(55 nodes) Regulation of gliogenesis network (Latimeria chalumnae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

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protein homology

Your Input:
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (401 aa)
	LOC102360711	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (299 aa)
	SLC7A5	Solute carrier family 7 member 5. (522 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	PTN	Pleiotrophin. (167 aa)
	H3B6N2_LATCH	Teneurin N-terminal domain-containing protein. (214 aa)
	H3B780_LATCH	Uncharacterized protein. (370 aa)
	NR2E1	Nuclear receptor subfamily 2 group E member 1. (477 aa)
	H3B8U3_LATCH	Serine/threonine-protein kinase TOR. (1418 aa)
	H3B938_LATCH	Teneurin N-terminal domain-containing protein. (181 aa)
	ABCC8	ATP binding cassette subfamily C member 8. (1591 aa)
	H2ZS97_LATCH	TNF_2 domain-containing protein. (143 aa)
	ASPA	Aspartoacylase. (249 aa)
	TMEM98	Transmembrane protein 98. (226 aa)
	CLCF1	Cardiotrophin like cytokine factor 1. (235 aa)
	DLX2	Distal-less homeobox 2. (278 aa)
	PTPRZ1	Protein tyrosine phosphatase receptor type Z1. (2273 aa)
	DLX1	Distal-less homeobox 1. (253 aa)
	H2ZZI1_LATCH	RING-type domain-containing protein. (424 aa)
	LOC102356030	Uncharacterized protein. (313 aa)
	H3A2T1_LATCH	Uncharacterized protein. (573 aa)
	LOC102356309	Uncharacterized protein. (314 aa)
	SERPINE2	Serpin family E member 2; Belongs to the serpin family. (403 aa)
	RB1	Uncharacterized protein. (411 aa)
	MAG	Myelin associated glycoprotein. (633 aa)
	LYN	Tyrosine-protein kinase. (515 aa)
	SYNJ1	Synaptojanin 1. (1563 aa)
	NKX6-2	NK6 homeobox 2. (278 aa)
	H3AEV1_LATCH	TNF_2 domain-containing protein. (230 aa)
	GSX2	GS homeobox 2. (279 aa)
	IL6	Uncharacterized protein. (149 aa)
	LINGO1	Leucine rich repeat and Ig domain containing 1. (617 aa)
	IL6ST	Interleukin 6 signal transducer. (922 aa)
	UFL1	UFM1 specific ligase 1. (792 aa)
	NR1D1	Nuclear receptor subfamily 1 group D member 1. (614 aa)
	NKX6-1	NK6 homeobox 1. (316 aa)
	MECP2	Methyl-CpG binding protein 2. (459 aa)
	LOC102357987	Uncharacterized protein. (2519 aa)
	GFAP	Glial fibrillary acidic protein; Belongs to the intermediate filament family. (449 aa)
	SKI	SKI proto-oncogene. (702 aa)
	H3B181_LATCH	Teneurin transmembrane protein 4. (1031 aa)
	MTOR	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family. (1009 aa)
	SOX8	SRY-box transcription factor 8. (477 aa)
	NF1	Neurofibromin 1. (2814 aa)
	NOTCH1	Notch receptor 1. (2494 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
	RNF10	Ring finger protein 10. (794 aa)
	MDK	Midkine. (141 aa)
	F2	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (618 aa)
	LOC102355265	Neurofibromin 2b (merlin). (577 aa)
	TP73	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (636 aa)
	VEGFC	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (410 aa)
	LOC102350310	GBP domain-containing protein. (339 aa)
	TNFRSF1B	TNF receptor superfamily member 1B. (465 aa)
	NF2	Neurofibromin 2. (595 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLCF1	IL6ST	ENSLACP00000001155	ENSLACP00000010218	Cardiotrophin like cytokine factor 1.	Interleukin 6 signal transducer.	0.944
CTNNB1	IL6	ENSLACP00000017209	ENSLACP00000009318	Catenin beta 1.	Uncharacterized protein.	0.454
CTNNB1	LOC102355265	ENSLACP00000017209	ENSLACP00000021520	Catenin beta 1.	Neurofibromin 2b (merlin).	0.448
CTNNB1	LOC102357987	ENSLACP00000017209	ENSLACP00000014598	Catenin beta 1.	Uncharacterized protein.	0.554
CTNNB1	NF2	ENSLACP00000017209	ENSLACP00000023580	Catenin beta 1.	Neurofibromin 2.	0.448
CTNNB1	NOTCH1	ENSLACP00000017209	ENSLACP00000020474	Catenin beta 1.	Notch receptor 1.	0.554
CTNNB1	SOX8	ENSLACP00000017209	ENSLACP00000018883	Catenin beta 1.	SRY-box transcription factor 8.	0.701
CTNNB1	TGFB1	ENSLACP00000017209	ENSLACP00000020652	Catenin beta 1.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.540
CTNNB1	TP53	ENSLACP00000017209	ENSLACP00000015915	Catenin beta 1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.609
DLX1	DLX2	ENSLACP00000002197	ENSLACP00000001538	Distal-less homeobox 1.	Distal-less homeobox 2.	0.798
DLX2	DLX1	ENSLACP00000001538	ENSLACP00000002197	Distal-less homeobox 2.	Distal-less homeobox 1.	0.798
F2	IL6	ENSLACP00000021404	ENSLACP00000009318	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Uncharacterized protein.	0.422
F2	SERPINE2	ENSLACP00000021404	ENSLACP00000005293	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Serpin family E member 2; Belongs to the serpin family.	0.981
GFAP	IL6	ENSLACP00000015185	ENSLACP00000009318	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	Uncharacterized protein.	0.692
GFAP	LINGO1	ENSLACP00000015185	ENSLACP00000009998	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	Leucine rich repeat and Ig domain containing 1.	0.424
H2ZS97_LATCH	IL6	ENSLACP00000000268	ENSLACP00000009318	TNF_2 domain-containing protein.	Uncharacterized protein.	0.470
H3AEV1_LATCH	IL6	ENSLACP00000008172	ENSLACP00000009318	TNF_2 domain-containing protein.	Uncharacterized protein.	0.470
H3B181_LATCH	H3B6N2_LATCH	ENSLACP00000015652	ENSLACP00000017553	Teneurin transmembrane protein 4.	Teneurin N-terminal domain-containing protein.	0.900
H3B181_LATCH	H3B938_LATCH	ENSLACP00000015652	ENSLACP00000018409	Teneurin transmembrane protein 4.	Teneurin N-terminal domain-containing protein.	0.900
H3B6N2_LATCH	H3B181_LATCH	ENSLACP00000017553	ENSLACP00000015652	Teneurin N-terminal domain-containing protein.	Teneurin transmembrane protein 4.	0.900