(101 nodes) Organic hydroxy compound transport network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	APOB	Apolipoprotein B. (4644 aa)
	SLC2A13	Solute carrier family 2 member 13; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (612 aa)
	M3XL67_LATCH	Uncharacterized protein. (157 aa)
	STRA6	Stimulated by retinoic acid 6. (664 aa)
	VPS4B	Vacuolar protein sorting 4 homolog B; Belongs to the AAA ATPase family. (448 aa)
	LOC102363648	Retinol binding protein 4, like; Belongs to the calycin superfamily. Lipocalin family. (202 aa)
	LOC102354720	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (291 aa)
	H2ZV76_LATCH	Uncharacterized protein. (145 aa)
	LOC102352186	Vitellogenin domain-containing protein. (463 aa)
	STARD4	StAR related lipid transfer domain containing 4. (216 aa)
	OSBPL6	Oxysterol-binding protein; Belongs to the OSBP family. (384 aa)
	OSBPL9	Oxysterol-binding protein; Belongs to the OSBP family. (685 aa)
	OSBPL10	Oxysterol-binding protein; Belongs to the OSBP family. (567 aa)
	SLC6A3	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (624 aa)
	MTTP	Microsomal triglyceride transfer protein. (893 aa)
	OSBPL8	Oxysterol-binding protein; Belongs to the OSBP family. (855 aa)
	CFTR	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1491 aa)
	SLC29A4	Solute carrier family 29 member 4. (527 aa)
	GRAMD1A	GRAM domain containing 1A. (864 aa)
	ABCG1	ATP binding cassette subfamily G member 1. (649 aa)
	NPC2	NPC intracellular cholesterol transporter 2. (148 aa)
	P2RX1	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (403 aa)
	DRD2	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (450 aa)
	LRP6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1615 aa)
	ABCG4	ATP binding cassette subfamily G member 4. (653 aa)
	PINK1	PTEN induced kinase 1. (467 aa)
	SLC16A1	Solute carrier family 16 member 1. (504 aa)
	OSBPL7	Oxysterol binding protein like 7. (919 aa)
	LOC102350608	Oxysterol-binding protein; Belongs to the OSBP family. (789 aa)
	ARV1	ARV1 homolog, fatty acid homeostasis modulator. (232 aa)
	STARD3	StAR related lipid transfer domain containing 3. (445 aa)
	ABCG5	ATP binding cassette subfamily G member 5. (438 aa)
	OSBPL5	Oxysterol-binding protein; Belongs to the OSBP family. (884 aa)
	H3B6R7_LATCH	Ion_trans domain-containing protein. (303 aa)
	LOC102360404	STRA6-like. (603 aa)
	CEL	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (552 aa)
	ABCG8	ATP binding cassette subfamily G member 8. (677 aa)
	APOA4	Apolipoprotein A4. (367 aa)
	SLC5A12	Solute carrier family 5 member 12; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (625 aa)
	OSBPL1A	Oxysterol-binding protein; Belongs to the OSBP family. (967 aa)
	LOC102365332	Apolipoprotein Ea. (278 aa)
	SLC6A2	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (639 aa)
	SLC6A4	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (660 aa)
	STARD5	StAR related lipid transfer domain containing 5. (213 aa)
	PODNL1	Podocan like 1. (599 aa)
	SLC16A3	Solute carrier family 16 member 3. (479 aa)
	SLCO1A2	Solute carrier organic anion transporter family member. (711 aa)
	H3B0K2_LATCH	START domain-containing protein. (279 aa)
	LOC102350159	Vitellogenin domain-containing protein. (663 aa)
	SLC18A2	Solute carrier family 18 member A2. (523 aa)
	FGF19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
	LOC102361614	Solute carrier organic anion transporter family member. (717 aa)
	SPG11	SPG11 vesicle trafficking associated, spatacsin. (2438 aa)
	LDLRAP1	Low density lipoprotein receptor adaptor protein 1b. (316 aa)
	NR0B2	Nuclear receptor subfamily 0 group B member 2. (260 aa)
	SYK	Tyrosine-protein kinase. (616 aa)
	MECP2	Methyl-CpG binding protein 2. (459 aa)
	EMB	Embigin. (259 aa)
	OSBPL11	Oxysterol-binding protein; Belongs to the OSBP family. (690 aa)
	RELCH	RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1037 aa)
	LIPC	Lipase C, hepatic type. (503 aa)
	SLC10A3	Solute carrier family 10 member 3. (406 aa)
	SYT7	Synaptotagmin 7. (286 aa)
	H3AMG4_LATCH	Uncharacterized protein. (141 aa)
	STAR	Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (285 aa)
	RALBP1	RalA binding protein 1. (659 aa)
	VPS4A	Vacuolar protein sorting 4 homolog A; Belongs to the AAA ATPase family. (437 aa)
	KCNQ1	Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (351 aa)
	LIMA1	LIM domain and actin binding 1. (545 aa)
	PARK7	Parkinsonism associated deglycase. (217 aa)
	SLC10A2	Solute carrier family 10 member 2. (345 aa)
	H3AIJ4_LATCH	Uncharacterized protein. (1107 aa)
