(43 nodes) Acidic amino acid transport network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102351543	Aa_trans domain-containing protein. (253 aa)
	LOC102358762	Amino acid transporter. (538 aa)
	GIPC3	GIPC PDZ domain containing family member 3. (319 aa)
	LRRC8A	Leucine rich repeat containing 8 VRAC subunit A. (809 aa)
	GIPC1	GIPC PDZ domain containing family member 1. (333 aa)
	NF1	Neurofibromin 1. (2814 aa)
	GRM2	Glutamate metabotropic receptor 2. (870 aa)
	SLC17A8	Solute carrier family 17 member 8. (439 aa)
	LOC102345634	Amino acid transporter. (345 aa)
	LOC102362994	Solute carrier family 25 member 55b; Belongs to the mitochondrial carrier (TC 2.A.29) family. (335 aa)
	SLC6A1	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (601 aa)
	SLC25A22	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (323 aa)
	APBA1	Amyloid beta precursor protein binding family A member 1. (812 aa)
	H3AG31_LATCH	Aa_trans domain-containing protein. (462 aa)
	SLC25A12	Solute carrier family 25 member 12; Belongs to the mitochondrial carrier (TC 2.A.29) family. (677 aa)
	H3ABV2_LATCH	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (318 aa)
	SLC25A13	Solute carrier family 25 member 13; Belongs to the mitochondrial carrier (TC 2.A.29) family. (682 aa)
	EPM2A	EPM2A glucan phosphatase, laforin. (228 aa)
	SLC1A7	Amino acid transporter. (497 aa)
	NTRK2	Tyrosine-protein kinase receptor. (819 aa)
	CLN8	CLN8 transmembrane ER and ERGIC protein. (294 aa)
	SLC1A3	Amino acid transporter. (441 aa)
	SLC1A5	Amino acid transporter. (565 aa)
	H2ZSK8_LATCH	TYR_PHOSPHATASE_2 domain-containing protein. (101 aa)
	SLC17A6	Solute carrier family 17 member 6. (391 aa)
	ARL6IP5	PRA1 family protein. (196 aa)
	H3B1Q1_LATCH	Amino acid transporter. (383 aa)
	SLC1A4	Amino acid transporter. (188 aa)
	SLC32A1	Solute carrier family 32 member 1. (520 aa)
	GIPC2	GIPC PDZ domain containing family member 2. (327 aa)
	SLC1A6	Amino acid transporter. (547 aa)
	LRRC8E	Leucine rich repeat containing 8 VRAC subunit E. (793 aa)
	SLC17A7	MFS domain-containing protein. (560 aa)
	LRRC8D	Leucine rich repeat containing 8 VRAC subunit D. (848 aa)
	SLC1A2	Amino acid transporter. (566 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (465 aa)
	LRRC8C	Leucine rich repeat containing 8 VRAC subunit C. (805 aa)
	H3AQM3_LATCH	Aa_trans domain-containing protein. (401 aa)
	SLC3A1	Solute carrier family 3 member 1. (681 aa)
	H3AM63_LATCH	Aa_trans domain-containing protein. (408 aa)
	SLC7A11	Solute carrier family 7 member 11. (501 aa)
	CCDC77	Coiled-coil domain containing 77. (465 aa)
	SLC1A1	Amino acid transporter. (523 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARL6IP5	SLC1A1	ENSLACP00000015834	ENSLACP00000008804	PRA1 family protein.	Amino acid transporter.	0.625
EPM2A	H2ZSK8_LATCH	ENSLACP00000004885	ENSLACP00000000379	EPM2A glucan phosphatase, laforin.	TYR_PHOSPHATASE_2 domain-containing protein.	0.921
GIPC3	SLC6A1	ENSLACP00000017169	ENSLACP00000021638	GIPC PDZ domain containing family member 3.	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.	0.515
H2ZSK8_LATCH	EPM2A	ENSLACP00000000379	ENSLACP00000004885	TYR_PHOSPHATASE_2 domain-containing protein.	EPM2A glucan phosphatase, laforin.	0.921
H3B1Q1_LATCH	SLC1A4	ENSLACP00000015822	ENSLACP00000015774	Amino acid transporter.	Amino acid transporter.	0.951
H3B1Q1_LATCH	SLC3A1	ENSLACP00000015822	ENSLACP00000011899	Amino acid transporter.	Solute carrier family 3 member 1.	0.635
LOC102345634	SLC1A4	ENSLACP00000020079	ENSLACP00000015774	Amino acid transporter.	Amino acid transporter.	0.949
LOC102345634	SLC3A1	ENSLACP00000020079	ENSLACP00000011899	Amino acid transporter.	Solute carrier family 3 member 1.	0.649
LOC102358762	SLC3A1	ENSLACP00000016559	ENSLACP00000011899	Amino acid transporter.	Solute carrier family 3 member 1.	0.747
LRRC8A	LRRC8C	ENSLACP00000017933	ENSLACP00000012592	Leucine rich repeat containing 8 VRAC subunit A.	Leucine rich repeat containing 8 VRAC subunit C.	0.993
LRRC8A	LRRC8D	ENSLACP00000017933	ENSLACP00000013813	Leucine rich repeat containing 8 VRAC subunit A.	Leucine rich repeat containing 8 VRAC subunit D.	0.946
LRRC8A	LRRC8E	ENSLACP00000017933	ENSLACP00000014592	Leucine rich repeat containing 8 VRAC subunit A.	Leucine rich repeat containing 8 VRAC subunit E.	0.978
LRRC8C	LRRC8A	ENSLACP00000012592	ENSLACP00000017933	Leucine rich repeat containing 8 VRAC subunit C.	Leucine rich repeat containing 8 VRAC subunit A.	0.993
LRRC8C	LRRC8D	ENSLACP00000012592	ENSLACP00000013813	Leucine rich repeat containing 8 VRAC subunit C.	Leucine rich repeat containing 8 VRAC subunit D.	0.618
LRRC8C	LRRC8E	ENSLACP00000012592	ENSLACP00000014592	Leucine rich repeat containing 8 VRAC subunit C.	Leucine rich repeat containing 8 VRAC subunit E.	0.499
LRRC8D	LRRC8A	ENSLACP00000013813	ENSLACP00000017933	Leucine rich repeat containing 8 VRAC subunit D.	Leucine rich repeat containing 8 VRAC subunit A.	0.946
LRRC8D	LRRC8C	ENSLACP00000013813	ENSLACP00000012592	Leucine rich repeat containing 8 VRAC subunit D.	Leucine rich repeat containing 8 VRAC subunit C.	0.618
LRRC8D	LRRC8E	ENSLACP00000013813	ENSLACP00000014592	Leucine rich repeat containing 8 VRAC subunit D.	Leucine rich repeat containing 8 VRAC subunit E.	0.604
LRRC8E	LRRC8A	ENSLACP00000014592	ENSLACP00000017933	Leucine rich repeat containing 8 VRAC subunit E.	Leucine rich repeat containing 8 VRAC subunit A.	0.978
LRRC8E	LRRC8C	ENSLACP00000014592	ENSLACP00000012592	Leucine rich repeat containing 8 VRAC subunit E.	Leucine rich repeat containing 8 VRAC subunit C.	0.499