STRINGSTRING
EVL EVL TGFBR2 TGFBR2 CARD10 CARD10 H3A3I5_LATCH H3A3I5_LATCH CD40 CD40 MCC MCC LOC102352804 LOC102352804 BCAR1 BCAR1 GATA3 GATA3 MMRN2 MMRN2 ANGPT4 ANGPT4 H2ZZY5_LATCH H2ZZY5_LATCH PDGFB PDGFB ARSJ ARSJ BMP10 BMP10 PTPRR PTPRR GLIPR2 GLIPR2 PIK3CG PIK3CG PLPP3 PLPP3 GLUL GLUL LOC102358853 LOC102358853 DCN DCN TSTA3 TSTA3 RIN2 RIN2 CCBE1 CCBE1 ANXA3 ANXA3 CSNK2B CSNK2B GPI GPI H2ZTT6_LATCH H2ZTT6_LATCH KRIT1 KRIT1 PTPN23 PTPN23 H2ZS97_LATCH H2ZS97_LATCH PTK2B PTK2B ATP5F1A ATP5F1A GPLD1 GPLD1 H3AEV1_LATCH H3AEV1_LATCH HSPB1 HSPB1 ENPP2 ENPP2 SIRT1 SIRT1 ITGB1BP1 ITGB1BP1 NFE2L2 NFE2L2 PIK3CD PIK3CD ANGPT1 ANGPT1 LOC102346566 LOC102346566 VEGFA VEGFA AAMP AAMP RREB1 RREB1 CAPN7 CAPN7 ATP5F1B ATP5F1B ADAM17 ADAM17 H3AM01_LATCH H3AM01_LATCH ANGPT2 ANGPT2 TEK TEK KDR KDR H3ANE5_LATCH H3ANE5_LATCH H3ANQ8_LATCH H3ANQ8_LATCH EFNA1 EFNA1 LOC102367007 LOC102367007 SYNJ2BP SYNJ2BP SLIT2 SLIT2 RAB25 RAB25 PTK2 PTK2 MECP2 MECP2 LOC102362971 LOC102362971 SPRED1 SPRED1 EPHA2 EPHA2 ATP2B4 ATP2B4 FBXW9 FBXW9 SP1 SP1 RGCC RGCC DLL4 DLL4 PDCD10 PDCD10 MAP3K3 MAP3K3 FGF4 FGF4 MAP2K5 MAP2K5 MMP9 MMP9 PIK3CB PIK3CB FGF1 FGF1 MET MET FGF18 FGF18 PTPRG PTPRG SEMA4A SEMA4A LOC102360711 LOC102360711 EPB41L5 EPB41L5 FGF7 FGF7 MEOX2 MEOX2 VASH1 VASH1 TBXA2R TBXA2R BMPR2 BMPR2 PTN PTN LOC102361837 LOC102361837 H3B752_LATCH H3B752_LATCH ARSI ARSI NR2E1 NR2E1 ROCK2 ROCK2 EMC10 EMC10 DUSP10 DUSP10 LOC102350357 LOC102350357 H3B8U3_LATCH H3B8U3_LATCH BCAS3 BCAS3 GDF2 GDF2 CIB1 CIB1 MTOR MTOR FGF2 FGF2 NF1 NF1 LOC102352268 LOC102352268 ZC3H12A ZC3H12A ARSB ARSB H3BEF8_LATCH H3BEF8_LATCH H3BES6_LATCH H3BES6_LATCH H3BEX6_LATCH H3BEX6_LATCH TGFB1 TGFB1 THBS1 THBS1 LOC102349333 LOC102349333 PLCG1 PLCG1 LGMN LGMN ACVRL1 ACVRL1 FBXW7 FBXW7 BMPER BMPER CLASP1 CLASP1 LOC102356233 LOC102356233 APOH APOH VEGFC VEGFC P2RX4 P2RX4 FLT4 FLT4 AGT AGT NRP1 NRP1 TGFB2 TGFB2 MAP4K4 MAP4K4 H3AD77_LATCH H3AD77_LATCH ATOH8 ATOH8 H3AC70_LATCH H3AC70_LATCH JCAD JCAD LOC102356182 LOC102356182 CTSH CTSH JUP JUP H3A964_LATCH H3A964_LATCH BSG BSG CLASP2 CLASP2 NUS1 NUS1 JUN JUN ARF6 ARF6 IGF2 IGF2
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EVLEnah/Vasp-like. (688 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (585 aa)
CARD10Caspase recruitment domain family member 10. (1063 aa)
H3A3I5_LATCHErythrocyte membrane protein band 4.1 like 4B. (325 aa)
CD40TNFR-Cys domain-containing protein. (167 aa)
MCCMCC regulator of WNT signaling pathway. (765 aa)
LOC102352804Phosphoinositide phospholipase C. (1172 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (914 aa)
GATA3GATA binding protein 3. (447 aa)
MMRN2Multimerin 2. (911 aa)
ANGPT4Angiopoietin 4. (491 aa)
H2ZZY5_LATCHUncharacterized protein. (548 aa)
PDGFBPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (209 aa)
ARSJArylsulfatase family member J. (468 aa)
BMP10Bone morphogenetic protein 10. (405 aa)
PTPRRProtein tyrosine phosphatase receptor type R. (330 aa)
GLIPR2GLI pathogenesis related 2; Belongs to the CRISP family. (153 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1106 aa)
PLPP3Phospholipid phosphatase 3. (285 aa)
GLULGlutamine synthetase. (408 aa)
LOC102358853Uncharacterized protein. (577 aa)
DCNDecorin; May affect the rate of fibrils formation. (353 aa)
TSTA3Tissue specific transplantation antigen P35B. (271 aa)
RIN2Ras and Rab interactor 2. (902 aa)
CCBE1Collagen and calcium binding EGF domains 1. (357 aa)
ANXA3Annexin. (323 aa)
CSNK2BCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (148 aa)
GPIGlucose-6-phosphate isomerase; Belongs to the GPI family. (555 aa)
H2ZTT6_LATCHPhosphoinositide phospholipase C. (404 aa)
KRIT1KRIT1 ankyrin repeat containing. (733 aa)
PTPN23Protein tyrosine phosphatase non-receptor type 23. (1414 aa)
H2ZS97_LATCHTNF_2 domain-containing protein. (143 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (876 aa)
ATP5F1AATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (553 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (835 aa)
H3AEV1_LATCHTNF_2 domain-containing protein. (230 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (219 aa)
ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase 2. (893 aa)
SIRT1Sirtuin 1. (729 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (200 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (590 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1006 aa)
ANGPT1Angiopoietin 1. (499 aa)
LOC102346566Annexin. (343 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (189 aa)
AAMPAngio associated migratory cell protein. (434 aa)
RREB1Ras responsive element binding protein 1. (1516 aa)
CAPN7Calpain 7; Belongs to the peptidase C2 family. (769 aa)
ATP5F1BATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (312 aa)
ADAM17ADAM metallopeptidase domain 17. (827 aa)
H3AM01_LATCHIntegrin beta; Belongs to the integrin beta chain family. (769 aa)