	OSBPL2	Oxysterol-binding protein; Belongs to the OSBP family. (475 aa)
	H3AHJ4_LATCH	Ion_trans domain-containing protein; Belongs to the potassium channel family. (298 aa)
	LOC102367330	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (616 aa)
	SLC10A1	Solute carrier family 10 member 1. (365 aa)
	H3AEK5_LATCH	Aquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (268 aa)
	SLC16A8	Solute carrier family 16 member 8. (513 aa)
	AQP11	Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. (271 aa)
	LOC102364982	Solute carrier family 22 member 2. (562 aa)
	SLC16A7	Solute carrier family 16 member 7. (484 aa)
	H3AB79_LATCH	Uncharacterized protein. (135 aa)
	SERAC1	Serine active site containing 1. (657 aa)
	PODN	Podocan. (621 aa)
	LOC102366871	Uncharacterized protein. (310 aa)
	GRAMD1C	GRAM domain containing 1C. (564 aa)
	ABCD3	ATP binding cassette subfamily D member 3. (684 aa)
	OSBPL3	Oxysterol-binding protein; Belongs to the OSBP family. (855 aa)
	OSBP	Oxysterol-binding protein; Belongs to the OSBP family. (715 aa)
	VIP	Vasoactive intestinal peptide. (205 aa)
	APOM	Apolipoprotein M. (194 aa)
	AQP3	Aquaporin 3 (Gill blood group); Belongs to the MIP/aquaporin (TC 1.A.8) family. (258 aa)
	STARD3NL	STARD3 N-terminal like. (234 aa)
	PLTP	Phospholipid transfer protein. (495 aa)
	NPC1L1	NPC1 like intracellular cholesterol transporter 1. (1104 aa)
	NPC1	NPC intracellular cholesterol transporter 1. (1284 aa)
	LCAT	Lecithin-cholesterol acyltransferase. (428 aa)
	GRAMD1B	GRAM domain containing 1Bb. (692 aa)
	AQP9	Aquaporin 9; Belongs to the MIP/aquaporin (TC 1.A.8) family. (290 aa)
	SLC22A3	Solute carrier family 22 member 3. (365 aa)
	SCARB1	Scavenger receptor class B member 1; Belongs to the CD36 family. (521 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCG1	ABCG5	ENSLACP00000004101	ENSLACP00000017950	ATP binding cassette subfamily G member 1.	ATP binding cassette subfamily G member 5.	0.848
ABCG1	PLTP	ENSLACP00000004101	ENSLACP00000021320	ATP binding cassette subfamily G member 1.	Phospholipid transfer protein.	0.418
ABCG4	ABCG5	ENSLACP00000020332	ENSLACP00000017950	ATP binding cassette subfamily G member 4.	ATP binding cassette subfamily G member 5.	0.836
ABCG4	PLTP	ENSLACP00000020332	ENSLACP00000021320	ATP binding cassette subfamily G member 4.	Phospholipid transfer protein.	0.418
ABCG5	ABCG1	ENSLACP00000017950	ENSLACP00000004101	ATP binding cassette subfamily G member 5.	ATP binding cassette subfamily G member 1.	0.848
ABCG5	ABCG4	ENSLACP00000017950	ENSLACP00000020332	ATP binding cassette subfamily G member 5.	ATP binding cassette subfamily G member 4.	0.836
ABCG5	ABCG8	ENSLACP00000017950	ENSLACP00000016915	ATP binding cassette subfamily G member 5.	ATP binding cassette subfamily G member 8.	0.999
ABCG5	APOA4	ENSLACP00000017950	ENSLACP00000016757	ATP binding cassette subfamily G member 5.	Apolipoprotein A4.	0.415
ABCG5	APOB	ENSLACP00000017950	ENSLACP00000022987	ATP binding cassette subfamily G member 5.	Apolipoprotein B.	0.512
ABCG5	H3AIJ4_LATCH	ENSLACP00000017950	ENSLACP00000009465	ATP binding cassette subfamily G member 5.	Uncharacterized protein.	0.486
ABCG5	MTTP	ENSLACP00000017950	ENSLACP00000002839	ATP binding cassette subfamily G member 5.	Microsomal triglyceride transfer protein.	0.446
ABCG5	NPC1L1	ENSLACP00000017950	ENSLACP00000021855	ATP binding cassette subfamily G member 5.	NPC1 like intracellular cholesterol transporter 1.	0.683
ABCG5	NR0B2	ENSLACP00000017950	ENSLACP00000013086	ATP binding cassette subfamily G member 5.	Nuclear receptor subfamily 0 group B member 2.	0.505
ABCG5	SCARB1	ENSLACP00000017950	ENSLACP00000023060	ATP binding cassette subfamily G member 5.	Scavenger receptor class B member 1; Belongs to the CD36 family.	0.420
ABCG5	SLC10A1	ENSLACP00000017950	ENSLACP00000008119	ATP binding cassette subfamily G member 5.	Solute carrier family 10 member 1.	0.480
ABCG8	ABCG5	ENSLACP00000016915	ENSLACP00000017950	ATP binding cassette subfamily G member 8.	ATP binding cassette subfamily G member 5.	0.999
ABCG8	APOB	ENSLACP00000016915	ENSLACP00000022987	ATP binding cassette subfamily G member 8.	Apolipoprotein B.	0.420
ABCG8	H3AIJ4_LATCH	ENSLACP00000016915	ENSLACP00000009465	ATP binding cassette subfamily G member 8.	Uncharacterized protein.	0.454
ABCG8	NPC1L1	ENSLACP00000016915	ENSLACP00000021855	ATP binding cassette subfamily G member 8.	NPC1 like intracellular cholesterol transporter 1.	0.647
ABCG8	NR0B2	ENSLACP00000016915	ENSLACP00000013086	ATP binding cassette subfamily G member 8.	Nuclear receptor subfamily 0 group B member 2.	0.400