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ENG ENG LOC102356233 LOC102356233 LOC102358988 LOC102358988 ACVRL1 ACVRL1 BMP4 BMP4 LOC102355877 LOC102355877 LOC102355609 LOC102355609 TGFB1 TGFB1 H3BEX6_LATCH H3BEX6_LATCH H3BE69_LATCH H3BE69_LATCH BMP7 BMP7 LOC102352268 LOC102352268 TGFB3 TGFB3 GDF10 GDF10 GDF2 GDF2 H3B924_LATCH H3B924_LATCH NODAL NODAL INHBB INHBB INHA INHA BMPR2 BMPR2 GDF3 GDF3 BMP2 BMP2 BMP15 BMP15 DAB2 DAB2 LOC102358054 LOC102358054 BMP6 BMP6 ACVR1 ACVR1 GDF5 GDF5 TWSG1 TWSG1 LOC102357009 LOC102357009 SMAD4 SMAD4 LOC102351081 LOC102351081 TGFBR1 TGFBR1 TGFB2 TGFB2 GDF6 GDF6 GDF7 GDF7 INHBA INHBA LOC102356523 LOC102356523 TGFBR2 TGFBR2 BMP10 BMP10 BMP3 BMP3 LOC102351518 LOC102351518 CSNK2B CSNK2B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENGEndoglin. (674 aa)
LOC102356233TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (574 aa)
LOC102358988Mothers against decapentaplegic homolog. (614 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (497 aa)
BMP4Bone morphogenetic protein 4. (460 aa)
LOC102355877TGF_BETA_2 domain-containing protein. (359 aa)
LOC102355609TGF_BETA_2 domain-containing protein. (385 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
H3BEX6_LATCHReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (307 aa)
H3BE69_LATCHPID domain-containing protein. (136 aa)
BMP7Bone morphogenetic protein 7. (425 aa)
LOC102352268Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (409 aa)
GDF10Growth differentiation factor 10. (440 aa)
GDF2Growth differentiation factor 2. (431 aa)
H3B924_LATCHTGF_BETA_2 domain-containing protein. (356 aa)
NODALTGF_BETA_2 domain-containing protein. (409 aa)
INHBBInhibin subunit beta B. (393 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (345 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1037 aa)
GDF3Growth differentiation factor 3. (381 aa)
BMP2Bone morphogenetic protein 2. (402 aa)
BMP15Bone morphogenetic protein 15. (394 aa)
DAB2DAB adaptor protein 2. (745 aa)
LOC102358054Bone morphogenetic protein 8a. (420 aa)
BMP6Bone morphogenetic protein 6. (428 aa)
ACVR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
GDF5Growth differentiation factor 5. (501 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (220 aa)
LOC102357009Southpaw. (414 aa)
SMAD4MH2 domain-containing protein. (412 aa)
LOC102351081Bone morphogenetic protein 16. (396 aa)
TGFBR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
GDF6Growth differentiation factor 6a. (408 aa)
GDF7Growth differentiation factor 7. (416 aa)
INHBAInhibin subunit beta A. (390 aa)
LOC102356523Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (510 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (585 aa)
BMP10Bone morphogenetic protein 10. (405 aa)
BMP3Bone morphogenetic protein 3. (365 aa)
LOC102351518Left-right determination factor. (364 aa)
CSNK2BCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (148 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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