STRINGSTRING
NKX2-5 NKX2-5 TIGAR TIGAR MDK MDK AMBRA1 AMBRA1 HAND2 HAND2 FNDC1 FNDC1 KIFAP3 KIFAP3 SFRP2 SFRP2 RGL2 RGL2 NFE2L2 NFE2L2 ATG5 ATG5 TP53 TP53 MYOCD MYOCD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NKX2-5NK2 homeobox 5. (296 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (212 aa)
MDKMidkine. (141 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1195 aa)
HAND2Heart and neural crest derivatives expressed 2. (210 aa)
FNDC1Uncharacterized protein. (1670 aa)
KIFAP3Kinesin associated protein 3. (795 aa)
SFRP2Secreted frizzled related protein 2. (294 aa)
RGL2Uncharacterized protein. (665 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (590 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (401 aa)
MYOCDMyocardin. (963 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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