(117 nodes) Negative regulation of endopeptidase activity network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	H3AD83_LATCH	Uncharacterized protein. (1429 aa)
	M3XLM0_LATCH	SERPIN domain-containing protein; Belongs to the serpin family. (407 aa)
	LOC102347835	SERPIN domain-containing protein; Belongs to the serpin family. (380 aa)
	M3XL62_LATCH	Uncharacterized protein. (269 aa)
	HGF	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (720 aa)
	AGT	SERPIN domain-containing protein; Belongs to the serpin family. (470 aa)
	FETUB	Fetuin B. (486 aa)
	UBE2O	Ubiquitin conjugating enzyme E2 O. (1313 aa)
	LOC102351715	Uncharacterized protein. (1426 aa)
	M3XHZ7_LATCH	Uncharacterized protein. (120 aa)
	LOC106706381	Uncharacterized protein. (224 aa)
	ITIH2	Inter-alpha-trypsin inhibitor heavy chain 2. (979 aa)
	LOC102365046	SERPIN domain-containing protein; Belongs to the serpin family. (250 aa)
	VTN	Vitronectin b. (492 aa)
	NR4A1	Nuclear receptor subfamily 4 group A member 1. (580 aa)
	CRYAB	Crystallin alpha B; Belongs to the small heat shock protein (HSP20) family. (173 aa)
	WFDC3	WAP four-disulfide core domain 2. (167 aa)
	NGF	Nerve growth factor; Belongs to the NGF-beta family. (272 aa)
	RFFL	Ring finger and FYVE-like domain containing E3 ubiquitin protein ligase. (361 aa)
	RNF34	Ring finger protein 34. (384 aa)
	LAMTOR5	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5. (92 aa)
	THBS1	Thrombospondin 1. (1170 aa)
	APLP2	Amyloid beta precursor like protein 2. (732 aa)
	PRDX5	Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. (190 aa)
	CRIM1	Cysteine rich transmembrane BMP regulator 1. (881 aa)
	AHSG	Alpha 2-HS glycoprotein. (252 aa)
	BIRC5	Baculoviral IAP repeat containing 5. (139 aa)
	FAM124B	Family with sequence similarity 124 member B. (513 aa)
	TNFSF14	TNF_2 domain-containing protein. (238 aa)
	PEBP1	Phosphatidylethanolamine binding protein 1. (187 aa)
	LOC102356199	Uncharacterized protein. (1657 aa)
	XIAP	X-linked inhibitor of apoptosis. (606 aa)
	TIMP2	TIMP metallopeptidase inhibitor 2. (221 aa)
	UBE2Z	Ubiquitin conjugating enzyme E2 Z. (379 aa)
	C3	Uncharacterized protein. (1286 aa)
	H3B8U4_LATCH	Uncharacterized protein. (74 aa)
	SERPINC1	Serpin family C member 1; Belongs to the serpin family. (485 aa)
	BIRC6	Baculoviral IAP repeat containing 6. (4819 aa)
	H3B780_LATCH	Uncharacterized protein. (370 aa)
	USP14	Ubiquitin carboxyl-terminal hydrolase. (490 aa)
	PRDX3	Peroxiredoxin 3. (254 aa)
	TIMP3	TIMP metallopeptidase inhibitor 3. (216 aa)
	WFIKKN1	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1. (556 aa)
	GAS6	Uncharacterized protein. (681 aa)
	ROCK1	Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1350 aa)
	SPOCK3	SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3. (194 aa)
	H3B1U1_LATCH	RING-type domain-containing protein. (527 aa)
	LOC102346391	Uncharacterized protein. (1606 aa)
	CDKN2D	Cyclin dependent kinase inhibitor 2D. (168 aa)
	MMP9	Matrix metallopeptidase 9. (682 aa)
	PIH1D1	Uncharacterized protein. (294 aa)
	MAP2K5	Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
	RARRES1	Retinoic acid receptor responder 1. (270 aa)
	SERPINI1	Serpin family I member 1; Belongs to the serpin family. (409 aa)
	LXN	Latexin. (234 aa)
	NAIP	NLR family apoptosis inhibitory protein. (1422 aa)
	C5	Complement C5. (1691 aa)