ANGPT2Angiopoietin 2. (493 aa)
TEKTEK receptor tyrosine kinase. (914 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1339 aa)
H3ANE5_LATCHBRO1 domain-containing protein. (170 aa)
H3ANQ8_LATCHMCC-bdg_PDZ domain-containing protein. (754 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (176 aa)
LOC102367007Uncharacterized protein. (335 aa)
SYNJ2BPPDZ domain-containing protein. (107 aa)
SLIT2Slit guidance ligand 2. (1372 aa)
RAB25RAB25, member RAS oncogene family. (214 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (673 aa)
MECP2Methyl-CpG binding protein 2. (459 aa)
LOC102362971Si:rp71-17i16.5; Belongs to the PI3/PI4-kinase family. (1081 aa)
SPRED1Sprouty related EVH1 domain containing 1. (446 aa)
EPHA2Uncharacterized protein. (979 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1233 aa)
FBXW9F-box and WD repeat domain containing 9. (465 aa)
SP1Sp1 transcription factor. (754 aa)
RGCCRegulator of cell cycle. (127 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (688 aa)
PDCD10Programmed cell death 10. (210 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (658 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (195 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
MMP9Matrix metallopeptidase 9. (682 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1077 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1385 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
PTPRGProtein tyrosine phosphatase receptor type G. (1221 aa)
SEMA4ASema domain-containing protein; Belongs to the semaphorin family. (758 aa)
LOC102360711PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (299 aa)
EPB41L5Erythrocyte membrane protein band 4.1 like 5. (506 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
MEOX2Mesenchyme homeobox 2. (295 aa)
VASH1Vasohibin 1. (363 aa)
TBXA2RThromboxane A2 receptor. (351 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1037 aa)
PTNPleiotrophin. (167 aa)
LOC102361837Glutamine synthetase. (370 aa)
H3B752_LATCHSulfatase domain-containing protein. (131 aa)
ARSIArylsulfatase family member I. (572 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (477 aa)
ROCK2Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1462 aa)
EMC10ER membrane protein complex subunit 10. (253 aa)
DUSP10Dual specificity phosphatase 10. (481 aa)
LOC102350357Uncharacterized protein. (577 aa)
H3B8U3_LATCHSerine/threonine-protein kinase TOR. (1418 aa)
BCAS3BCAS3 microtubule associated cell migration factor. (806 aa)
GDF2Growth differentiation factor 2. (431 aa)
CIB1Calcium and integrin binding 1. (190 aa)
MTORMechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family. (1009 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
NF1Neurofibromin 1. (2814 aa)
LOC102352268Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (600 aa)
ARSBArylsulfatase B. (532 aa)
H3BEF8_LATCHCytoplasmic linker associated protein 1a. (1413 aa)
H3BES6_LATCHAngiopoietin 2b. (498 aa)
H3BEX6_LATCHReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (307 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
THBS1Thrombospondin 1. (1170 aa)
LOC102349333Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (176 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1219 aa)
LGMNLegumain. (436 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (497 aa)
FBXW7F-box and WD repeat domain containing 7. (713 aa)
BMPERBMP binding endothelial regulator. (682 aa)
CLASP1Uncharacterized protein. (66 aa)
LOC102356233TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (574 aa)
APOHApolipoprotein H. (351 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (410 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (391 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1394 aa)
AGTSERPIN domain-containing protein; Belongs to the serpin family. (470 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (928 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
MAP4K4Mitogen-activated protein kinase kinase kinase kinase 4. (1139 aa)
H3AD77_LATCHJunE proto-oncogene, AP-1 transcription factor subunit. (316 aa)
ATOH8Atonal bHLH transcription factor 8. (279 aa)
H3AC70_LATCHLRRNT domain-containing protein. (132 aa)
JCADJunctional cadherin 5 associated. (1240 aa)
LOC102356182Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (196 aa)
CTSHCathepsin H; Belongs to the peptidase C1 family. (329 aa)
JUPJunction plakoglobin. (694 aa)
H3A964_LATCHSi:ch211-191a24.4. (218 aa)
BSGBasigin (Ok blood group). (368 aa)
CLASP2Cytoplasmic linker associated protein 2. (1303 aa)
NUS1NUS1 dehydrodolichyl diphosphate synthase subunit. (276 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (311 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
IGF2Insulin like growth factor 2. (207 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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