase. (1156 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (477 aa)
DUSP10Dual specificity phosphatase 10. (481 aa)
ZNF488PR domain containing 8. (528 aa)
H3B938_LATCHTeneurin N-terminal domain-containing protein. (181 aa)
GPR17G protein-coupled receptor 17; Belongs to the G-protein coupled receptor 1 family. (334 aa)
PLP1Proteolipid protein 1. (245 aa)
PRXPeriaxin. (1446 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
EIF2B2Eukaryotic translation initiation factor 2B subunit beta; Belongs to the eIF-2B alpha/beta/delta subunits family. (400 aa)
TSPAN2Tetraspanin. (221 aa)
MDKMidkine. (141 aa)
SOX9SRY-box transcription factor 9. (475 aa)
NAB2NGFI-A binding protein 2. (482 aa)
MXRA8Matrix remodeling associated 8. (436 aa)
CRB2Uncharacterized protein. (1473 aa)
MMP24Matrix metallopeptidase 24. (608 aa)
VTNVitronectin b. (492 aa)
RELNReelin. (3462 aa)
CNTFUncharacterized protein. (206 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (449 aa)
SOX8SRY-box transcription factor 8. (477 aa)
NF1Neurofibromin 1. (2814 aa)
EIF2B1Eukaryotic translation initiation factor 2B subunit alpha; Belongs to the eIF-2B alpha/beta/delta subunits family. (312 aa)
SUZ12SUZ12 polycomb repressive complex 2 subunit. (711 aa)
B4GALT5Beta-1,4-galactosyltransferase 5. (340 aa)
LOC102356030Uncharacterized protein. (313 aa)
CNTN1Contactin 1. (1009 aa)
GLI3GLI family zinc finger 3. (1456 aa)
LOC102356309Uncharacterized protein. (314 aa)
TTC21BTetratricopeptide repeat domain 21B. (1311 aa)
H3A4P0_LATCHIg-like domain-containing protein. (174 aa)
TPPPTubulin polymerization promoting protein. (227 aa)
SOX10SRY-box transcription factor 10. (451 aa)
SH3TC2SH3 domain and tetratricopeptide repeats 2. (1203 aa)
PHOX2BPaired like homeobox 2B. (287 aa)
LEF1Lymphoid enhancer binding factor 1. (397 aa)
MAGMyelin associated glycoprotein. (633 aa)
H3A9H6_LATCHFatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. (264 aa)
ABL2Tyrosine-protein kinase. (1175 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (169 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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