	SERPINI2	Serpin family I member 2; Belongs to the serpin family. (414 aa)
	INTS1	Integrator complex subunit 1. (2183 aa)
	LOC102346472	Uncharacterized protein. (168 aa)
	TIMP4	TIMP metallopeptidase inhibitor 4. (222 aa)
	SORL1	Sortilin-related receptor, L(DLR class) A repeats containing. (1410 aa)
	LOC102348351	SERPIN domain-containing protein; Belongs to the serpin family. (453 aa)
	ITIH5	Inter-alpha-trypsin inhibitor heavy chain 5. (904 aa)
	COL28A1	Collagen, type XXVIII, alpha 2a. (1220 aa)
	SH3RF1	SH3 domain containing ring finger 1. (745 aa)
	SERPIND1	Serpin family D member 1; Belongs to the serpin family. (538 aa)
	USP47	Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1381 aa)
	H3AM54_LATCH	Uncharacterized protein. (972 aa)
	PAPLN	Papilin, proteoglycan like sulfated glycoprotein. (1221 aa)
	ITIH6	Inter-alpha-trypsin inhibitor heavy chain family member 6. (1027 aa)
	PSMF1	Proteasome inhibitor subunit 1. (265 aa)
	SERPINA10	Serpin family A member 10; Belongs to the serpin family. (427 aa)
	PTGS2	Prostaglandin-endoperoxide synthase 2. (620 aa)
	LOC102351431	Uncharacterized protein. (229 aa)
	LOC102349826	Cystatin domain-containing protein; Belongs to the cystatin family. (141 aa)
	RECK	Reversion inducing cysteine rich protein with kazal motifs. (952 aa)
	FAM124A	Family with sequence similarity 124 member A. (526 aa)
	UCHL5	Ubiquitin carboxyl-terminal hydrolase. (329 aa)
	H3AEV1_LATCH	TNF_2 domain-containing protein. (230 aa)
	H3AEK5_LATCH	Aquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (268 aa)
	CD109	CD109 molecule. (1429 aa)
	LTA	Lymphotoxin alpha. (166 aa)
	SERPINH1	Serpin family H member 1; Belongs to the serpin family. (405 aa)
	DHCR24	24-dehydrocholesterol reductase. (516 aa)
	SFRP2	Secreted frizzled related protein 2. (294 aa)
	ANOS1	Anosmin 1. (596 aa)
	SERPINE1	Serpin family E member 1; Belongs to the serpin family. (403 aa)
	SERPINE3	Serpin family E member 3; Belongs to the serpin family. (417 aa)
	SERPINE2	Serpin family E member 2; Belongs to the serpin family. (403 aa)
	WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2. (575 aa)
	NLE1	Notchless homolog 1. (488 aa)
	LOC102361240	A2M_recep domain-containing protein. (601 aa)
	PAK2	Non-specific serine/threonine protein kinase. (521 aa)
	LOC102352454	Uncharacterized protein. (1440 aa)
	H3A4G6_LATCH	ITI_HC_C domain-containing protein. (311 aa)
	H3A420_LATCH	Uncharacterized protein. (1269 aa)
	H3A3Z8_LATCH	SERPIN domain-containing protein; Belongs to the serpin family. (332 aa)
	H3A3F5_LATCH	SERPIN domain-containing protein; Belongs to the serpin family. (325 aa)
	PCID2	PCI domain containing 2. (452 aa)
	SERPINF2	Serpin family F member 2; Belongs to the serpin family. (394 aa)
	SERPINA1	SERPIN domain-containing protein; Belongs to the serpin family. (418 aa)
	AMBP	Alpha-1-microglobulin/bikunin precursor. (350 aa)
	TNFAIP8	TNF alpha induced protein 8. (198 aa)
	CST7	Cystatin F. (139 aa)
	H2ZYY1_LATCH	SERPIN domain-containing protein; Belongs to the serpin family. (430 aa)
	SERPINF1	Serpin family F member 1; Belongs to the serpin family. (420 aa)
	FNIP1	Folliculin interacting protein 1. (1156 aa)
	H2ZY64_LATCH	A2M_N_2 domain-containing protein. (594 aa)
	LOC102361064	NTR domain-containing protein. (202 aa)
	APP	Amyloid beta precursor protein. (652 aa)
