STRINGSTRING
MYOCD MYOCD MAP2K4 MAP2K4 APOH APOH AMBRA1 AMBRA1 MDK MDK LRP6 LRP6 TIGAR TIGAR TP53 TP53 PDCD4 PDCD4 ATG5 ATG5 BAG3 BAG3 DNMT1 DNMT1 NFE2L2 NFE2L2 RGL2 RGL2 GRIA4 GRIA4 SIRT1 SIRT1 SFRP2 SFRP2 KIFAP3 KIFAP3 MFN2 MFN2 FNDC1 FNDC1 HAND2 HAND2 ATF4 ATF4 DIPK2A DIPK2A ZC3H12A ZC3H12A SOD2 SOD2 E2F3 E2F3 NKX2-5 NKX2-5 H3B4J4_LATCH H3B4J4_LATCH SLC7A5 SLC7A5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MYOCDMyocardin. (963 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (463 aa)
APOHApolipoprotein H. (351 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1195 aa)
MDKMidkine. (141 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1615 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (212 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (401 aa)
PDCD4Programmed cell death 4. (466 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
BAG3BCL2 associated athanogene 3. (561 aa)
DNMT1DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1273 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (590 aa)
RGL2Uncharacterized protein. (665 aa)
GRIA4Glutamate ionotropic receptor AMPA type subunit 4. (903 aa)
SIRT1Sirtuin 1. (729 aa)
SFRP2Secreted frizzled related protein 2. (294 aa)
KIFAP3Kinesin associated protein 3. (795 aa)
MFN2Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
FNDC1Uncharacterized protein. (1670 aa)
HAND2Heart and neural crest derivatives expressed 2. (210 aa)
ATF4Activating transcription factor 4. (374 aa)
DIPK2ADivergent protein kinase domain 2A. (434 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (600 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (223 aa)
E2F3E2F transcription factor 3. (340 aa)
NKX2-5NK2 homeobox 5. (296 aa)
H3B4J4_LATCHUncharacterized protein. (982 aa)
SLC7A5Solute carrier family 7 member 5. (522 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
Server load: low (30%) [HD]