(60 nodes) Positive regulation of endothelial cell migration network (Latimeria chalumnae)

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second shell of interactors

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Predicted Interactions

gene neighborhood

gene fusions

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Your Input:
	ATP5F1A	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (553 aa)
	GPI	Glucose-6-phosphate isomerase; Belongs to the GPI family. (555 aa)
	ANXA3	Annexin. (323 aa)
	CCBE1	Collagen and calcium binding EGF domains 1. (357 aa)
	RIN2	Ras and Rab interactor 2. (902 aa)
	TSTA3	Tissue specific transplantation antigen P35B. (271 aa)
	LOC102358853	Uncharacterized protein. (577 aa)
	PLPP3	Phospholipid phosphatase 3. (285 aa)
	GPLD1	Glycosylphosphatidylinositol specific phospholipase D1. (835 aa)
	PDGFB	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (209 aa)
	ANGPT4	Angiopoietin 4. (491 aa)
	GATA3	GATA binding protein 3. (447 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	MET	MET proto-oncogene, receptor tyrosine kinase. (1385 aa)
	FGF18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
	LOC102360711	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (299 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1037 aa)
	ROCK2	Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1462 aa)
	EMC10	ER membrane protein complex subunit 10. (253 aa)
	BCAR1	BCAR1 scaffold protein, Cas family member. (914 aa)
	CD40	TNFR-Cys domain-containing protein. (167 aa)
	IGF2	Insulin like growth factor 2. (207 aa)
	NUS1	NUS1 dehydrodolichyl diphosphate synthase subunit. (276 aa)
	BSG	Basigin (Ok blood group). (368 aa)
	LOC102356182	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (196 aa)
	JCAD	Junctional cadherin 5 associated. (1240 aa)
	ATOH8	Atonal bHLH transcription factor 8. (279 aa)
	PIK3CG	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1106 aa)
	HSPB1	Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (219 aa)
	SIRT1	Sirtuin 1. (729 aa)
	ITGB1BP1	Integrin subunit beta 1 binding protein 1. (200 aa)
	NFE2L2	Nuclear factor, erythroid 2 like 2. (590 aa)
	PIK3CD	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1006 aa)
	ANGPT1	Angiopoietin 1. (499 aa)
	LOC102346566	Annexin. (343 aa)
	VEGFA	Vascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (189 aa)
	AAMP	Angio associated migratory cell protein. (434 aa)
	ATP5F1B	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (312 aa)
	ADAM17	ADAM metallopeptidase domain 17. (827 aa)
	H3AM01_LATCH	Integrin beta; Belongs to the integrin beta chain family. (769 aa)
	TEK	TEK receptor tyrosine kinase. (914 aa)
	KDR	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1339 aa)
	LOC102362971	Si:rp71-17i16.5; Belongs to the PI3/PI4-kinase family. (1081 aa)
	SP1	Sp1 transcription factor. (754 aa)
	MAP3K3	Mitogen-activated protein kinase kinase kinase 3. (658 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1077 aa)
	LGMN	Legumain. (436 aa)
	LOC102350357	Uncharacterized protein. (577 aa)
	VEGFC	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (410 aa)
	P2RX4	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (391 aa)
	FLT4	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1394 aa)
	AGT	SERPIN domain-containing protein; Belongs to the serpin family. (470 aa)
	NRP1	Neuropilin; Belongs to the neuropilin family. (928 aa)
	BCAS3	BCAS3 microtubule associated cell migration factor. (806 aa)
	CIB1	Calcium and integrin binding 1. (190 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	ZC3H12A	Zinc finger CCCH-type containing 12A. (600 aa)
	H3BEX6_LATCH	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (307 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
	THBS1	Thrombospondin 1. (1170 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGT	LOC102346566	ENSLACP00000023240	ENSLACP00000010172	SERPIN domain-containing protein; Belongs to the serpin family.	Annexin.	0.433
AGT	TGFB1	ENSLACP00000023240	ENSLACP00000020652	SERPIN domain-containing protein; Belongs to the serpin family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.555
ANGPT1	FLT4	ENSLACP00000010114	ENSLACP00000022811	Angiopoietin 1.	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.767
ANGPT1	KDR	ENSLACP00000010114	ENSLACP00000011126	Angiopoietin 1.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.798
ANGPT1	MET	ENSLACP00000010114	ENSLACP00000015263	Angiopoietin 1.	MET proto-oncogene, receptor tyrosine kinase.	0.673
ANGPT1	PIK3CD	ENSLACP00000010114	ENSLACP00000010097	Angiopoietin 1.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family.	0.593
ANGPT1	TEK	ENSLACP00000010114	ENSLACP00000011084	Angiopoietin 1.	TEK receptor tyrosine kinase.	0.985
ANGPT4	FLT4	ENSLACP00000003144	ENSLACP00000022811	Angiopoietin 4.	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.841
ANGPT4	KDR	ENSLACP00000003144	ENSLACP00000011126	Angiopoietin 4.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.798
ANGPT4	MET	ENSLACP00000003144	ENSLACP00000015263	Angiopoietin 4.	MET proto-oncogene, receptor tyrosine kinase.	0.673
ANGPT4	TEK	ENSLACP00000003144	ENSLACP00000011084	Angiopoietin 4.	TEK receptor tyrosine kinase.	0.985
ANXA3	LOC102346566	ENSLACP00000001048	ENSLACP00000010172	Annexin.	Annexin.	0.454
ATOH8	THBS1	ENSLACP00000007257	ENSLACP00000020712	Atonal bHLH transcription factor 8.	Thrombospondin 1.	0.410
ATP5F1A	ATP5F1B	ENSLACP00000000021	ENSLACP00000010603	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane.	0.999
ATP5F1A	GPI	ENSLACP00000000021	ENSLACP00000000902	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	Glucose-6-phosphate isomerase; Belongs to the GPI family.	0.871
ATP5F1B	ATP5F1A	ENSLACP00000010603	ENSLACP00000000021	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane.	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	0.999
ATP5F1B	GPI	ENSLACP00000010603	ENSLACP00000000902	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane.	Glucose-6-phosphate isomerase; Belongs to the GPI family.	0.714
ATP5F1B	HSPB1	ENSLACP00000010603	ENSLACP00000008229	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane.	Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family.	0.424
BCAR1	H3AM01_LATCH	ENSLACP00000003747	ENSLACP00000010672	BCAR1 scaffold protein, Cas family member.	Integrin beta; Belongs to the integrin beta chain family.	0.615
BCAR1	KDR	ENSLACP00000003747	ENSLACP00000011126	BCAR1 scaffold protein, Cas family member.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.474