(26 nodes) Regulation of macrophage cytokine production network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102348796	Uncharacterized protein. (497 aa)
	LOC102366847	Uncharacterized protein; Belongs to the semaphorin family. (542 aa)
	RIPK2	Receptor interacting serine/threonine kinase 2. (567 aa)
	PANX1	Pannexin; Structural component of the gap junctions and the hemichannels. (428 aa)
	MAPKAPK2	MAPK activated protein kinase 2. (332 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
	SIRT1	Sirtuin 1. (729 aa)
	LOC102349920	Uncharacterized protein. (199 aa)
	UBE2J1	Ubiquitin conjugating enzyme E2 J1. (321 aa)
	NOD2	Nucleotide binding oligomerization domain containing 2. (854 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (766 aa)
	H3B3L3_LATCH	NACHT domain-containing protein. (837 aa)
	NOD1	Nucleotide binding oligomerization domain containing 1. (830 aa)
	SPON2	Spondin 2. (333 aa)
	CD74	CD74 molecule. (279 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (409 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (286 aa)
	CUEDC2	CUE domain containing 2. (154 aa)
	IRAK3	Interleukin 1 receptor associated kinase 3. (546 aa)
	LOC102352268	Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
	LOC102365809	Si:ch211-113g11.6; Belongs to the semaphorin family. (631 aa)
	CARD9	Caspase recruitment domain family member 9. (567 aa)
	NLRX1	NLR family member X1. (855 aa)
	AXL	AXL receptor tyrosine kinase. (872 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
	LOC102366586	Sema domain-containing protein; Belongs to the semaphorin family. (620 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CARD9	LOC102348796	ENSLACP00000020146	ENSLACP00000023619	Caspase recruitment domain family member 9.	Uncharacterized protein.	0.936
CARD9	MYD88	ENSLACP00000020146	ENSLACP00000019094	Caspase recruitment domain family member 9.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.547
CARD9	NOD1	ENSLACP00000020146	ENSLACP00000016876	Caspase recruitment domain family member 9.	Nucleotide binding oligomerization domain containing 1.	0.613
CARD9	NOD2	ENSLACP00000020146	ENSLACP00000011767	Caspase recruitment domain family member 9.	Nucleotide binding oligomerization domain containing 2.	0.613
CARD9	RIPK2	ENSLACP00000020146	ENSLACP00000004499	Caspase recruitment domain family member 9.	Receptor interacting serine/threonine kinase 2.	0.936
H3B3L3_LATCH	LOC102348796	ENSLACP00000016484	ENSLACP00000023619	NACHT domain-containing protein.	Uncharacterized protein.	0.974
H3B3L3_LATCH	NOD1	ENSLACP00000016484	ENSLACP00000016876	NACHT domain-containing protein.	Nucleotide binding oligomerization domain containing 1.	0.902
H3B3L3_LATCH	RIPK2	ENSLACP00000016484	ENSLACP00000004499	NACHT domain-containing protein.	Receptor interacting serine/threonine kinase 2.	0.980
IRAK3	MYD88	ENSLACP00000001550	ENSLACP00000019094	Interleukin 1 receptor associated kinase 3.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.802
IRAK3	TLR3	ENSLACP00000001550	ENSLACP00000012956	Interleukin 1 receptor associated kinase 3.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.439
LOC102348796	CARD9	ENSLACP00000023619	ENSLACP00000020146	Uncharacterized protein.	Caspase recruitment domain family member 9.	0.936
LOC102348796	H3B3L3_LATCH	ENSLACP00000023619	ENSLACP00000016484	Uncharacterized protein.	NACHT domain-containing protein.	0.974
LOC102348796	MYD88	ENSLACP00000023619	ENSLACP00000019094	Uncharacterized protein.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.424
LOC102348796	NOD1	ENSLACP00000023619	ENSLACP00000016876	Uncharacterized protein.	Nucleotide binding oligomerization domain containing 1.	0.981
LOC102348796	NOD2	ENSLACP00000023619	ENSLACP00000011767	Uncharacterized protein.	Nucleotide binding oligomerization domain containing 2.	0.980
LOC102348796	RIPK2	ENSLACP00000023619	ENSLACP00000004499	Uncharacterized protein.	Receptor interacting serine/threonine kinase 2.	0.900
LOC102349920	MYD88	ENSLACP00000010067	ENSLACP00000019094	Uncharacterized protein.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.522
LOC102352268	TGFB1	ENSLACP00000019574	ENSLACP00000020652	Transforming growth factor beta; Belongs to the TGF-beta family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.693
LOC102352268	TGFB2	ENSLACP00000019574	ENSLACP00000007733	Transforming growth factor beta; Belongs to the TGF-beta family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.901
LOC102352268	TGFB3	ENSLACP00000019574	ENSLACP00000018912	Transforming growth factor beta; Belongs to the TGF-beta family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.964