STRINGSTRING
LOC102360711 LOC102360711 NF2 NF2 H2ZSK8_LATCH H2ZSK8_LATCH SHANK3 SHANK3 EPM2A EPM2A RB1 RB1 LEPR LEPR AREG AREG ORC3 ORC3 MECP2 MECP2 VEGFC VEGFC LOC102356247 LOC102356247 LOC102355265 LOC102355265 NF1 NF1 CSF1R CSF1R TP53 TP53 GFAP GFAP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC102360711PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (299 aa)
NF2Neurofibromin 2. (595 aa)
H2ZSK8_LATCHTYR_PHOSPHATASE_2 domain-containing protein. (101 aa)
SHANK3SH3 and multiple ankyrin repeat domains 3. (1187 aa)
EPM2AEPM2A glucan phosphatase, laforin. (228 aa)
RB1Uncharacterized protein. (411 aa)
LEPRLeptin receptor. (1149 aa)
AREGAmphiregulin. (235 aa)
ORC3Origin recognition complex subunit 3. (720 aa)
MECP2Methyl-CpG binding protein 2. (459 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (410 aa)
LOC102356247Uncharacterized protein. (636 aa)
LOC102355265Neurofibromin 2b (merlin). (577 aa)
NF1Neurofibromin 1. (2814 aa)
CSF1RColony stimulating factor 1 receptor. (968 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (401 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (449 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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