(23 nodes) Regulation of smooth muscle cell migration network (Latimeria chalumnae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	PDGFB	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (209 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (259 aa)
	SERPINE1	Serpin family E member 1; Belongs to the serpin family. (403 aa)
	GNA12	G protein subunit alpha 12. (382 aa)
	H3AC70_LATCH	LRRNT domain-containing protein. (132 aa)
	IGFBP5	Insulin like growth factor binding protein 5. (279 aa)
	LOC102348760	Uncharacterized protein. (782 aa)
	NFE2L2	Nuclear factor, erythroid 2 like 2. (590 aa)
	H3AM01_LATCH	Integrin beta; Belongs to the integrin beta chain family. (769 aa)
	PLAU	Uncharacterized protein. (469 aa)
	FOXO4	Forkhead box O4. (554 aa)
	DOCK4	Dedicator of cytokinesis 4; Belongs to the DOCK family. (1826 aa)
	SLIT2	Slit guidance ligand 2. (1372 aa)
	SORL1	Sortilin-related receptor, L(DLR class) A repeats containing. (1410 aa)
	DDR2	Discoidin domain receptor tyrosine kinase 2. (838 aa)
	MYOCD	Myocardin. (963 aa)
	PDGFRB	Platelet derived growth factor receptor beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1103 aa)
	LOC102362765	Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (537 aa)
	GNA13	G protein subunit alpha 13. (377 aa)
	NF1	Neurofibromin 1. (2814 aa)
	ABHD2	Abhydrolase domain containing 2. (431 aa)
	MDK	Midkine. (141 aa)
	VTN	Vitronectin b. (492 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADIPOQ	SERPINE1	ENSLACP00000000452	ENSLACP00000006192	Adiponectin, C1Q and collagen domain containing.	Serpin family E member 1; Belongs to the serpin family.	0.426
FOXO4	MYOCD	ENSLACP00000010904	ENSLACP00000015930	Forkhead box O4.	Myocardin.	0.430
GNA12	GNA13	ENSLACP00000006367	ENSLACP00000019021	G protein subunit alpha 12.	G protein subunit alpha 13.	0.870
GNA13	GNA12	ENSLACP00000019021	ENSLACP00000006367	G protein subunit alpha 13.	G protein subunit alpha 12.	0.870
GNA13	H3AM01_LATCH	ENSLACP00000019021	ENSLACP00000010672	G protein subunit alpha 13.	Integrin beta; Belongs to the integrin beta chain family.	0.615
H3AC70_LATCH	SLIT2	ENSLACP00000007241	ENSLACP00000012299	LRRNT domain-containing protein.	Slit guidance ligand 2.	0.900
H3AM01_LATCH	GNA13	ENSLACP00000010672	ENSLACP00000019021	Integrin beta; Belongs to the integrin beta chain family.	G protein subunit alpha 13.	0.615
H3AM01_LATCH	VTN	ENSLACP00000010672	ENSLACP00000021946	Integrin beta; Belongs to the integrin beta chain family.	Vitronectin b.	0.883
IGFBP5	VTN	ENSLACP00000008147	ENSLACP00000021946	Insulin like growth factor binding protein 5.	Vitronectin b.	0.425
MYOCD	FOXO4	ENSLACP00000015930	ENSLACP00000010904	Myocardin.	Forkhead box O4.	0.430
PDGFB	PDGFRB	ENSLACP00000002907	ENSLACP00000016550	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	Platelet derived growth factor receptor beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.999
PDGFRB	PDGFB	ENSLACP00000016550	ENSLACP00000002907	Platelet derived growth factor receptor beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.999
PLAU	SERPINE1	ENSLACP00000010869	ENSLACP00000006192	Uncharacterized protein.	Serpin family E member 1; Belongs to the serpin family.	0.991
PLAU	VTN	ENSLACP00000010869	ENSLACP00000021946	Uncharacterized protein.	Vitronectin b.	0.856
SERPINE1	ADIPOQ	ENSLACP00000006192	ENSLACP00000000452	Serpin family E member 1; Belongs to the serpin family.	Adiponectin, C1Q and collagen domain containing.	0.426
SERPINE1	PLAU	ENSLACP00000006192	ENSLACP00000010869	Serpin family E member 1; Belongs to the serpin family.	Uncharacterized protein.	0.991
SERPINE1	VTN	ENSLACP00000006192	ENSLACP00000021946	Serpin family E member 1; Belongs to the serpin family.	Vitronectin b.	0.997
SLIT2	H3AC70_LATCH	ENSLACP00000012299	ENSLACP00000007241	Slit guidance ligand 2.	LRRNT domain-containing protein.	0.900
VTN	H3AM01_LATCH	ENSLACP00000021946	ENSLACP00000010672	Vitronectin b.	Integrin beta; Belongs to the integrin beta chain family.	0.883
VTN	IGFBP5	ENSLACP00000021946	ENSLACP00000008147	Vitronectin b.	Insulin like growth factor binding protein 5.	0.425