	CAAP1	Caspase activity and apoptosis inhibitor 1. (295 aa)
	FABP1	Fatty acid binding protein 1. (98 aa)
	BIRC2	Baculoviral IAP repeat containing 2. (616 aa)
	H2ZT71_LATCH	Uncharacterized protein. (140 aa)
	H2ZS97_LATCH	TNF_2 domain-containing protein. (143 aa)
	LOC102356340	Uncharacterized protein. (667 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGT	AHSG	ENSLACP00000023240	ENSLACP00000020153	SERPIN domain-containing protein; Belongs to the serpin family.	Alpha 2-HS glycoprotein.	0.412
AGT	AMBP	ENSLACP00000023240	ENSLACP00000003553	SERPIN domain-containing protein; Belongs to the serpin family.	Alpha-1-microglobulin/bikunin precursor.	0.480
AGT	APP	ENSLACP00000023240	ENSLACP00000001643	SERPIN domain-containing protein; Belongs to the serpin family.	Amyloid beta precursor protein.	0.514
AGT	C3	ENSLACP00000023240	ENSLACP00000018425	SERPIN domain-containing protein; Belongs to the serpin family.	Uncharacterized protein.	0.418
AGT	C5	ENSLACP00000023240	ENSLACP00000014054	SERPIN domain-containing protein; Belongs to the serpin family.	Complement C5.	0.627
AGT	LOC102346391	ENSLACP00000023240	ENSLACP00000015820	SERPIN domain-containing protein; Belongs to the serpin family.	Uncharacterized protein.	0.418
AGT	LOC102356199	ENSLACP00000023240	ENSLACP00000018716	SERPIN domain-containing protein; Belongs to the serpin family.	Uncharacterized protein.	0.418
AGT	MMP9	ENSLACP00000023240	ENSLACP00000014693	SERPIN domain-containing protein; Belongs to the serpin family.	Matrix metallopeptidase 9.	0.476
AGT	SERPINC1	ENSLACP00000023240	ENSLACP00000018195	SERPIN domain-containing protein; Belongs to the serpin family.	Serpin family C member 1; Belongs to the serpin family.	0.582
AGT	SERPIND1	ENSLACP00000023240	ENSLACP00000011889	SERPIN domain-containing protein; Belongs to the serpin family.	Serpin family D member 1; Belongs to the serpin family.	0.415
AGT	SERPINE1	ENSLACP00000023240	ENSLACP00000006192	SERPIN domain-containing protein; Belongs to the serpin family.	Serpin family E member 1; Belongs to the serpin family.	0.535
AGT	SERPINE2	ENSLACP00000023240	ENSLACP00000005293	SERPIN domain-containing protein; Belongs to the serpin family.	Serpin family E member 2; Belongs to the serpin family.	0.426
AGT	TIMP2	ENSLACP00000023240	ENSLACP00000018630	SERPIN domain-containing protein; Belongs to the serpin family.	TIMP metallopeptidase inhibitor 2.	0.447
AHSG	AGT	ENSLACP00000020153	ENSLACP00000023240	Alpha 2-HS glycoprotein.	SERPIN domain-containing protein; Belongs to the serpin family.	0.412
AHSG	AMBP	ENSLACP00000020153	ENSLACP00000003553	Alpha 2-HS glycoprotein.	Alpha-1-microglobulin/bikunin precursor.	0.907
AHSG	FABP1	ENSLACP00000020153	ENSLACP00000000844	Alpha 2-HS glycoprotein.	Fatty acid binding protein 1.	0.840
AHSG	ITIH2	ENSLACP00000020153	ENSLACP00000022268	Alpha 2-HS glycoprotein.	Inter-alpha-trypsin inhibitor heavy chain 2.	0.538
AHSG	LOC102351715	ENSLACP00000020153	ENSLACP00000022402	Alpha 2-HS glycoprotein.	Uncharacterized protein.	0.423
AHSG	SERPINA1	ENSLACP00000020153	ENSLACP00000003590	Alpha 2-HS glycoprotein.	SERPIN domain-containing protein; Belongs to the serpin family.	0.531
AHSG	SERPINA10	ENSLACP00000020153	ENSLACP00000009356	Alpha 2-HS glycoprotein.	Serpin family A member 10; Belongs to the serpin family.	0.502