STRINGSTRING
H3BE69_LATCH H3BE69_LATCH JAG1 JAG1 H2ZWA9_LATCH H2ZWA9_LATCH LRG1 LRG1 GLIPR2 GLIPR2 GATA3 GATA3 TGFBR2 TGFBR2 LEF1 LEF1 CLASP2 CLASP2 TRIM62 TRIM62 SMAD7 SMAD7 GREM1 GREM1 POFUT2 POFUT2 SDHAF2 SDHAF2 SFRP2 SFRP2 TGFB2 TGFB2 ZNF750 ZNF750 BAMBI BAMBI TGFBR1 TGFBR1 SMAD2 SMAD2 H3AFZ1_LATCH H3AFZ1_LATCH LOC102351081 LOC102351081 SMAD4 SMAD4 IL6 IL6 IL17RD IL17RD ACVR1 ACVR1 EFNA1 EFNA1 PHLDB2 PHLDB2 SMAD3 SMAD3 TBX20 TBX20 SPRED1 SPRED1 LOXL2 LOXL2 RGCC RGCC H3AVL9_LATCH H3AVL9_LATCH H3AX34_LATCH H3AX34_LATCH DAB2 DAB2 HPN HPN LOC102356668 LOC102356668 BMP2 BMP2 DAG1 DAG1 MCRIP1 MCRIP1 CTNNB1 CTNNB1 SPRY1 SPRY1 H3B8U3_LATCH H3B8U3_LATCH MTOR MTOR TGFB3 TGFB3 PHLDB1 PHLDB1 LOC102352268 LOC102352268 BCL9L BCL9L H3BEF8_LATCH H3BEF8_LATCH TGFB1 TGFB1 SPRED3 SPRED3 MDK MDK BMP4 BMP4 LOC102358988 LOC102358988 CLASP1 CLASP1 ENG ENG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
H3BE69_LATCHPID domain-containing protein. (136 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1220 aa)
H2ZWA9_LATCHUncharacterized protein. (145 aa)
LRG1LRRCT domain-containing protein. (337 aa)
GLIPR2GLI pathogenesis related 2; Belongs to the CRISP family. (153 aa)
GATA3GATA binding protein 3. (447 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (585 aa)
LEF1Lymphoid enhancer binding factor 1. (397 aa)
CLASP2Cytoplasmic linker associated protein 2. (1303 aa)
TRIM62B30.2/SPRY domain-containing protein. (312 aa)
SMAD7Mothers against decapentaplegic homolog. (377 aa)
GREM1Gremlin 1, DAN family BMP antagonist. (189 aa)
POFUT2Protein O-fucosyltransferase 2. (441 aa)
SDHAF2Succinate dehydrogenase assembly factor 2, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. (166 aa)
SFRP2Secreted frizzled related protein 2. (294 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
ZNF750Zinc finger protein 750. (722 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (259 aa)
TGFBR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
H3AFZ1_LATCHPeptidase S72 domain-containing protein. (633 aa)
LOC102351081Bone morphogenetic protein 16. (396 aa)
SMAD4MH2 domain-containing protein. (412 aa)
IL6Uncharacterized protein. (149 aa)
IL17RDInterleukin 17 receptor D. (698 aa)
ACVR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (176 aa)
PHLDB2Pleckstrin homology like domain family B member 2. (536 aa)
SMAD3Mothers against decapentaplegic homolog. (358 aa)
TBX20T-box transcription factor 20. (441 aa)
SPRED1Sprouty related EVH1 domain containing 1. (446 aa)
LOXL2Lysyl oxidase like 2. (773 aa)
RGCCRegulator of cell cycle. (127 aa)
H3AVL9_LATCHLysyl oxidase-like 3b. (475 aa)
H3AX34_LATCHEph LBD domain-containing protein. (241 aa)
DAB2DAB adaptor protein 2. (745 aa)
HPNHepsin; Belongs to the peptidase S1 family. (415 aa)
LOC102356668Uncharacterized protein. (671 aa)
BMP2Bone morphogenetic protein 2. (402 aa)
DAG1Dystroglycan 1. (900 aa)
MCRIP1MAPK regulated corepressor interacting protein 1. (109 aa)
CTNNB1Catenin beta 1. (781 aa)
SPRY1Sprouty RTK signaling antagonist 1. (320 aa)
H3B8U3_LATCHSerine/threonine-protein kinase TOR. (1418 aa)
MTORMechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family. (1009 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (409 aa)
PHLDB1Pleckstrin homology like domain family B member 1. (1408 aa)
LOC102352268Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
BCL9LBCL9 like. (1514 aa)
H3BEF8_LATCHCytoplasmic linker associated protein 1a. (1413 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
SPRED3Sprouty related EVH1 domain containing 3. (453 aa)
MDKMidkine. (141 aa)
BMP4Bone morphogenetic protein 4. (460 aa)
LOC102358988Mothers against decapentaplegic homolog. (614 aa)
CLASP1Uncharacterized protein. (66 aa)
ENGEndoglin. (674 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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